Ask about this productRelated genes to: ZXDC antibody
- Gene:
- ZXDC NIH gene
- Name:
- ZXD family zinc finger C
- Previous symbol:
- -
- Synonyms:
- MGC11349, FLJ13861
- Chromosome:
- 3q21.3
- Locus Type:
- gene with protein product
- Date approved:
- 2005-05-10
- Date modifiied:
- 2015-08-24
Related products to: ZXDC antibody
Related articles to: ZXDC antibody
- Tire antioxidant degradation product N-(1,3-dimethylbutyl)-N'-phenyl-p-phenylenediamine quinone (6PPD-Q), an emerging environmental pollutant, has been suggested to influence tumor-related biological processes; however, its role in HCC remains unclear. Here, we evaluated the effects of 6PPD-Q on HCC cells by assessing transcriptomic profiles, proliferation, migration, and erastin-induced/Ferrostatin-1-inhibited ferroptosis, and interrogated the regulatory role of zinc finger X-linked duplicated family zinc finger C (ZXDC) using knockdown and overexpression approaches. 6PPD-Q markedly promoted HCC cell proliferation and migration while reducing sensitivity to erastin-triggered ferroptosis. Mechanistically, ZXDC expression was upregulated by 6PPD-Q in HCC cells and served as a prognostic indicator. Moreover, ZXDC acted as a critical mediator of these pro-tumorigenic and anti-ferroptotic effects: ZXDC knockdown attenuated 6PPD-Q-induced proliferation and migration while promoting ferroptosis, whereas ZXDC overexpression further suppressed ferroptosis. In parallel, multi-algorithm immune infiltration analyses showed that the 6PPD-Q-related gene risk score was significantly associated with multiple immune populations, with macrophage M0 cells showing a significant positive correlation with the risk score (R = 0.30, p < 0.001). Collectively, these findings identify a 6PPD-Q/ZXDC axis that links environmental exposure to HCC malignant progression and ferroptosis resistance, suggesting ZXDC as a potential biomarker and intervention target for HCC prevention and therapy. - Source: PubMed
Publication date: 2026/02/03
Yao QihangCao BinbinGuo ZihanGong Chenglin - X chromosome centromeric drive may explain the prevalence of polycystic ovary syndrome and contribute to oocyte aneuploidy, menopause, and other conditions. The mammalian X chromosome may be vulnerable to meiotic drive because of X inactivation in the female germline. The human X pericentromeric region contains genes potentially involved in meiotic mechanisms, including multiple SPIN1 and ZXDC paralogs. This is consistent with a multigenic drive system comprising differential modification of the active and inactive X chromosome centromeres in female primordial germ cells and preferential segregation of the previously inactivated X chromosome centromere to the polar body at meiosis I. The drive mechanism may explain differences in X chromosome regulation in the female germlines of the human and mouse and, based on the functions encoded by the genes in the region, the transmission of X pericentromeric genetic or epigenetic variants to progeny could contribute to preeclampsia, autism, and differences in sexual differentiation. - Source: PubMed
Publication date: 2024/07/29
Moore Tom - Some patients diagnosed with benign IgA nephropathy (IgAN) develop a progressive clinical course, not predictable by known clinical or histopathological parameters. To assess if gene expression can differentiate between progressors and non-progressors with assumed benign IgAN, we tested microdissected glomeruli from archival kidney biopsy sections from adult patients with stable clinical remission (21 non-progressors) or from 15 patients that had undergone clinical progression within a 25-year time frame. Based on 1 240 differentially expressed genes from patients with suitable sequencing results, we identified eight IgAN progressor and nine non-progressor genes using a two-component classifier. These genes, including APOL5 and ZXDC, predicted disease progression with 88% accuracy, 75% sensitivity and 100% specificity on average 21.6 years before progressive disease was clinically documented. APOL lipoproteins are associated with inflammation, autophagy and kidney disease while ZXDC is a zinc-finger transcription factor modulating adaptive immunity. Ten genes from our transcriptomics data overlapped with an external genome wide association study dataset, although the gene set enrichment test was not statistically significant. We also identified 45 drug targets in the DrugBank database, including angiotensinogen, a target of sparsentan (dual antagonist of the endothelin type A receptor and the angiotensin II type 1 receptor) currently investigated for IgAN treatment. Two validation cohorts were used for substantiating key results, one by immunohistochemistry and the other by nCounter technology. Thus, glomerular mRNA sequencing from diagnostic kidney biopsies from patients with assumed benign IgAN can differentiate between future progressors and non-progressors at the time of diagnosis. - Source: PubMed
Publication date: 2023/12/26
Rivedal MariellMikkelsen HåvardMarti Hans-PeterLiu LiliKiryluk KrzysztofKnoop ThomasBjørneklett RuneHaaskjold Yngvar LundeFurriol JessicaLeh SabinePaunas FlaviaBábíčková JankaScherer AndreasSerre CamilleEikrem OysteinStrauss Philipp - Metastasis in cervical cancer (CC) has a significant negative impact on patient survival, highlighting the urgent need for investigation in this area. In this study, we identified significant overexpression of zinc finger, X-linked, duplicated family member C () in CC tissue with metastasis, which correlates with poor outcomes for CC patients. We observed that overexpression of promotes, while silencing of inhibits the metastasis of CC cells both and . Additionally, our research demonstrated that activated / signaling pathway, leading to enhanced cytoskeleton remodeling in CC cells. Besides, we found that plays an essential role in the activation of on the / signaling pathway by stabilizing mRNA. These findings reveal a mechanism whereby promotes the cervical cancer metastasis by targeting // pathway. - Source: PubMed
Publication date: 2023/07/20
Mao YifangJiang XingyuGuo PengOuyang YingChen XiangfuXia MengWu LixinTang ZihaoLiang TianyiLi YueHe Mian - Age and sex have a profound effect on cytosine methylation levels in humans and many other species. Here we analyzed DNA methylation profiles of 2400 tissues derived from 37 primate species including 11 haplorhine species (baboons, marmosets, vervets, rhesus macaque, chimpanzees, gorillas, orangutan, humans) and 26 strepsirrhine species (suborders Lemuriformes and Lorisiformes). From these we present here, pan-primate epigenetic clocks which are highly accurate for all primates including humans (age correlation R = 0.98). We also carried out in-depth analysis of baboon DNA methylation profiles and generated five epigenetic clocks for baboons (Olive-yellow baboon hybrid), one of which, the pan-tissue epigenetic clock, was trained on seven tissue types (fetal cerebral cortex, adult cerebral cortex, cerebellum, adipose, heart, liver, and skeletal muscle) with ages ranging from late fetal life to 22.8 years of age. Using the primate data, we characterize the effect of age and sex on individual cytosines in highly conserved regions. We identify 11 sex-related CpGs on autosomes near genes (POU3F2, CDYL, MYCL, FBXL4, ZC3H10, ZXDC, RRAS, FAM217A, RBM39, GRIA2, UHRF2). Low overlap can be observed between age- and sex-related CpGs. Overall, this study advances our understanding of conserved age- and sex-related epigenetic changes in primates, and provides biomarkers of aging for all primates. - Source: PubMed
Publication date: 2023/07/26
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