Ask about this productRelated genes to: VANGL1 antibody
- Gene:
- VANGL1 NIH gene
- Name:
- VANGL planar cell polarity protein 1
- Previous symbol:
- -
- Synonyms:
- STB2
- Chromosome:
- 1p13.1
- Locus Type:
- gene with protein product
- Date approved:
- 2001-04-06
- Date modifiied:
- 2014-11-19
Related products to: VANGL1 antibody
Related articles to: VANGL1 antibody
- Osteosarcoma (OS) is a malignant bone tumor originating directly from bone tissue, predominantly affecting adolescents. Cisplatin (DDP)-based chemotherapy is commonly used in the treatment of OS, but the emergence of DDP resistance poses a significant challenge to effective management. The study aimed to investigate the role of circRNA VANGL1 (circVANGL1) in mediating DDP resistance in OS in vitro. - Source: PubMed
Publication date: 2026/05/06
Mo FanWang HaoXie QiHuang DahongYang Yuan - Planar cell polarity (PCP) proteins, including Van Gogh-like and frizzled, orient sensory hair cells in the inner ear. Because most PCP mouse models die at birth, orientation defects have been studied mainly at fetal stages. Using viable conditional mutants lacking both Vangl1 and Vangl2, or Fzd3 and Fzd6, we show that misoriented auditory hair cells undergo extensive postnatal reorientation, largely correcting defects over time. These findings extend previous observations in Vangl2 single conditional mutants and demonstrate that correction does not require redundant core PCP partners. GPR156, a receptor that reverses how PCP signaling is interpreted in some hair cell types, is also essential for orientation but Gpr156 mutants fail to correct defects. We therefore tested its role in core PCP mutant recovery. GPR156 binds and depends on VANGL proteins, yet inhibiting GPR156 signaling facilitates rather than prevents correction in Vangl and Fzd mutants. Thus, GPR156 collaborates with core PCP components to establish hair cell orientation but is dispensable - and even inhibitory - for postnatal realignment. These findings reveal extensive plasticity in hair cell orientation and identify GPR156 as a context-dependent partner of core PCP proteins. - Source: PubMed
Publication date: 2026/05/14
Jarysta AmandineNemelka JustinRamanathan MuthumeenaGoodrich Ellison JVonderhaar Brianna LPark SungjinOrlandi CesareDeans Michael RTarchini Basile - The PRICKLE proteins (PRICKLE1-PRICKLE4) play essential roles in the WNT/planar cell polarity (WNT/PCP) pathway in vertebrates. This signaling system governs cell polarity, tissue architecture, and coordinated cell movements, yet the specific roles and molecular mechanisms of individual PRICKLE members within this pathway are poorly understood. Here, we identify PRICKLE3 as a previously unrecognized, central regulator of WNT/PCP signaling in human cells, Xenopus laevis and zebrafish (Danio rerio) embryos. Using enhanced proximity biotinylation (miniTurboID) combined with mass spectrometry, we found PRICKLE3 enriched at the plasma membrane, where it associates with core WNT/PCP proteins, including VANGL1 and VANGL2. Through immunoblotting, live imaging and functional assays, we further demonstrated that PRICKLE3 selectively enhances VANGL1/2 stability by protecting them from Casein kinase 1ε (CK1ε)-mediated phosphorylation. Mechanistically, PRICKLE3 modulates an interaction network involving VANGL1/2, CK1ε, and the ubiquitin ligase RNF43, thereby increasing VANGL stabilization and accumulation at the plasma membrane. These effects were unique to PRICKLE3, as PRICKLE1 showed no comparable activity. Together, our findings reveal a PRICKLE3-specific mechanism that couples CK1ε inhibition with RNF43 suppression to stabilize VANGL complexes. We also provide a comprehensive interactome and molecular tools to support further functional dissection of the PRICKLE family in development and disease. - Source: PubMed
Publication date: 2025/12/27
Radaszkiewicz Katarzyna ARadaszkiewicz Tomasz WKolářová PavlaPaclíková PetraGömöryová KristínaNovotná ŠárkaMaia Lorena AgostiniČíhalová TerezaLe YaoBárta TomášHanáková KateřinaHýsková AnnaTripsianes KonstantinosZdráhal ZbyněkWinkler ChristophHarnoš Jakub - D. Yang, H. Qian, Z. Fang, A. Xu, S. Zhao, B. Liu and D. Li, "Silencing Circular RNA VANGL1 Inhibits Progression of Bladder Cancer by Regulating miR-1184/IGFBP2 Axis," Cancer Medicine 9, no. 2 (2020): 700-710, https://doi.org/10.1002/cam4.2650. The above article, published online on 23 November 2019 in Wiley Online Library (wileyonlinelibrary.com), has been retracted by agreement between the journal Editor-in-Chief, Stephen Tait; and John Wiley & Sons Ltd. The retraction has been agreed upon due to image overlaps within Figure 2F, as well as between images presented in Figures 2E and 5E. Furthermore, an image from Figure 5F appeared in another article, depicting a different scientific context, and the GAPDH western blot bands in Figure 2B were also identified in a separate publication. Both duplications were found in earlier articles published by different author groups. While the authors cooperated with our investigation and provided some data, they were unable to explain the duplications found in other articles. Due to the nature and extent of these concerns, the editors have lost confidence in the results and conclusions reported in this study. The authors disagree with the retraction. - Source: PubMed
- Skin aging is characterized by observable major changes in the composition and organization of the skin, including the appearance of wrinkles, tissue sagging, dryness, and pigmentary disorders. While both environmental and genetic factors contribute to these changes, their interaction remains underexplored. Perceived age is a biomarker of health and strongly related to facial skin aging features. Thus, we conducted a gene-environment interaction analysis on the perceived facial aging progression phenotype in 226 women, focusing on sun exposure as the environmental factor. - Source: PubMed
Publication date: 2025/07/23
Obry LudivineMedina-Santos RaissaRahmouni MyriamNoirel JosselinLabib ToufikGalan PilarSpadoni Jean-LouisGendronneau GaëlleJdid RandaCourrèges SandraLatreille JulieAndré NadaZagury Jean-FrançoisLe Clerc Sigrid