Ask about this productRelated genes to: VANGL1 antibody
- Gene:
- VANGL1 NIH gene
- Name:
- VANGL planar cell polarity protein 1
- Previous symbol:
- -
- Synonyms:
- STB2
- Chromosome:
- 1p13.1
- Locus Type:
- gene with protein product
- Date approved:
- 2001-04-06
- Date modifiied:
- 2014-11-19
Related products to: VANGL1 antibody
Related articles to: VANGL1 antibody
- The luminal epithelium of the oviduct exhibits ciliary beating oriented along the ovary-uterus (O-U) axis, driving oocyte transport toward the uterus. Longitudinal epithelial folds have also been proposed to facilitate this transport, but their functional contribution has not been tested because the mechanisms that orient these folds remain unclear. In this study, we found that in oviducts, which lack the core planar cell polarity (PCP) protein VANGL1, ciliary beating orientation is largely preserved, whereas longitudinal folds are disrupted. Despite fold malformation, females were able to produce offspring, suggesting that oocyte transport to the uterus can occur even when longitudinal fold alignment is disrupted. Polarized distributions of core PCP proteins at cell boundaries have been proposed to establish O-U-oriented ciliary beating and cell elongation, and theoretical work predicts that O-U-aligned cell elongation drives longitudinal fold formation. Consistent with this, our three-dimensional cell-shape analysis revealed a loss of cell elongation in oviducts. Moreover, although other core PCP proteins remained polarized, their polarity axes were misaligned with ciliary orientation in oviducts, suggesting that ciliary orientation can be guided by mechanisms that are at least partly independent of canonical core-protein polarity. Together, our findings help define the physiological contribution of longitudinal folds and illuminate how distinct polarity systems-fold orientation, cell elongation, and ciliary beating-are established and coordinated in the oviduct. - Source: PubMed
Publication date: 2026/08/04
Usami Fumiko MatsukawaArata MasakiKato KagayakiShi DongboOka SanaeYang YingziFujimori Toshihiko - Reproduction traits constitute the primary objective of porcine genetic improvement programs, with litter size being the principal determinant of herd reproduction output. Relative to the intensively selected Large White line, as a breed derived from Large White (LW) and Beijing Black (BJB) pigs, Jishen Black (JSB) pigs exhibit markedly lower litter size, indicating substantial potential for genetic improvement. - Source: PubMed
Publication date: 2026/06/29
Chen ChangyiZhang XiaoranLi JingKe JuanSun HaoBai ChunyanSun Boxing - The tumor microenvironment (TME) critically determines cancer progression, yet master regulators orchestrating microenvironmental remodeling across malignancies remain elusive. VANGL1, a core planar cell polarity component, has been implicated in tissue morphogenesis, but its pan-cancer landscape and TME regulatory mechanisms are unexplored. - Source: PubMed
Publication date: 2026/05/29
Zhou WeiWang LizhenLi MengxingLiu XuanFang QingYu YangZhang SongjieGuo JingChang RuiZhang ChengZhou TongliangLiu YangRen XiaoxiaLiu HonglinLiu Lihong - Osteosarcoma (OS) is a malignant bone tumor originating directly from bone tissue, predominantly affecting adolescents. Cisplatin (DDP)-based chemotherapy is commonly used in the treatment of OS, but the emergence of DDP resistance poses a significant challenge to effective management. The study aimed to investigate the role of circRNA VANGL1 (circVANGL1) in mediating DDP resistance in OS in vitro. - Source: PubMed
Publication date: 2026/05/06
Mo FanWang HaoXie QiHuang DahongYang Yuan - Planar cell polarity (PCP) proteins, including Van Gogh-like and frizzled, orient sensory hair cells in the inner ear. Because most PCP mouse models die at birth, orientation defects have been studied mainly at fetal stages. Using viable conditional mutants lacking both Vangl1 and Vangl2, or Fzd3 and Fzd6, we show that misoriented auditory hair cells undergo extensive postnatal reorientation, largely correcting defects over time. These findings extend previous observations in Vangl2 single conditional mutants and demonstrate that correction does not require redundant core PCP partners. GPR156, a receptor that reverses how PCP signaling is interpreted in some hair cell types, is also essential for orientation but Gpr156 mutants fail to correct defects. We therefore tested its role in core PCP mutant recovery. GPR156 binds and depends on VANGL proteins, yet inhibiting GPR156 signaling facilitates rather than prevents correction in Vangl and Fzd mutants. Thus, GPR156 collaborates with core PCP components to establish hair cell orientation but is dispensable - and even inhibitory - for postnatal realignment. These findings reveal extensive plasticity in hair cell orientation and identify GPR156 as a context-dependent partner of core PCP proteins. - Source: PubMed
Publication date: 2026/05/14
Jarysta AmandineNemelka JustinRamanathan MuthumeenaGoodrich Ellison JVonderhaar Brianna LPark SungjinOrlandi CesareDeans Michael RTarchini Basile