Ask about this productRelated genes to: VAMP5 antibody
- Gene:
- VAMP5 NIH gene
- Name:
- vesicle associated membrane protein 5
- Previous symbol:
- -
- Synonyms:
- -
- Chromosome:
- 2p11.2
- Locus Type:
- gene with protein product
- Date approved:
- 1999-07-22
- Date modifiied:
- 2015-11-05
Related products to: VAMP5 antibody
Related articles to: VAMP5 antibody
- Graft-versus-host disease (GVHD), a major adverse event following allogeneic hematopoietic stem cell transplantation (allo-HSCT), commonly affects leukemia patients and is associated with reduced survival and impaired quality of life. Early prediction of GVHD remains a major clinical challenge. - Source: PubMed
Publication date: 2026/03/12
Lu WeiHe ZhipengHuang Xianbao - Pancreatic ductal adenocarcinoma (PDAC) is ranked by the lowest 5-year survival rate worldwide. Given the lack of early symptoms and diagnostic biomarkers, most patients present with either local or distant metastasis at diagnosis. We previously demonstrated that Galectin-3-binding protein (Gal-3BP) is overexpressed in PDAC cells and promotes metastasis through the EGFR pathway, using proteomic analysis of PDAC tumor interstitial fluid (TIF). In the present study, we show the Gal-3BP promotes angiogenesis in PDAC by vascular endothelial growth factor A (VEGFA) upregulation via STAT3 activation. Furthermore, we reveal the Gal-3BP directly promotes migration and tube formation of vascular endothelial cells through STAT3 phosphorylation, mediated not by a VEGF receptor but by VAMP5. To explore the clinical application of these findings, we developed a humanized, high-affinity Gal-3BP antibody to block the dual angiogenic function of Gal-3BP. The #132 clone of the Gal-3BP antibody significantly reduced blood vessel density in PDAC orthotopic tumors and attenuated PDAC metastasis in a lung metastasis model. Therefore, we demonstrate the antibody-mediated blockade of Gal-3BP attenuates the angiogenesis in PDAC and propose it as a novel therapeutic strategy. - Source: PubMed
Publication date: 2026/03/18
Lim Ye JinSon Dong WooLee Eun JiYu Chae WonOh Yun OkCha Min JungKim HyoriKim KyunggonChang Suhwan - Skeletal muscle is a central regulator of metabolic health, serving as the primary site of postprandial glucose uptake and playing a critical role in whole-body insulin sensitivity. Despite its importance, the molecular mechanisms governing muscle differentiation (myogenesis) and their modulation by metabolic interventions remain poorly defined. This study identifies the clathrin adaptor protein Picalm (phosphatidylinositol-binding clathrin assembly protein) as a novel regulator of myogenesis and investigates its regulation in response to exercise training and intermittent fasting. - Source: PubMed
Publication date: 2026/03/13
Gaugel JasminHaacke NeeleKuropka BennoJähnert MarkusRominger JuliaJonas WenkeSpeckmann ThiloRausch NiclasKleinert MaximilianWeigert CoraGarcia-Carrizo FranciscoSchulz Tim JEbner MichaelFreund ChristianSchürmann AnnetteVogel Heike - Glioma is the most common and aggressive primary brain tumor, characterized by high heterogeneity, invasive growth, and poor prognosis. Identifying novel molecular drivers is essential for improving diagnosis, prognosis, and treatment. This study aimed to investigate the expression pattern, clinical significance, and functional role of VAMP5 in glioma. - Source: PubMed
Publication date: 2025/12/30
Ji YujieDai XiangyuZeng HaixinLiu ZhentaoCai ZhengLi Bing - Sarcopenia and frailty are complex geriatric syndromes influenced by a combination of genetic and environmental factors. Recent studies suggest that specific genetic variants, DNA methylation patterns and shortened telomeres are associated with age-related diseases and might contribute to the development of both sarcopenia and frailty. In this study, we investigated the contribution of multi-omics data to sarcopenia, frailty, lean mass index (LMI) and handgrip strength in an elderly Lithuanian population. A total of 204 participants (age 82.2 ± 7.6 years) were included, comprising 122 individuals diagnosed with sarcopenia and/or frailty and 82 healthy, community-dwelling older adults. The results showed that LMI was associated with various health and lifestyle factors. Two genetic variants, CLIC5 rs75652203 and GHITM rs17102732, were found to be significantly associated with handgrip strength at the genome-wide level. Additionally, 12 polymorphisms previously linked to sarcopenia were replicated in relationship to LMI: BOK rs76993203, VAMP5 rs1374370, TMEM18 rs12714414, SFMBT1 rs36033494, BANK1 rs13136118, TET2 rs2647239, FOXO3 rs9384679, L3MBTL3 rs13209574, ZFAT rs13267329, CEP57 rs35793328, PCGF2 rs1985352 and MC4R rs66922415. Furthermore, several genes, many of which are involved in immune system processes, were significantly enriched with differentially methylated sites associated with LMI. Shorter telomeres were also associated with both sarcopenia and frailty. Notably, a significant relationship was observed between telomere length and methylation levels in genes related to lifestyle traits and the risk of developing these conditions. These findings provide new insights into the biological mechanisms underlying sarcopenia and frailty, underscoring the important roles of genetic and epigenetic factors in their pathogenesis among older adults. - Source: PubMed
Publication date: 2025/09/27
Ginevičienė ValentinaPranckevičienė ErinijaUrnikytė AlinaJurkūnaitė LauraGutauskaitė KristijonaDadelienė RūtaKilaitė JustinaJamontaitė Ieva EglėMastavičiūtė AstaAhmetov Ildus IAlekna Vidmantas