Ask about this productRelated genes to: WBSCR16 antibody
- Gene:
- RCC1L NIH gene
- Name:
- RCC1 like
- Previous symbol:
- WBSCR16
- Synonyms:
- -
- Chromosome:
- 7q11.23
- Locus Type:
- gene with protein product
- Date approved:
- 2001-08-08
- Date modifiied:
- 2018-11-23
Related products to: WBSCR16 antibody
Related articles to: WBSCR16 antibody
- Reproductive performance is a critical aspect of livestock production and sustainability. The number of stillbirths (NS) and mummified (NM) piglets significantly affect reproductive efficiency in swine production. Identifying and understanding the genetic architecture and candidate genes influencing these reproductive loss traits are essential for genetic inheritance studies and selective breeding programs in the swine breeding industry. To elucidate the genetic architecture of these traits, we performed a genome-wide association study (GWAS) using porcine 70 K BeadChip arrays from 1,162 Duroc, 1,783 Landrace, and 2,366 Yorkshire pigs. - Source: PubMed
Publication date: 2025/11/18
Mekonnen Kefala TayeLee Dong-HuiBeyenssa Befekadu ChemereSon Ah-YeongCho Young-GyuSeo Kang-Seok - Mitochondrial DNA (mtDNA) is organized with proteins into mitochondrial nucleoid (mt-nucleoid). The mt-nucleoid is a unit for the maintenance and function of mtDNA. The regulator of chromosome condensation 1-like protein (RCC1L) performs various functions in mitochondria, including translation, but its involvement in regulating mt-nucleoid maintenance is unknown. Herein, we found that human RCC1L was required to maintain mt-nucleoids and mtDNA. Human RCC1L has three splicing isoforms: RCC1L, RCC1L, and RCC1L. Knockout (KO) cells lacking all RCC1L isoforms, which were lethal without pyruvate and uridine, exhibited a decrease in mt-nucleoids and mtDNA, along with swollen and fragmented mitochondria. Among the three RCC1L isoforms, only RCC1L recovered all phenotypes observed in RCC1L KO cells. As the treatment of wild-type cells with chloramphenicol, a mitochondrial translation inhibitor, did not lead to the decrease in mt-nucleoids accompanied by mtDNA depletion, the decrease in mt-nucleoids and mtDNA in RCC1L KO cells was not solely attributed to impaired mitochondrial translation. Using conditional RCC1L KO cells, we observed a rapid decrease in mt-nucleoids and mtDNA during a specific period following RCC1L loss. Our findings indicate that RCC1L regulates the maintenance of mt-nucleoids and mtDNA besides its role in mitochondrial translational regulation. - Source: PubMed
Publication date: 2025/04/21
Matsumoto EmiSasaki TaekoHigashiyama TetsuyaSasaki Narie - NME6 belongs to the family of nucleoside diphosphate kinase enzymes, whose major role is to transfer the terminal phosphate from NTPs, mostly ATP, to other (d)NDPs via a high-energy intermediate. Beside this basic enzymatic activity, the family, comprising 10 genes/proteins in humans, executes a number of diverse biochemical/biological functions in the cell. A few previous studies have reported that NME6 resides in the mitochondria and influences oxidative phosphorylation while interacting with RCC1L, a GTPase involved in mitochondrial ribosome assembly and translation. Considering the multifunctional role of NME family members, the goal of the present study was to assess the influence of the overexpression or silencing of NME6 on fundamental cellular events of MDA-MB-231T metastatic breast cancer cells. Using flow cytometry, Western blotting, and a wound-healing assay, we demonstrated that the overexpression of NME6 reduces cell migration and alters the expression of EMT (epithelial-mesenchymal transition) markers. In addition, NME6 overexpression influences cell cycle distribution exclusively upon DNA damage and impacts the MAPK/ERK signaling pathway, while it has no effect on apoptosis. To conclude, our results demonstrate that NME6 is involved in different cellular processes, providing a solid basis for future, more precise investigations of its role. - Source: PubMed
Publication date: 2024/09/04
Proust BastienHorvat AnđelaTadijan AnaVlašić IgnacijaHerak Bosnar Maja - Eukaryotic NMEs/NDP kinases are a family of 10 multifunctional proteins that occur in different cellular compartments and interact with various cellular components (proteins, membranes, and DNA). In contrast to the well-studied Group I NMEs (NME1-4), little is known about the more divergent Group II NMEs (NME5-9). Three recent publications now shed new light on NME6. First, NME6 is a third mitochondrial NME, largely localized in the matrix space, associated with the mitochondrial inner membrane. Second, while its monomeric form is inactive, NME6 gains NDP kinase activity through interaction with mitochondrial RCC1L. This challenges the current notion that mammalian NMEs require the formation of hexamers to become active. The formation of complexes between NME6 and RCC1L, likely heterodimers, seemingly obviates the necessity for hexamer formation, stabilizing a NDP kinase-competent conformation. Third, NME6 is involved in mitochondrial gene maintenance and expression by providing (d)NTPs for replication and transcription (in particular the pyrimidine nucleotides) and by a less characterized mechanism that supports mitoribosome function. This review offers an overview of NME evolution and structure and highlights the new insight into NME6. The new findings position NME6 as the most comprehensively studied protein in NME Group II and may even suggest it as a new paradigm for related family members. - Source: PubMed
Publication date: 2024/07/30
Proust BastienHerak Bosnar MajaĆetković HelenaTokarska-Schlattner MalgorzataSchlattner Uwe - To identify new genetic variants associated with SLE in Taiwan and establish polygenic risk score (PRS) models to improve the early diagnostic accuracy of SLE. - Source: PubMed
Publication date: 2024/05/09
Chen Yu-ChiaLiu Ting-YuanLu Hsing-FangHuang Chung-MingLiao Chi-ChouTsai Fuu-Jen