Ask about this productRelated genes to: WDR19 antibody
- Gene:
- WDR19 NIH gene
- Name:
- WD repeat domain 19
- Previous symbol:
- -
- Synonyms:
- Pwdmp, KIAA1638, FLJ23127, ORF26, DYF-2, Oseg6, IFT144, NPHP13
- Chromosome:
- 4p14
- Locus Type:
- gene with protein product
- Date approved:
- 2002-04-26
- Date modifiied:
- 2015-08-26
Related products to: WDR19 antibody
Related articles to: WDR19 antibody
- Investigation of in utero, tissue-specific molecular pathways contributing to prenatal programming of childhood-onset asthma is needed to develop effective, targeted prevention strategies. We aimed to examine the relationship between predicted gene expression in placenta and childhood-onset asthma and to compare relationships between childhood- and adult-onset asthma. Asthma genome-wide association study published summary statistics were obtained from the UK Biobank and published placental gene expression quantitative trait loci were obtained from the Rhode Island Child Health Study. We used S-PrediXcan to evaluate and compare associations between placental predicted gene expression and childhood- and adult-onset asthma and to determine whether signals were placenta-specific. Among 8,038 tested placental predicted expression-asthma associations, we identified 56 (0.7%) genes only significantly associated with childhood-onset asthma, 12 (0.1%) genes only significantly associated with adult-onset asthma, and 18 (0.2%) shared genes. Predicted expression of several genes (ACTL9, AMN, C9orf38, C11orf30, CTSE, EFCAB13, EIF4E1B, FN1, GLS2, IL6, IVL, LZIC, MAN2A2, MEGT1, RACGAP1, SMAD6, SPATA5, TMEM25, VTI1B, WDR19) was not significantly associated with childhood- or adult-onset asthma in any non-placental tissue, suggesting that the associations may be placenta-specific. This study identified alterations in predicted expression of placental genes associated with transcriptional pathways critical to the development of asthma. We identified unique and shared pathways, particularly related to immune regulation, associated with childhood- and adult-onset. This expands our understanding of the fetal origins of asthma, highlights the placenta as an informative tissue in understanding asthma pathogenesis, and identifies target genes to prioritize for future functional studies. - Source: PubMed
Publication date: 2026/05/13
Jasper Elizabeth AMcKennan Christopher GThompson Emma ESchoettler NathanGebretsadik TebebHellwege Jacklyn NEdwards Todd LOber CaroleVelez Edwards Digna RHartert Tina VSnyder Brittney M - Therapeutic resistance is a major cause of treatment failure in glioblastoma (GBM), highlighting the need for physiologically relevant models to identify actionable resistance mechanisms. While two-dimensional (2D) cultures are widely used for target discovery, they poorly represent the tumor microenvironment. In contrast, three-dimensional (3D) spheroid cultures better recapitulate spatial heterogeneity, hypoxic gradients, and stress-adaptive signaling observed in tumors. - Source: PubMed
Khotchawan WannawatRuengket PakornKheolamai PakpoomSathornsumetee SithSinthuvanich ChomdaoLorthongpanich ChanchaoIssaragrisil Surapol - An 8-year-old girl with growth failure and multisystem involvement was admitted to the Institute of Medical Genetics at Henan Provincial People's Hospital in May 2022. She presented with craniofacial abnormalities, language delay, and psychomotor retardation, suggestive of Sensenbrenner syndrome. Whole-exome sequencing and Sanger sequencing performed on the family revealed that the proband carried two novel compound heterozygous mutations in the WDR19 gene: c.1574A>G (p.Asn525Ser) and c.196G>A (p.Gly66Arg), inherited from her father and mother, respectively. Bioinformatics analysis indicated that the amino acids encoded by these two variants are highly conserved across multiple species and that these mutations may alter the secondary and tertiary structures of the protein, potentially affecting its phosphorylation and glycosylation properties. These findings suggest that these variants likely constitute the genetic basis underlying the clinical manifestations observed in the proband. The present case expands the known mutation spectrum of the WDR19 gene, provides new evidence for the diagnosis of Sensenbrenner syndrome. - Source: PubMed
Gao YGuo L JZhang M TSu J XLiu X MZhang BWang H D - Anti-Müllerian hormone (AMH) regulates ovarian follicle development, but AMH overexpression has been linked to impaired fertility and pregnancy failure. Our previous studies indicated that AMH overexpression hindered preimplantation embryo development. - Source: PubMed
Hore Timothy APankhurst Michael W - Variants in the gene, a crucial component of the intraflagellar transport (IFT) complex A, are associated with renal-cystic ciliopathies, a prevalent cause of renal failure of genetic origin. In the Arab Druze population, a pathogenic missense variant (c.878G>A; p.Cys293Tyr, termed ) is the most common genetic cause of kidney failure manifesting as adult-onset, typically nonsyndromic chronic kidney disease (CKD). The underlying pathogenesis of this condition remains unclear. - Source: PubMed
Publication date: 2025/07/24
Shlomovitz OmerBen-Haim YamEisenstein NetanelArmon LeahGrinberg IgorPolak-Charcon SylvieAtias-Varon DanitChowers GuyBen-Ruby DrorUrbach AchiaVivante Asaf