Ask about this productRelated genes to: ZMYND10 antibody
- Gene:
- ZMYND10 NIH gene
- Name:
- zinc finger MYND-type containing 10
- Previous symbol:
- -
- Synonyms:
- BLU, CILD22, DNAAF7
- Chromosome:
- 3p21.31
- Locus Type:
- gene with protein product
- Date approved:
- 2003-05-01
- Date modifiied:
- 2018-05-31
Related products to: ZMYND10 antibody
Related articles to: ZMYND10 antibody
- Deoxynivalenol (DON) is a common mycotoxin linked to ovarian oxidative stress, toxicity, and reduced reproductive performance. Fermented Chinese chive is known for its antioxidant properties and potential reproductive benefits, but their individual and combined effects on ovarian function remain unclear in post-pubertal mice. In this study, a 21-day oral gavage model in female Kunming mice was used to evaluate the effects of DON (2 mg/kg/day), fermented Chinese chive extract (LEEK; 0.2 mL/day), and their combined exposure (LKDON) on ovarian physiology, oocyte quality, and ovarian transcriptomic responses. The results showed that DON exposure significantly reduced the zygote cleavage rate, increased intracellular reactive oxygen species levels, and disrupted oocyte mitochondrial membrane potential. While histological examination revealed disturbed follicular architecture. Transcriptomic hub gene analysis showed that DON exposure down-regulate the key associated with innate immune responses and motile cilia/axonemal structure, including , , , , and . In contrast, LEEK alone was associated with immunomodulatory upregulated genes, including , , and . Interestingly, LKDON and DON comparison revealed upregulation of a motile cilia/axoneme gene network (, , , , , and ), rather than a global reversal of DON-induced changes. Overall, finding suggest that DON disrupts ovarian immune and structural pathways, while fermented Chinese chive provides partial protection by modulating specific biological processes. Further studies are needed to confirm the underlying mechanisms. - Source: PubMed
Publication date: 2026/04/01
Zou HongQin Chun-YanSuthar Teerath KumarXie YupengAbednicco Koroloso PhomaneWang Chun-FengKim Min KyuZhang Shu-MinSun Wu-Sheng - Prenatal stress and environmental metal mixtures impact neurobehavioral development, yet their interplay and potential mechanisms via placental epigenetics remain unclear. We investigated whether prenatal metal mixtures moderate the epigenetic pathway linking maternal stress at delivery (corticotropin-releasing hormone, CRH) to infant neurobehavioral development. - Source: PubMed
Publication date: 2026/04/28
Du SisiYan JiewenChen LihuaFu MaliYe RanranWang LuWu XiaoxiaWen PingTu XinzhiTian Fu-Ying - This study investigated the impact of benzo[a]pyrene (BaP) exposure on male reproductive health, revealing a dose-dependent decline in sperm count, density, and serum testosterone levels. BaP exposure significantly impaired sperm motility, as evidenced by reduced kinematic parameters (VSL, VCL, VAP, LIN, STR, WOB). Molecular analysis demonstrated that BaP downregulated the expression of key genes, including ZMYND10 and its associated motility protein DNALI1, and the spermiogenesis regulator ZMYND15 along with its downstream targets (DPY19L2, AKAP4, AKAP3, SPEM1, PRM1, CATSPER3). These alterations in gene expression are linked to structural and functional deficits in sperm, such as abnormal morphology (coiled tails, folded heads) and impaired flagellar development. Our research infers that Bap diminishes sperm quality in male rats and induces reproductive harm by downregulating ZMYND15 and ZMYND10, hence influencing the expression of their associated genes. This study elucidates a novel mechanism for BaP-induced impairment of sperm quality. - Source: PubMed
Publication date: 2026/03/17
Zhao XinruiDong XiuxiaFu PengjuanChen YongkangLiu NaWang BoheFeng XiaojuanLi Xiangli - Multiciliated cells (MCCs) play a crucial role in various physiological processes, including cerebrospinal fluid flow, mucus clearance, and reproductive transport, by coordinating ciliary movement. Their differentiation is regulated by the Notch signaling pathway, along with its downstream targets, Gemc1 and Mcidas transcription factors. This study focuses on Zmynd10, a dynein axonemal assembly factor, to investigate its molecular mechanisms that regulate polycilia differentiation. By constructing a model of Zmynd10-specific knockdown in mouse ependymal cells (mEPCs), we found that Zmynd10 knockdown resulted in a decrease in ciliary density and significantly downregulated the mRNA and protein expression of E2f4 and Deup1. Further experiments demonstrated that E2f4 knockdown inhibited Deup1 expression and reduced cilia numbers, while Zmynd10 regulated the E2f4-Deup1 axis by activating the E2f4 promoter. This study reveals for the first time that Zmynd10 drives centriole amplification through the transcriptional regulation of the E2f4-Deup1 pathway, providing new insights into the molecular mechanisms underlying multicilia differentiation. - Source: PubMed
Publication date: 2025/12/18
Liu ZhimingWu QinZhou ZhenhaiTan WenZhong JunlongFan ShuaiCao KaiHuang Lu - Oncolytic viruses (OVs) represent a promising nanomedicine strategy for cancer therapy, yet their clinical application-particularly oral administration-remains challenging due to degradation by digestive enzymes and neutralization by antibodies in the gastrointestinal tract. To address this, we developed a biomineralized cancer membrane-coated oncolytic adenovirus (CaCO@CM-OA) with enhanced resistance to enzymatic and immune clearance, significantly improving tumor-targeting efficiency. In colorectal and pancreatic cancer models, this engineered virus induced potent anti-tumor effects G2/M phase arrest, mediated by p53 phosphorylation and p21 upregulation, while suppressing epithelial-mesenchymal transition (EMT) through downregulation of N-cadherin, vimentin, and α-SMA. Furthermore, the virus triggered multimodal regulated cell death, including mitochondrial apoptosis, autophagy, and necroptosis, accompanied by immunogenic cell death (ICD) markers such as ATP release, calreticulin exposure, and HMGB1 translocation, indicating robust immune activation. Transcriptomic analysis further revealed downregulation of pro-survival genes (e.g., RHBDD2) and modulation of proliferation-related (e.g., ZMYND10, CDC27, ST7) and endocytosis-related (SNX11) genes, elucidating its multifaceted mechanism. This study highlights the potential of biomineralized OVs to overcome oral delivery barriers and enhance therapeutic efficacy in gastrointestinal cancers. By inducing synergistic cell death and immune activation, this strategy provides a foundation for clinical translation and identifies novel molecular targets for future investigation. Our findings underscore the feasibility of engineered oral OV formulations to improve treatment outcomes in intestinal malignancies. - Source: PubMed
Publication date: 2025/11/21
Hu ZujianSun YiningYu ShenleiZheng FanYan ZhuoLu NingYe LuyiYuan ShanshanZhu YutingDeng JunjieWang JilongBai Yongheng