Ask about this productRelated genes to: ZFYVE16 antibody
- Gene:
- ZFYVE16 NIH gene
- Name:
- zinc finger FYVE-type containing 16
- Previous symbol:
- -
- Synonyms:
- KIAA0305, PPP1R69
- Chromosome:
- 5q14.1
- Locus Type:
- gene with protein product
- Date approved:
- 2003-04-01
- Date modifiied:
- 2016-02-15
Related products to: ZFYVE16 antibody
Related articles to: ZFYVE16 antibody
- LAMP1 and LAMP2A (an isoform of LAMP2) are abundant proteins of late endosomal/lysosomal compartments that are often used interchangeably to label what is assumed to be the same organelle population, potentially obscuring distinct physiological roles. Here, we characterised the axonal transport dynamics of LAMP1- and LAMP2A-positive compartments in human induced pluripotent stem cell (hiPSC)-derived cortical neurons. We found that LAMP1-positive organelles move slower in the retrograde direction, pause more frequently, and display a broader anterograde velocity distribution than LAMP2A-positive vesicles, indicating distinct trafficking behaviours. Co-transport analysis revealed that ∼65% of motile LAMP1-positive organelles carry LAMP2A, and vice versa, with higher co-transport in the retrograde direction. To explore molecular differences underlying these behaviours, we performed proximity labelling using full-length LAMP1 or LAMP2A fused to the light-activated biotin ligase LOV-Turbo. This approach revealed largely overlapping interactomes, with LAMP2A-associated proteins forming a subset of the LAMP1 interactome and showing an enrichment for synaptic vesicle-related proteins. We further validated ZFYVE16 as a novel interactor of both compartments. Together, our findings indicate that LAMP1- and LAMP2A-positive organelles share overlapping molecular identities but represent functionally distinct axonal populations with divergent transport dynamics. - Source: PubMed
Publication date: 2026/02/16
Abouward ReemAbdelhafid Alya MasoudWilkins Oscar GLee Song-YiIbrahim FairouzSkehel MarkTing AliceBirsa NicolUle JernejSchiavo Giampietro - Although DHFR gene amplification has long been known as a major mechanism for methotrexate (MTX) resistance in cancer, the early changes and detailed development of the resistance are not yet fully understood. - Source: PubMed
Publication date: 2024/04/09
Meng Xiang-NingMa Jin-FaLiu Yang-HeLi Si-QingWang XuZhu JingCai Meng-DiZhang Hui-ShuSong TiantianXing ShukaiHou Li-QingGuo HuanCui Xiao-BoHan JiangLiu PengJi Guo-HuaSun Wen-JingYu Jing-CuiFu Song-Bin - The Scale for Assessment and Rating of Ataxia (SARA) is widely used in different types of ataxias and has been chosen as the primary outcome measure in the European natural history study for Friedreich ataxia (FA). - Source: PubMed
Publication date: 2023/08/28
Porcu LucaFichera MarioNanetti LorenzoRulli ElianaGiunti PaolaParkinson Michael HDurr AlexandraEwenczyk ClaireBoesch SylviaNachbauer WolfgangIndelicato ElisabettaKlopstock ThomasStendel ClaudiaRodríguez de Rivera Francisco JavierSchöls LudgerFleszar ZofiaGiordano IlariaDidszun ClaireCastaldo AnnaRai MyriamKlockgether ThomasPandolfo MassimoSchulz Jörg BReetz KathrinMariotti Caterina - The big-headed turtle () is an endemic chelonian species in Asia. Unlike most other turtles in the world, is characterized with eagle-beak jaw, large head, and long tail. Although these unique characteristics are well recognized, the underlying genetic basis remains largely elusive. Here, we performed comparative genomic analysis between and other representative species, aiming to reveal the genetic basis of the unique morphological features. Our results revealed that the eagle-beak jaw is most likely enabled by combined effects of expansion of SFRP5, extraction of FGF11, and mutation of both ZFYVE16 and PAX6. Large head is supported by mutations of SETD2 and FGRF2 and copy number variations of six head circumference modulation-related genes (TGFBR2, Twist2, Rdh10, Gas1, Chst11, and SNAP25). The long tail is probably involved in a genetic network comprising Gdf11, Lin 28, and HoxC12, two of which showed a consistent expression pattern with a model organism (mice). These findings suggest that expansion, extraction, and mutation of those genes may have profound effects on unique phenotypes of . - Source: PubMed
Publication date: 2023/07/25
Gong ShipingGe YanWei YufengGao Yangchun - Indigenous pig populations in Hainan Province live in tropical climate conditions and a relatively closed geographical environment, which has contributed to the formation of some excellent characteristics, such as heat tolerance, strong disease resistance and excellent meat quality. Over the past few decades, the number of these pig populations has decreased sharply, largely due to a decrease in growth rate and poor lean meat percentage. For effective conservation of these genetic resources (such as heat tolerance, meat quality and disease resistance), the whole-genome sequencing data of 78 individuals from 3 native Chinese pig populations, including Wuzhishan (WZS), Tunchang (TC) and Dingan (DA), were obtained using a 150 bp paired-end platform, and 25 individuals from two foreign breeds, including Landrace (LR) and Large White (LW), were downloaded from a public database. A total of 28,384,282 SNPs were identified, of which 27,134,233 SNPs were identified in native Chinese pig populations. Both genetic diversity statistics and linkage disequilibrium (LD) analysis indicated that indigenous pig populations displayed high genetic diversity. The result of population structure implied the uniqueness of each native Chinese pig population. The selection signatures were detected between indigenous pig populations and foreign breeds by using the population differentiation index () method. A total of 359 candidate genes were identified, and some genes may affect characteristics such as immunity (, and ), adaptability (), reproduction (, , and ), meat quality (, , and ), and heat tolerance (, ). Overall, the findings of this study will provide some valuable insights for the future breeding, conservation and utilization of these three Chinese indigenous pig populations. - Source: PubMed
Publication date: 2023/06/16
Zhong ZiqiWang ZiyiXie XinfengTian ShuaishuaiWang FeifanWang QishanNi ShihengPan YuchunXiao Qian