Ask about this productRelated genes to: WDR68 antibody
- Gene:
- DCAF7 NIH gene
- Name:
- DDB1 and CUL4 associated factor 7
- Previous symbol:
- WDR68
- Synonyms:
- HAN11, SWAN-1
- Chromosome:
- 17q23.3
- Locus Type:
- gene with protein product
- Date approved:
- 2005-05-26
- Date modifiied:
- 2015-07-09
Related products to: WDR68 antibody
Related articles to: WDR68 antibody
- Atherosclerosis (AS) poses a significant risk to human health. Our study, through the analysis of publicly available datasets, discovered that apoptosis plays a crucial role in the development of atherosclerosis. Additionally, we found that the iron apoptosis factor SLC40A1 is greatly increased, while the up-regulation of DCAF7 may be a significant contributing element to this impact. Therefore, we conducted tests both in vivo and in vitro to show that DCAF7 has the ability to influence the expression of SLC40A1 by impacting TNF and controlling the function of NF-κB, resulting in apoptosis. Following the creation of ApoE-/- mice, we suppressed the activity of DCAF7 and observed a substantial reduction in the advancement of carotid atherosclerosis and apoptosis in these animals. This suggests that DCAF7 plays a crucial role in the development of carotid atherosclerosis. Targeting DCAF7 has the potential to halt the progression of atherosclerosis. - Source: PubMed
Publication date: 2026/06/19
Guo SienYan PengNiu GengchenLi BiqiWu NiYao QisenWang ShengyuanHu ChongyuanZheng YishengYan YiheLi HuafuWang Chunming - Hepatocellular carcinoma (HCC) predominantly arises in individuals with chronic liver diseases and cirrhosis. Long non-coding RNAs (lncRNAs) have emerged as critical regulators of gene expression and play pivotal roles in cancer biology. The present study aimed to investigate the role of LINC01184 in modulating cell malignancy and xenograft tumor growth in HCC. - Source: PubMed
Publication date: 2026/04/15
Wang BingZou XunXiao Yuanchu - BACKGROUND: TCOF1 is a nucleolar protein involved in ribosome biogenesis, DNA damage response, and mitotic regulation. Germline TCOF1 mutations are associated with Treacher-Collins syndrome, a rare congenital disorder characterized by craniofacial abnormalities. Clear cell renal cell carcinoma (ccRCC), the most prevalent form of kidney cancer, exhibits pronounced nuclear and nucleolar pleomorphism, which correlates with tumour aggressiveness. The ccRCC grading system relies on microscopic evaluation of nuclear and nucleolar features. Here, we hypothesized that TCOF1 contributes to ccRCC tumorigenesis. METHODS: The study involved 200 tissue samples from ccRCC patients, two ccRCC-derived cell lines, and the publicly available cancer datasets. The used techniques included siRNA transfections, proliferation, viability, migration, and adhesion assays, proteomic and transcriptomic analyses, Western blot, real-time PCR, and angiogenesis evaluation using HUVEC cells. RESULTS: TCOF1 expression was elevated in ccRCC tumours and correlated with higher nucleolar grade and poorer patient survival. TCOF1 depletion altered the expression of multiple genes and proteins involved in the Golgi secretory pathway, including AVL9, GOLGA4, GOPC, RPS6KA5, SCAMP1, SEC24B, and STEAP3. These changes led to enhanced secretion of the anti-angiogenic thrombospondin 1 and suppression of angiogenesis. Furthermore, TCOF1 silencing downregulated several proteins implicated in craniofacial development, such as DCAF7 (aka WDR68), CHUK, APAF1, DICER1, and ETS1. CONCLUSIONS: To our knowledge, this is the first study linking a nucleolar TCOF1 protein to the regulation of cellular secretion. Our findings suggest that elevated TCOF1 expression may disrupt the Golgi secretory pathway, inhibit thrombospondin 1 secretion, and promote angiogenesis in ccRCC. Our study also contributes to the understanding of the molecular consequences of TCOF1 dysfunction in Treacher-Collins syndrome. - Source: PubMed
Publication date: 2026/03/17
Grzanka MałgorzataPopławski PiotrWiśniewski Jacek RIwanicka-Nowicka RoksanaKossowska HelenaKoblowska MartaRybicka BeataBiałas AlexPiekiełko-Witkowska Agnieszka - Cell motility is critical for physiological processes including wound healing. However, high concentrations of motility-promoting agents may suppress cellular migration; this newly observed phenomenon warrants further characterization. - Source: PubMed
Publication date: 2026/02/04
Li Chang-ZhiZhou Hong-JuanChen Jin-DongHuang JieLiu Yi-XiuQian Chao-Nan - DDB1 and CUL4-associated factor 7 (DCAF7) is a WD-repeat adaptor that recruits substrates to the CUL4DDB1 ubiquitinligase complex, but its pan-cancer relevance and mechanistic contribution to tumor progression remain unclear. - Source: PubMed
Luan RuinaLin HanbinZhao XinLi JianpengChen MaoheLuo ShipingLin Xinjian