Ask about this productRelated genes to: SELS antibody
- Gene:
- SELENOS NIH gene
- Name:
- selenoprotein S
- Previous symbol:
- VIMP
- Synonyms:
- SELS, MGC2553, SBBI8, AD-015, SEPS1
- Chromosome:
- 15q26.3
- Locus Type:
- gene with protein product
- Date approved:
- 2012-05-23
- Date modifiied:
- 2016-09-21
Related products to: SELS antibody
Related articles to: SELS antibody
- Developing synthetic methods that allow controllable homologation to quickly access new chemical space is vital yet remains challenging for studying biological pathways. Utilizing underexplored elements as biological probes offers promising platforms to reveal uncharted aspects of G-protein-coupled receptor (GPCR) pharmacology. Here we report the development of an expeditious, sustainable platform for the scalable conversion of chloro-imidoylsulfonylureas, to provide one-pot access to synthetically versatile chiral, pro-chiral and achiral selenosulfonyl homologated compounds bearing the cannabinoid receptor-1 (CBR) recognition motifs. The synthetic route was designed using NaSeSO, a benign selenium source under aqueous conditions to enable the target-oriented synthesis of novel seleno-cannabinoid agents labeled as SelenoCanns. This Bunte-reaction-inspired seleno-homologation opens the door for on-demand synthesis of bioactive organoselenium drug-like molecules, covalent-drug conjugates, click handles, and seleno-fluorescent probes, thus opening a vast space of previously inaccessible molecules for expanded structure-function studies on the CBR. Of the new chemotypes discovered and synthesized, many compounds showed nanomolar to sub-nanomolar binding affinity for the CB1 receptor. - Source: PubMed
Publication date: 2026/04/28
Iyer Malliga RBhattacharjee PinakiDutta SubhradeepLobe Maloba M MVolesky Paul DGodlewski GrzegorzPuhl Henry LHassan Sergio A - Herein, we report a sustainable, metal-free tandem mechanochemical strategy for the construction and C-H chalcogenocyanation of indolizines from pyridine-2-carboxaldehydes and α,β-unsaturated compounds. The method involves DABCO-catalyzed in situ formation of the Baylis-Hillman adduct followed by cyclization, delivering 2-functionalized indolizines within 30 min under solid-phase mixer-milling conditions, with yields of up to 81%. Several of these products were further subjected to mechanochemical thio- and seleno-cyanation. Notably, a combination of commercially available NaSCN/KSeCN and NCS first generates electrophilic chalcogenocyanating agents that afford the unprecedented 1-chalcogenocyanated-2-formyl-indolizine scaffold in just 15 min with up to 94% yields, in a work-up-free process. Interestingly, silica-assisted solid-phase mechanochemistry enables tandem conversion of the starting pyridine-2-carboxaldehydes and enones directly into 1,2-difunctionalized indolizines, with practically no drop in overall yields (best yield 75%). Furthermore, the dual-functional handles allow diverse post-functionalizations, including the conversion of -SCN to -SCF and sulfenyl tetrazoles, and -CHO to indolizino-benzazoles, all via mixer-milling. The scalability of the tandem mechanosynthesis of 1,2-difunctionalized indolizines was established using selected examples. The time-efficient and step-economic solid-phase tandem mechanochemical method exhibits strong sustainability metrics, including low process mass intensity (PMI 9.1 g g), low E-factors (4.1), good atom economy (65% AE), and a high EcoScale score (∼70). - Source: PubMed
Saha SoumikB ShravyaMulgaonkar Truptesh TBhattacharya SauravChatterjee AmritaBanerjee Mainak - Broiler chickens are fast-growing and highly susceptible to dietary selenium (Se) deficiency, with environmental stressors like heat stress further intensifying their vulnerability. - Source: PubMed
Publication date: 2026/04/21
Yang Jia-ChengSun HuaHuang Rong-HuiZhao LingLei Xin-GenSun Lv-Hui - Native chemical ligation (NCL) enables the synthesis of complex peptides and proteins. Prior work in NCL at phenylalanine (Phe) employed β-mercapto or β-seleno (alkyl) derivatives. Herein, we describe an alternative approach to NCL at Phe, via an aryl thiol on the novel Phe surrogate ortho-mercaptophenylalanine (2-mercaptophenylalanine). Commercially available Boc-2-iodo-phenylalanine was incorporated at the N-terminus of the peptide. A solid-phase copper mediated cross-coupling reaction with thioacetic acid was conducted on fully synthesized peptides with an N-terminal Boc-2-I-Phe to introduce, after TFA cleavage and deprotection, a nucleophilic aryl thiolate in the resultant N-terminal residue 2-mercaptophenylalanine (pK = 5.1, substantially lower than alkyl thiols). Alternatively, 2-mercaptophenylalanine could be incorporated via the short synthesis of Boc-2-(S-tert-butyl)mercaptophenylalanine and coupling to peptide on resin. Peptides containing 2-mercaptophenylalanine rapidly underwent NCL reactions with peptides containing C-terminal thioesters. NCL reactions with the thioesters of Gly, Ala, Leu, and Phe were complete in 5 min1 h at room temperature at 0.52 mM peptide concentrations. Reactions with Val and Pro thioesters also proceeded in high yield, in 6 h and 12 h, respectively. NCL reactions with 2-mercaptophenylalanine also proceeded efficiently at pH 5. The peptide ligation product was desulfurized using nickel boride to generate phenylalanine. These results, using commercially available reagents and the possibility of amino acid synthesis on the solid phase which eliminates the requirement for solution-phase amino acid synthesis, represent a practical approach to NCL at phenylalanine. - Source: PubMed
Forbes Christina RLudwig Brice AYap Glenn P AZondlo Neal J - - Source: PubMed
Publication date: 2026/04/22
Li QinhuiWu YikunXu YuangaoShi HuaXu JinhongXu Shuxiong