Ask about this productRelated genes to: WDR21C antibody
- Gene:
- DCAF4L2 NIH gene
- Name:
- DDB1 and CUL4 associated factor 4 like 2
- Previous symbol:
- WDR21C
- Synonyms:
- -
- Chromosome:
- 8q21.3
- Locus Type:
- gene with protein product
- Date approved:
- 2005-04-21
- Date modifiied:
- 2016-10-25
Related products to: WDR21C antibody
Related articles to: WDR21C antibody
- This study aimed to evaluate the prognostic value of plasma circulating tumor DNA (ctDNA) level in patients with resectable gastric cancer (GC). A total of 59 patients were prospectively enrolled, with their ctDNA detected and paired tumor tissue collected at various peri-operative time points. Patients with higher 1-month post-operative ctDNA levels demonstrated shorter overall survival status (hazard ratio [HR] = 5.30, = 0.0022) and a higher risk of recurrence (HR = 3.85, = 0.011). The model combining ctDNA with conventional serum tumor markers for GC, including carcinoembryonic antigen, carbohydrate antigen 19-9, and CA72-4, shows high predictive effectiveness for GC prognosis with an area under the curve of 0.940 ( = 0.002), which is higher than net ctDNA and other models without ctDNA. Patients with lower ctDNA levels were more likely to have positive stromal programmed cell death ligand 1 expression ( = 0.046). Additionally, DCAF4L2 mutation was identified as the crucial gene mutation in ctDNA suggesting poor prognosis of patients with GC. Overall, this study highlights that post-operative ctDNA can serve as an effective biomarker for prognostic prediction and recurrence surveillance in resectable GC. - Source: PubMed
Publication date: 2025/01/19
Liu ZhengShi ZhongyiJiang WenchaoShen ZhenbinChen WeidongShen KuntangSun YihongTang ZhaoqingWang Xuefei - Nonsyndromic orofacial clefts (OFCs) are among the most common craniofacial birth defects worldwide, and known to exhibit phenotypic and genetic heterogeneity. Cleft lip plus cleft palate (CLP) and cleft lip only (CL) are commonly combined together as one phenotype (CL/P), separately from cleft palate alone. In comparison, our study analyzes CL and CLP separately. A sample of 2218 CL and CLP cases, 4537 unaffected relatives of cases, and 2673 pure controls with no family history of OFC were selected from the Pittsburgh Orofacial Cleft (Pitt-OFC) multiethnic study.genome-wide association studies were run for seven specific phenotypes created based on the cleft type(s) observed within these families, as well as the combined CL/P phenotype. Five novel genome-wide significant associations, 3q29 (rs62284390), 5p13.2 (rs609659), 7q22.1 (rs6465810), 19p13.3 (rs628271), and 20q13.33 (rs2427238), and nine associations (p ≤ 1.0E-05) within previously confirmed OFC loci-PAX7, IRF6, FAM49A, DCAF4L2, 8q24.21, ARID3B, NTN1, TANC2 and the WNT9B:WNT3 gene cluster-were observed. We also found that single nucleotide polymorphisms within a subset of the associated loci, both previously known and novel, differ substantially in terms of their effects across cleft- or family-specific phenotypes, indicating not only etiologic differences between CL and CLP, but also genetic heterogeneity within each of the two OFC subtypes. - Source: PubMed
Publication date: 2022/02/22
Mukhopadhyay NanditaFeingold EleanorMoreno-Uribe LinaWehby GeorgeValencia-Ramirez Luz ConsueloRestrepo Muñeton Claudia PPadilla CarmencitaDeleyiannis FredericChristensen KaarePoletta Fernando AOrioli Ieda MHecht Jacqueline TBuxó Carmen JButali AzeezAdeyemo Wasiu LVieira Alexandre RShaffer John RMurray Jeffrey CWeinberg Seth MLeslie Elizabeth JMarazita Mary L - Orofacial clefts (OFCs) are among the most prevalent craniofacial birth defects worldwide and create a significant public health burden. The majority of OFCs are non-syndromic and vary in prevalence by ethnicity. Africans have the lowest prevalence of OFCs (~ 1/2,500), Asians have the highest prevalence (~1/500), Europeans and Latin Americans lie somewhere in the middle (~1/800 and 1/900, respectively). Thus, ethnicity appears to be a major determinant