Ask about this productRelated genes to: VASP antibody
- Gene:
- VASP NIH gene
- Name:
- vasodilator stimulated phosphoprotein
- Previous symbol:
- -
- Synonyms:
- -
- Chromosome:
- 19q13.32
- Locus Type:
- gene with protein product
- Date approved:
- 1996-06-07
- Date modifiied:
- 2017-06-13
Related products to: VASP antibody
Related articles to: VASP antibody
- Acute coronary syndrome (ACS) remains a leading cause of global morbidity and mortality, often managed with antiplatelet therapy. However, variability in patient response due to comorbidities, genetic polymorphisms, and resistance to antiplatelet agents creates challenges in optimizing treatment. - Source: PubMed
Publication date: 2026/04/20
Venissa Rebello JeenalShah AshnaKarattuthodi Mohammed SalimMai Chun-WaiElnaem Mohamed Hassan - Primary failure of eruption (PFE) is a rare autosomal disorder provoked by heterozygous mutations in the parathyroid hormone receptor 1 (PTH1R) gene. PTH1R is a G protein-coupled receptor (GPCR) which regulates intracellular signaling molecules like cAMP. By using CRISPR/Cas9, the pathogenic PTH1R variant, c.1050-3C>G, was introduced into the periodontal ligament (PDL-hTERT) cell line to investigate molecular mechanisms in a PFE in vitro model. The PDL-hTERT immortal cell line, derived from human primary PDL cells, is a well-established model for dental diseases and expresses PTH1R. We performed different functional assays to compare the behavior of the PDL-hTERT WT versus PTH1R-mutated cells. cAMP synthesis and PKA activation were compared between different cell lines by live-cell imaging using Förster Resonance Energy Transfer (FRET)-based biosensors. Phosphorylation of VASP was measured to validate and compare the PKA activation between the cell lines. In summary, our experiments show that the mutated cell line has no major phenotypic changes, but the PTH1R downstream signaling cascade is impaired. KEY MESSAGES: A rare autosomal disorder linked to mutations in the PTH1R gene, which encodes a G protein-coupled receptor regulating intracellular signaling, including cAMP production. The pathogenic PTH1R mutation (c.1050-3C>G) was introduced into a periodontal ligament (PDL hTERT) cell line to model PFE and study molecular mechanisms in vitro. Functional assay revealed that while the mutated cell line displayed no major phenotypic changes, the PTH1R downstream signaling cascade, including cAMP synthesis and PKA activation, was disrupted. Techniques like FRET-based biosensors and VASP phosphorylation assays highlighted specific impairments in signaling pathways in cells with the PTH1R mutations. - Source: PubMed
Publication date: 2026/04/20
Marnet KSubramanian HWiesler MBorst ALiedtke DPattappa GDocheva DNikolaev V OStellzig-Eisenhauer AEigenthaler MHerrmann M - Lithium-based compounds, such as LiO, LiS, LiN, and LiF, have important applications in the fields of semiconductors, optics and energy. By performing density functional theory calculations, the structures and properties of lithium-based compounds, including the crystalline, electronic, mechanical, and optical characteristics, were systematically investigated. The impact of oxygen doping on the structure and performance was further studied. The results revealed that doping can reduce their band gaps and elastic constants and change the magnetic properties and the optical moments. These insights can provide theoretical guidance for the design and development of novel lithium-based, sulfide, nitride and fluoride compounds. - Source: PubMed
Publication date: 2026/04/14
Bai ChenqiZhao YongxiaoGu SenzeWang DanlingGuo JiayiHu DanniWang YuXu LinaXiao HongpingFang Guoyong - The study presents a comprehensive computational analysis of CO adsorption on anatase TiO surfaces with the (001) and (111) facets, utilizing CO as an IR probe. CO adsorption orientations and binding strengths vary between surfaces due to differences in local surface geometries and Ti coordination environments. Detailed electronic structure analyses, including density of states and wavefunction visualizations, show that σ-donation dominates on the (111) [TiO] site. At the same time, π-backdonation is more prominent at the (111) [TiO] site, correlating with a blue shift of the CO stretching frequency for the (111) [TiO] site and a red shift for the (111) [TiO] site. Surface oxygen atoms are key contributors to π-backdonation. The results highlight the critical role of surface topography and coordination environment in governing CO adsorption behavior, extending previous insights into anatase surface chemistry. - Source: PubMed
Publication date: 2026/04/13
Vacek JaroslavHobza PavelNachtigallová Dana - In the pursuit of non-toxic and high-efficiency perovskite solar cell materials, this study investigates the enhancement of thermoelectric and optoelectronic properties of Zn-doped KSn Zn I ( = 0, 0.25, 0.5, 0.75, 1) perovskites. The study uses first-principles density functional theory (DFT) with the Vienna Simulation Package (VASP). Structural analysis confirms a transition from orthorhombic () to monoclinic () phases. All the compositions exhibit thermodynamic, mechanical, and dynamic stability. Electronic properties reveal a robust bandgap range of 1.47-1.96 eV (GGA-PBEsol) and 2.34-3.02 eV (HSE06), positioning these materials as promising candidates for the top cell in a tandem solar cell and UV-optoelectronics. An indirect-to-direct band structure transition occurs at 50% Zn doping, which primarily enhances the stiffness, Pugh's ratio (2.39-2.70), and Poisson's (0.316-0.335) ratio of the lattice for KSn Zn I. The elastic modulus (), shear modulus (), and bulk modulus () in KSn Zn I also significantly increased upon addition of Zn in the compound. These behaviors indicate that although there is better lattice stiffness in the material, there is still very good ductility for making flexible devices. Near-perfect mechanical isotropy has been achieved in KZnI with a universal elastic anisotropy factor ( ) of only 0.15. This low level of anisotropic elastic behavior indicates that KZnI is unlikely to experience micro- fracture during or after manufacturing. Thermoelectric analysis shows that KSnI maintained a high Seebeck coefficient of 230 µV K at low temperature, while KZnI showed a 225 µV K Seebeck coefficient at elevated temperature. A high figure of merit () is achieved by both pristine compounds at high temperature, with values of 1.01 for KSnI and 1.27 for KZnI. Furthermore, for optical properties, a high absorption coefficient of 7.32 × 10 cm is observed by 25% Zn doping at UV-visible range. These findings make Zn-doped KSnI perovskite material suitable for efficient, non-toxic, low-cost optoelectronic and thermoelectric devices. - Source: PubMed
Publication date: 2026/04/08
Ahmed UsamaSayem Rahman Abu Sadat MdJui Jesia AlamHossain Md MukterUddin Md MohiAli Md Ashraf