Ask about this productRelated genes to: VPS26A antibody
- Gene:
- VPS26A NIH gene
- Name:
- VPS26, retromer complex component A
- Previous symbol:
- VPS26
- Synonyms:
- Hbeta58, PEP8A
- Chromosome:
- 10q22.1
- Locus Type:
- gene with protein product
- Date approved:
- 2000-03-15
- Date modifiied:
- 2016-10-05
Related products to: VPS26A antibody
Related articles to: VPS26A antibody
- Many proteins can reach the cell surface through a Golgi-independent unconventional protein secretion (UPS) pathway, particularly under cellular stress conditions. However, the molecular mechanisms that mediate UPS remain largely elusive. In this study, VPS26A-containing retromer complex, along with the sorting nexin SNX27, is identified as a regulator of UPS of transmembrane proteins, including the trafficking-deficient ∆F508 mutant CFTR, which causes cystic fibrosis, and the SARS-CoV-2 spike protein, associated with COVID-19. A targeted CRISPR knockout screen identified VPS26A as a key contributor in the UPS of ∆F508-CFTR. Subsequent molecular analyses revealed that SNX27 recruits ∆F508-CFTR to the VPS26A-VPS35-VPS29 retromer complex, facilitating its transport to the cell surface under UPS-inducing conditions. Additionally, VPS26A and SNX27 are necessary for UPS of the spike protein, enabling the formation of intact SARS-CoV-2 virions. These findings suggest that the retromer complex and SNX27, known for their roles in recycling endosomes, mediate previously unrecognized functions in the UPS of transmembrane proteins. - Source: PubMed
Publication date: 2026/04/06
Kim Ye JinLee ChaeyoungSeo Soo KyungRoh Jae WonLee Hye RyungHwang Su JinChang NienpingChoi Hee SeongShin Dong HoonKim Hui KwonKim Han SangCho Hyun-SooLee Jae MyunGee Heon YungLee Min GooNoh Shin Hye - Gestational diabetes mellitus (GDM) is hyperglycaemia first identified during pregnancy. Because GDM and type 2 diabetes mellitus (T2DM) share insulin resistance and β-cell dysfunction, T2DM variants may also influence the risk of GDM. This study examined the association of three genome-wide association study (GWAS)-identified T2DM variants, AP3S2 rs2028299 (C>A), ST6GAL1 rs16861329 (C>T), and VPS26A rs1802295 (C>T), with GDM susceptibility in pregnant women from North India. - Source: PubMed
Publication date: 2026/01/18
Shakir ZoyaPandey AmitaA Alsayegh AbdulrahmanFahad Alshahrani AbrarAshfaq FauziaKhan MohammadAli Wahid - This case-control study investigated the association of three novel South Asian genome-wide association studies (GWAS)-derived type 2 diabetes mellitus (T2DM) susceptibility gene polymorphisms in the North Indian population. - Source: PubMed
Publication date: 2025/05/02
Shakir ZoyaSiddiqui Kauser UHimanshu DanduAli Wahid - VPS26A, a core component of the retromer complex, is pivotal to endosomal trafficking and membrane protein recycling. However, its expression profile, prognostic significance, and clinical relevance in liver hepatocellular carcinoma (LIHC) remain unexplored. This study investigates the prognostic potential of VPS26A by extensively analyzing publicly available LIHC-related databases. Multiple databases, including TIMER, UALCAN, HPA, GSCA, KM Plotter, OSlihc, MethSurv, miRNet, OncomiR, LinkedOmics, GeneMANIA, and STRING, were used to evaluate VPS26A expression patterns, prognostic implications, correlations with tumor-infiltrating immune cells (TIICs), epigenetic modifications, drug sensitivity, co-expression networks, and protein-protein interactions in LIHC. VPS26A was significantly overexpressed at both the mRNA and protein levels in LIHC tissues compared to that in normal tissues. This upregulation was strongly associated with a poor prognosis. Furthermore, VPS26A expression was both positively and negatively correlated with various TIICs. Epigenetic analysis indicated that VPS26A is regulated by promoter and regional DNA methylation. Additionally, VPS26A influences the sensitivity of LIHC cells to a broad range of anticancer agents. Functional enrichment and co-expression analyses revealed that VPS26A serves as a central regulator of the LIHC transcriptomic landscape, with positively correlated gene sets linked to poor prognosis. Additionally, VPS26A contributes to the molecular architecture governing vesicular trafficking, with potential relevance to diseases involving defects in endosomal transport and autophagy. Notably, miRNAs targeting VPS26A-associated gene networks have emerged as potential prognostic biomarkers for LIHC. VPS26A was found to be integrated into a highly interconnected signaling network comprising proteins in cancer progression, immune regulation, and cellular metabolism. Overall, VPS26A may serve as a potential prognostic biomarker and therapeutic target in LIHC. This study provides novel insights into the molecular mechanisms underlying LIHC progression, and highlights the multifaceted role of VPS26A in tumor biology. - Source: PubMed
Publication date: 2025/07/16
Kim Hye-RanKim Jongwan - ATG5 is one of the core autophagy proteins with additional functions such as noncanonical membrane atg8ylation, which among a growing number of biological outputs includes control of tuberculosis in animal models. Here, we show that ATG5 associates with retromer's core components VPS26, VPS29, and VPS35 and modulates retromer function. Knockout of ATG5 blocked trafficking of a key glucose transporter sorted by the retromer, GLUT1, to the plasma membrane. Knockouts of other genes essential for membrane atg8ylation, of which ATG5 is a component, affected GLUT1 sorting, indicating that membrane atg8ylation as a process affects retromer function and endosomal sorting. The contribution of membrane atg8ylation to retromer function in GLUT1 sorting was independent of canonical autophagy. These findings expand the scope of membrane atg8ylation to specific sorting processes in the cell dependent on the retromer and its known interactors. - Source: PubMed
Publication date: 2025/01/07
Paddar Masroor AhmadWang FulongTrosdal Einar SHendrix EmilyHe YiSalemi Michelle RMudd MichalJia JingyueDuque ThabataJaved RuheenaPhinney Brett SDeretic Vojo