of the risk of developing OFC. The Pittsburgh Orofacial Clefts Multiethnic study was designed to explore this ethnic variance, comprising a large number of families and individuals (~12,000 individuals) from multiple populations worldwide: US and Europe, Asians, mixed Native American/Caucasians, and Africans. In this current study, we analyzed 2,915 OFC cases, 6,044 unaffected individuals related to the OFC cases, and 2,685 controls with no personal or family history of OFC. Participants were grouped by their ancestry into African, Asian, European, and Central and South American subsets, and genome-wide association run on the combined sample as well as the four ancestry-based groups. We observed 22 associations to cleft lip with or without cleft palate at 18 distinct loci with -values < 1e-06, including 10 with genome-wide significance (<5e-08), in the combined sample and within ancestry groups. Three loci - 2p12 (rs62164740, = 6.27e-07), 10q22.2 (rs150952246, = 3.14e-07), and 10q24.32 (rs118107597, = 8.21e-07) are novel. Nine were in or near known OFC loci - , 8q24.21, , and . The majority of the associations were observed only in the combined sample, European, and Central and South American groups. We investigated whether the observed differences in association strength were (a) purely due to sample sizes, (b) due to systematic allele frequency difference at the population level, or (c) due to the fact certain OFC-causing variants confer different amounts of risk depending on ancestral origin, by comparing effect sizes to observed allele frequencies of the effect allele in our ancestry-based groups. While some of the associations differ due to systematic differences in allele frequencies between groups, others show variation in effect size despite similar frequencies across ancestry groups. - Source: PubMed
Publication date: 2021/04/09
Mukhopadhyay NanditaFeingold EleanorMoreno-Uribe LinaWehby GeorgeValencia-Ramirez Luz ConsueloMuñeton Claudia P RestrepoPadilla CarmencitaDeleyiannis FredericChristensen KaarePoletta Fernando AOrioli Ieda MHecht Jacqueline TBuxó Carmen JButali AzeezAdeyemo Wasiu LVieira Alexandre RShaffer John RMurray Jeffrey CWeinberg Seth MLeslie Elizabeth JMarazita Mary L - Hepatocellular carcinoma (HCC) is the most prevalent type of liver cancer. In this study, we aimed to explore the role and mechanism of lncRNA ST8SIA6-AS1 in HCC. We found that ST8SIA6-AS1 was upregulated in HCC tissues and associated with poorer overall survival of HCC patients from TCGA. Moreover, ST8SIA6-AS1 was highly expressed in HCC in-house tissues and cells, and ST8SIA6-AS1 upregulation was related to aggressive tumor phenotypes and the poor overall survival of HCC patients. Downregulation of ST8SIA6-AS1 suppressed HCC cell proliferation, migration and invasion in vitro and restrained HCC tumorigenesis in vivo. In terms of mechanism, ST8SIA6-AS1 regulated melanoma-associated antigen (MAGE)-A3 (MAGEA3) and DDB1-and Cul4-associated factor 4-like 2 (DCAF4L2) expression, and rescue experiments verified that ST8SIA6-AS1 played a protumorigenic role in HCC via the regulation of MAGEA3 and DCAF4L2. ST8SIA6-AS1 partly directly bound to miR-129-5p and functioned as a competing endogenous RNA (ceRNA), subsequently facilitating the expression of the miR-129-5p target gene DCAF4L2 to play its role in HCC. In summary, our results identified ST8SIA6-AS1 as an oncogenic lncRNA predicting poor clinical outcomes of patients with HCC. These findings suggest that ST8SIA6-AS1 is a potential therapeutic target for HCC. - Source: PubMed
Publication date: 2020/10/01
Zhang XiufenXu SuiHu CaixiaFang KaiZhou JunjingGuo ZijianZhu GuodingLi Lihua - The aim of this study was to investigate DNA methylation alterations in non-alcoholic steatohepatitis (NASH)-related hepatocellular carcinomas (HCCs). - Source: PubMed
Publication date: 2020/07/19
Tian YingArai EriMakiuchi SatomiTsuda NoboruKuramoto JunkoOhara KentaroTakahashi YorikoIto NanakoOjima HidenoriHiraoka NobuyoshiGotoh MasahiroYoshida TeruhikoKanai Yae