Ask about this productRelated genes to: VAC14 antibody
- Gene:
- VAC14 NIH gene
- Name:
- VAC14 component of PIKFYVE complex
- Previous symbol:
- TAX1BP2
- Synonyms:
- FLJ10305, ArPIKfyve
- Chromosome:
- 16q22.1-q22.2
- Locus Type:
- gene with protein product
- Date approved:
- 2005-02-09
- Date modifiied:
- 2019-04-15
Related products to: VAC14 antibody
Related articles to: VAC14 antibody
- The high prevalence of cancer immunotherapy resistance, coupled with substantial tumor heterogeneity, underscores the urgent need for innovative therapeutic targets. A deeper understanding of immunoregulatory mechanisms would provide new targets and combination therapeutic strategies for tumor therapy. In this study, we demonstrate that HSD17B12 enhances anti-tumor immunity and represents a promising therapeutic target. Mechanistically, HSD17B12 promotes lysosome-dependent degradation of PD-L1 via the VAC14 and ESCRT complexes across various malignancies, regardless of its 3-ketoacyl-CoA reductase activity. HSD17B12-deficient cells displayed PD-L1 accumulation in both tumor cells and exosomes, reducing T cell-mediated cytotoxicity. Notably, we found a significant negative correlation between HSD17B12 and PD-L1 expression in colorectal cancer tissues. Furthermore, high HSD17B12 expression in CRC correlated with increased infiltration of cytotoxic T cells. Based on these findings, we designed a peptide, HSD-CC1-NPGY, which effectively reduces PD-L1 expression in cells and suppresses tumor growth in a mouse model. Overall, our results establish HSD17B12 as an important regulator of anti-tumor immunity and a promising therapeutic target for cancer treatment. - Source: PubMed
Publication date: 2026/01/27
Zhou ZhihuiLu YingLi PanLiu XinCheng WeiChen Hai-NingDai LunzhiRen Haiyan - •Blepharoclonus is defined as a brief clonic contraction of bilateral orbicularis oculi muscles on voluntary eye closure.•NBIA disorders like PKAN, PLAN and Kufor Rakeb disease have shown its association with blepharoclonus.•With this report, can also be added to the phenotype spectrum. - Source: PubMed
Publication date: 2025/08/13
Madhavi KarriKandadai Rukmini MridulaKola SruthiBorgohain RupamPrasad Vvsrk - Lysosomes are essential organelles that regulate cellular homeostasis through complex membrane interactions. Phosphoinositide lipids play critical roles in orchestrating these functions by recruiting specific proteins to organelle membranes. The PIKfyve/Fig4/Vac14 complex regulates PI(3,5)P₂ metabolism, and intriguingly, while loss-of-function mutations cause neurodegeneration, acute PIKfyve inhibition shows therapeutic potential in neurodegenerative disorders. We demonstrate that PIKfyve/Fig4/Vac14 dysfunction triggers a compensatory response where reduced mTORC1 activity leads to ULK1-dependent trafficking of ATG9A and PI4KIIα from the TGN to lysosomes. This increases lysosomal PI(4)P, facilitating cholesterol and phosphatidylserine transport at ER-lysosome contacts to promote membrane repair. Concurrently, elevated lysosomal PI(4)P recruits ORP1L to ER-lysosome-mitochondria three-way contacts, enabling PI(4)P transfer to mitochondria that drives ULK1-dependent fragmentation and increased respiration. These findings reveal a role for PIKfyve/Fig4/Vac14 in coordinating lysosomal repair and mitochondrial homeostasis, offering insights into cellular stress responses. - Source: PubMed
Publication date: 2025/11/28
Kutchukian CandiceCasas MariaDixon Rose EDickson Eamonn J - Exploring novel antifungal mechanisms is needed because of the side effects of existing treatments and the increasing prevalence of drug resistance. We recently reported that inhibition of the endocytic pathway via a lysosome inhibitor or Fab1/Vac14 suppression enhances the localization of emerald green fluorescent protein-bound β-1,3-glucanase (BGL2-EmGFP) at the tip in Saccharomyces cerevisiae INVSc1, used as a non-pathogenic model. Overexpression of wild-type BGL2-EmGFP, but not an inactive mutant, completely abolished cell proliferation, suggesting that impairing tip growth through dysregulated glucanase activity represents a novel antifungal mechanism. In this study, using a phenotypic screening strategy combining fluorescein isothiocyanate (FITC)-dextran endocytosis/exocytosis assays with BGL2-EmGFP localization analysis, Dioscorea tokoro Makino extract was found to induce dysregulation of the endocytic pathway and promote BGL2-EmGFP localization at the tip, accompanied by growth inhibition in S. cerevisiae INVSc1. These findings suggest that this phenotypic screening strategy provides a promising approach based on a novel antifungal mechanism involving endocytic dysregulation and enhanced BGL2 localization at the tip. - Source: PubMed
Publication date: 2025/11/05
Takeshita SenInoue HidekiIida Yasuhiro - - Source: PubMed
Publication date: 2025/09/01
Lindsay RebeccaYoganathan SangeethaLim Wei KangKrishnan PradeepDoja AsifVenkateswaran SunitaRicher JulieBreitbart SaraLiang Nicole S YFasano AlfonsoIbrahim George MGorodetsky Carolina