Ask about this productRelated genes to: UBL4B antibody
- Gene:
- UBL4B NIH gene
- Name:
- ubiquitin like 4B
- Previous symbol:
- -
- Synonyms:
- FLJ25690
- Chromosome:
- 1p13.3
- Locus Type:
- gene with protein product
- Date approved:
- 2005-09-27
- Date modifiied:
- 2015-12-01
Related products to: UBL4B antibody
Related articles to: UBL4B antibody
- : Colonic diverticulosis is a common condition, particularly in the elderly population. While dietary habits, obesity, smoking, and physical inactivity contribute to its pathogenesis, emerging evidence highlights a genetic predisposition affecting extracellular matrix (ECM) remodeling, inflammation, and connective tissue integrity. The aim of this systematic review was to summarize genetic determinants of colonic diverticulosis. : The PubMed database was searched for original studies in humans. The inclusion criteria were named genetic factor and confirmed diverticulosis. Patients with diverticulitis and diverticular diseases were excluded from this review. : Out of 137 publications, 10 articles met the inclusion criteria: six large association studies (GWAS) and four cross-sectional studies. The genes regulating ECM turnover, including , , and , are involved in diverticulosis development. The () T allele has been associated with increased susceptibility, potentially due to its role in ECM remodeling. Similarly, () and () polymorphisms contribute to altered collagen degradation. The () variant coding modified collagen type III may promote diverticular formation. Other genes, such as (, ), affect cytoskeletal dynamics. Identified in GWAS studies, gene candidates may be grouped into blood group and immune system-related genes (, , , , , ), extracellular matrix and connective tissue genes (, , , , , ), signaling and cell communication (, , , , ), nervous system and neurodevelopment (, , , , , ), metabolism and transporters (, , , , ), lipids and cholesterol (, , ), transcription and gene regulation (, , ), apoptosis (, ), and poorly characterized genes (, , , , , , , , , , ). : There are a number of gene variants that probably predispose to colonic diverticulosis. Detailed characterization of the multigene background of diverticulosis will enable appropriate therapeutic or preventive interventions in the future. - Source: PubMed
Publication date: 2025/05/15
Nehring PiotrPrzybyłkowski Adam - The maelstrom spermatogenic transposon silencer (MAEL) function in postmeiotic germ cells remains unclear, and its protein localization in human testis and spermatozoa awaits determination. This study aims to clarify the MAEL expression in human spermatogenesis and to explore its role in sperm function. - Source: PubMed
Publication date: 2023/02/23
Cheng Yu-ShengChen Hsing-YiLin Yu-ChiaoLin Yi-SyuanYeh Yi-ChunYeh Yi-HsuanCheng Yung-HsuanLin Yung-MingWeng Han-YuLin Tsung-YenLin Shih-Chieh - X-derived retrogenes contribute to genetic diversity in evolution and are usually specifically expressed in testis and perform important functions during spermatogenesis. is an autosomal retrogene with testis-specific expression derived from , an X-linked housekeeping gene. In the current study, we performed phylogenetic analysis and revealed that and are subject to purifying selection and may have conserved functions in evolution. was knocked out in mice using CRISPR/Cas9 genome editing technology and interestingly, we found no alterations in reproductive parameters of male mice. To get insights into whether could compensate the absence of , we further obtained mice that lack both and , and the double knockout (dKO) mice also displayed normal spermatogenesis, showing that and are both dispensable for spermatogenesis. Thus, through the study of UBL4A and UBL4B, we provided a direct evidence for the first time that some X chromosome-derived autosomal retrogenes can be unfunctional in spermatogenesis, which represents an additional evolutionary type of X-derived retrogenes. - Source: PubMed
Publication date: 2021/06/25
Yu ChangpingDiao RunjieKhan RanjhaDeng ChengMa HuiChang ZhijieJiang XiaohuaShi Qinghua - Parkinson disease (PD) is one of the most frequent neurodegenerative disorders. The aim of this study was to identify blood biomarkers capable to discriminate PD patients with different progression rates. Differentially expressed genes (DEGs) were acquired by comparing the expression profiles of PD patients with rapid and slow progression rates, using an expression dataset from Gene Expression Omnibus (GEO) under accession code of GSE80599. Altered biological processes and pathways were revealed by functional annotation. Potential biomarkers of PD were identified by protein-protein interaction (PPI) network analysis. Critical transcription factors (TFs) and miRNAs regulating DEGs were predicted by TF analysis and miRNA analysis. A total of 225 DEGs were identified between PD patients with rapid and slow progression profiles. These genes were significantly enriched in biological processes and pathways related to fatty acid metabolism. Among these DEGs, ZFAND4, SRMS, UBL4B, PVALB, DIRAS1, PDP2, LRCH1, and MYL4 were potential progression rate associated biomarkers of PD. Additionally, these DEGs may be regulated by miRNAs of the miR-30 family and TFs STAT1 and GRHL3. Our results may contribute to our understanding of the molecular mechanisms underlying different PD progression profiles. - Source: PubMed
Publication date: 2018/06/23
Fan YanxiaXiao Shuping - GdX (also named Ubl4A) is a house-keeping gene located on the X chromosome and encodes a protein harboring an ubiquitin-like domain in human and mouse. Although identified in 1988, the function of GdX remains unknown. To elucidate the role of GdX in vivo, we generated a conditional GdX knockout mouse in which Exon 2 was flanked by two loxP sites. We obtained viable and fertile mice with homozygous GdX(flox/flox) or GdX(flox/Y) allele. Germ-line transmission was confirmed by crossing the mouse bearing conditionally targeted allele with an EIIα-Cre transgenic mouse. GdX was successfully depleted in tissues of EIIα-Cre-GdX-null mice. GdX(-/-) and GdX(-/Y) mice are viable and exhibit normal development compared with wild-type littermates within 6 months during our observation. We also observed that GdX knockout male mice were functionally normal in the reproductive system where Ubl4B was specifically expressed. GdX(flox/flox) and GdX(flox/Y) conditional mice provide a tool for further tissue-specific function analysis of the GdX protein under different conditions. - Source: PubMed
Publication date: 2012/01/24
Wang YangmengWang DianjunRen FangliZhang YuanjiangLin FuyuHou NingCheng XuanZhang PengWang YinyinJia BaoqingYang XiaoChang Zhijie