Ask about this productRelated genes to: WRAP53 antibody
- Gene:
- WRAP53 NIH gene
- Name:
- WD repeat containing antisense to TP53
- Previous symbol:
- WDR79
- Synonyms:
- FLJ10385, TCAB1
- Chromosome:
- 17p13.1
- Locus Type:
- gene with protein product
- Date approved:
- 2005-08-12
- Date modifiied:
- 2019-04-23
Related products to: WRAP53 antibody
Related articles to: WRAP53 antibody
- Acute myeloid leukemia (AML) is a prevalent hematologic malignancy in adults, marked by clonal disorders in hematopoietic cells, rapid progression, and genetic heterogeneity. The WRAP53 gene, which is associated with genomic stability due to its involvement in activities, such as DNA repair, TP53 regulation, and association with telomerase (hTERT), was the focus of this study. - Source: PubMed
Gadelha Renan BritoNogueira Beatriz Maria DiasMachado Caio Bezerrade Pinho Pessoa Flávia Melo Cunhada Costa Machado Anna KarolynaLopes Germison SilvaRodrigues Paulo Henrique SilvaMartins Henrique Girãode Sousa Oliveira DeivideRibeiro Rodrigo MonteiroVieira Ricardo Parente Garciade Moraes Filho Manoel Odoricode Moraes Maria Elisabete AmaralKhayat André SalimMoreira-Nunes Caroline Aquino - Activation of the alternative lengthening of telomeres (ALT) pathway accounts for cellular immortalization in 75% of pediatric osteosarcoma. ALT does not rely on a single enzyme but instead, catalyzes telomere elongation via homologous recombination. There has been steady progress in defining the mechanisms that regulate the ALT pathway. However, the spectrum of genetic mutations that underlie activation of ALT remains unclear. Osteosarcomas, like many cancers, frequently harbor inactivating mutations in the tumor suppressor gene . However, instead of single nucleotide variants that lead to expression of mutant TP53 protein, osteosarcoma tumors often acquire unique structural variations within the first intron of the TP53 gene leading to complete gene inactivation. is located on chromosome 17p13.1 in a head-to-head orientation and partially overlapping with the gene (WD repeat containing antisense to TP53). WRAP53, also known as TCAB1, is an RNA chaperone that is an essential component of the telomerase holoenzyme. TCAB1 functions to facilitate trafficking of the telomerase RNA (hTR) within the nucleus to ensure assembly and localization of the telomerase enzyme to telomere ends to promote telomere elongation. Loss of TCAB1 function abolishes telomerase activity, driving progressive telomere attrition. Here, using whole-genome sequencing of osteosarcoma samples we identified SVs within the gene that not only compromise , but also inactivate . These SVs were prevalent in approximately 40% of ALT positive osteosarcoma tumors suggesting that functional inactivation of the telomerase holoenzyme may be an early and previously unrecognized event contributing to the activation of the ALT pathway. - Source: PubMed
Publication date: 2026/01/02
Keegan JoshuaSorbello SydneyMori JoakinMuratani ShugoLeshchiner IgnatyHeaphy Christopher MFlynn Rachel L - TCAB1 (telomerase Cajal body protein 1), encoded by the WRAP53 gene on chromosome 17p13.1, is a molecular scaffold critical for protein-nucleic acid interactions. In normal cells, TCAB1 plays a pivotal role in localizing telomerase to Cajal bodies, thereby ensuring proper telomere maintenance and genomic stability. In cancer cells, however, TCAB1 is frequently overexpressed, which supports unchecked proliferation and therapy resistance. Conversely, knockdown of TCAB1 triggers multiple tumor-suppressive mechanisms, including G1 cell cycle arrest - mediated by impaired p21 ubiquitination and subsequent Cyclin E/CDK2 inactivation - as well as telomere shortening and genomic instability due to mitochondrial dysfunction and defective DNA repair. Notably, the induction of cellular senescence emerges as a key anticancer mechanism upon TCAB1 depletion, particularly in early-stage tumors retaining wild-type p53. This review delineates the dual roles of TCAB1, highlighting its function as a context-dependent oncoprotein and the therapeutic potential of targeting it to induce senescence. - Source: PubMed
Publication date: 2026/01/05
Lin Mei-YuJiang DianTian NiniYao XiangPan Xing-HuaMa Li-HuaGao JingLi Zi-AnZhu Xiang-QinZhao Xi-LongRuan Guang-Ping - Telomerase is a ribonucleoprotein enzyme that maintains telomeric repeats on chromosome ends in continuously dividing cells. Telomere maintenance via telomerase is dependent on the correct assembly of the enzyme complex, complex stabilization by associated cofactors, and effective recruitment to the telomere. Here, we show that telomerase is regulated in each of these processes by the Drosophila behaviour/human splicing (DBHS) family of RNA/DNA binding proteins (NONO, SFPQ and PSPC1). The DBHS proteins associate with catalytically active telomerase through the hTR RNA template component. Cells lacking the DBHS proteins display telomerase retention in nuclear Cajal bodies and impaired telomerase recruitment to the telomere, with NONO and PSPC1 depletion culminating in progressive telomere shortening in several cell lines, with the exception of long-term NONO depletion in 293 and 293T. Our results reveal the DBHS protein family as components of the telomerase trafficking machinery integral to telomere maintenance. - Source: PubMed
Publication date: 2025/07/01
Sobinoff Alexander PWells Jadon KChow MauriceNelson Christopher BWu XinyiCohen Scott BLau Yu HengBryan Tracy MFox ArchaPickett Hilda A - The consumption of nuts has beneficial effects on cardiovascular health, body composition, cognitive functions, the intestinal microbiota, and satiety control, but how nuts and their nutrients impact related gene expression is unclear. - Source: PubMed
Wendling Aline LageRibeiro Madalena Geralda CupertinoKravchychyn Ana Claudia PelissariHermsdorff Helen Hermana Miranda