Ask about this productRelated genes to: UPK2 antibody
- Gene:
- UPK2 NIH gene
- Name:
- uroplakin 2
- Previous symbol:
- -
- Synonyms:
- UP2, UPII, MGC138598
- Chromosome:
- 11q23
- Locus Type:
- gene with protein product
- Date approved:
- 1992-07-31
- Date modifiied:
- 2014-11-19
Related products to: UPK2 antibody
Related articles to: UPK2 antibody
- Non-fibrillar type XVII collagen (COL17A1) is a hemidesmosomal component of the epidermis and a key skin-disease molecule. We previously reported that COL17A1 is expressed in the urothelium of multiple species at low constitutive or in inducible levels. To clarify its function in the ureter, Col17a1-knockout (KO) mice were examined from 2 to 12 weeks of age. After 4 weeks, Col17a1-KO mice showed shorter ureteral length, smaller cross-sectional area, and disorganized urothelial layers compared with wild-type littermates, accompanied by systemic growth retardation. At 4 and/or 12 weeks, Col17a1-KO urothelium exhibited a higher epithelial area ratio, loss of polarity, intraluminal cells, lumen narrowing, and indistinct mucosal folds. Abnormalities were evident as early as 2 weeks, particularly in umbrella cells, which showed altered apical surfaces, hypertrophy, smaller vesicles, and shortened interdigitations. RNA-seq of 2-week-old Col17a1-KO ureters revealed upregulation of immune-related genes and downregulation of epithelial development genes. Uroplakin 2, a key urothelial molecule, was reduced in Col17a1-KO ureters at 1 day and 2 weeks but not at 12 weeks. Its transcription factor, forkhead box protein A1, was persistently reduced, with markedly lower protein expression in umbrella cells. These findings indicate that urothelial COL17A1 is essential for proper urothelial differentiation during postnatal development. - Source: PubMed
Publication date: 2026/04/27
Suzui AmyNamba TakashiHiraishi MasayaOe SaoKira ShunnosukeOtani YukiZhong RuiNatsuga KenIchii Osamu - Chronic radiation cystitis (CRC) is a disabling late adverse effect of pelvic irradiation, characterized by urothelial barrier loss, persistent inflammation, vascular alteration, and progressive fibrosis. No curative treatment exists. Mesenchymal stromal cells (MSCs) are investigated for their regenerative potential, however their long-term mechanisms of action in CRC remain incompletely elucidated. - Source: PubMed
Publication date: 2026/04/19
Pouliet Anne-LaureCôme JadeFail AurélieDos Santos MorganeLinard ChristineDemarquay ChristelleFleury CarlaBuard ValérieBrossard ClémentMilliat FabienChapel Alain - This study aimed to evaluate tissue-associated circulating cell-free DNA (cfDNA) as indicators of radiotherapy-related effects and treatment-associated toxicity in prostate cancer. In addition, inter-individual variability in these markers and their responses to radiotherapy-induced cystitis and rectitis were investigated. The DNA methylation status of six tissue-associated genes representing the prostate (,), colon (,), and bladder (,) was analyzed in serum-derived cfDNA using methylation-sensitive melting curve analysis (MS-MCA). Five of the six analyzed genes demonstrated significantly higher relative DNA levels in patients with prostate cancer compared with controls. Radiotherapy did not significantly alter the relative DNA levels of these tissue-associated genes. However, cfDNA fragmentation was significantly increased in the post-treatment group compared to the pre-treatment group. Notably, 79-bp DNA fragments were significantly more abundant than 230-bp fragments. In the post-treatment group, no significant correlations were observed between cfDNA fragmentation and the relative DNA levels of most targets, except for an association between the 230-bp fragment and relative DNA levels. These findings suggest limited coupling between cfDNA fragmentation patterns and tissue-associated cfDNA release. Marked inter-individual variability in cfDNA methylation signatures was observed across all examined CpG-containing regions except . This variability did not change significantly following radiotherapy and may therefore limit the utility of these assay regions for monitoring individual radiation-induced tissue damage. Furthermore, no significant changes in methylation profiles of colon- or bladder-associated genes were detected in patients who developed radiotherapy-induced rectitis or cystitis. Overall, increased cfDNA fragmentation following radiotherapy and substantial inter-individual variability in methylation profiles across tissue-associated regions may mask tissue-associated cfDNA signals, thereby complicating the assessment of radiation-induced tissue damage. - Source: PubMed
Publication date: 2026/03/06
Bahtiyar NurtenMermut OzlemFirtina SinemOzaydin AhmetSuleymanova AishaIsikgil BegumOnaran İlhan - Ileal substitution is the mainstream treatment for long-segment ureteral defects (LSUDs) but is complicated by the ileum's wide lumen and mucus secretion. This study investigated the long-term efficacy of a modified technique using tapered demucosalized ileum (TDI) in a canine model, with a specific focus on the type and origin of the regenerated epithelium. - Source: PubMed
Publication date: 2026/01/28
Chen ShulianTang WenXie HuihuiLiang PinyaoHan NiweiLuo HuijiuLuo KebingShi FeiLiu MingwenXie ZhifeiLi YiShen LeiZhu HanAi XiaoyuWu TaoLiang GuobiaoZhao Zeju - Uroplakin-2 (UPK2) is a relatively specific marker for urothelial cancer, often used in the differential diagnosis of tumors of unknown origin. UPK2 expression has been observed in colorectal cancers (CRCs), prompting further investigation. - Source: PubMed
Publication date: 2025/12/11
Äijälä Ville KHärkönen JouniSirniö PäiviMantere TuomoElomaa HannaSirkiä OnniKehusmaa AkseliKarjalainen HennaKastinen MeeriTapiainen Vilja VAhtiainen MaaritHelminen OlliWirta Erkki-VilleRintala JukkaMeriläinen SannaSaarnio JuhaRautio TeroSeppälä Toni TBöhm JanMecklin Jukka-PekkaTuomisto AnneMäkinen Markus JVäyrynen Juha P