Ask about this productRelated genes to: TNS3 antibody
- Gene:
- TNS3 NIH gene
- Name:
- tensin 3
- Previous symbol:
- TENS1
- Synonyms:
- TEM6, H_NH0549I23.2, FLJ13732
- Chromosome:
- 7p12.3
- Locus Type:
- gene with protein product
- Date approved:
- 2003-08-27
- Date modifiied:
- 2014-11-19
Related products to: TNS3 antibody
Related articles to: TNS3 antibody
- Fibrosis is a severe pathological outcome of many chronic diseases, yet the therapeutic potential of targeting the altered major histocompatibility complex (MHC) class I immunopeptidome remains largely unexplored. Here we characterized the MHC class I immunopeptidomes from both fibrotic foci of human idiopathic pulmonary fibrosis lung explants and bleomycin-treated mice, identifying a diverse repertoire of fibrosis-associated peptides. Parallel profiling of bleomycin-induced pulmonary fibrosis in mice enabled the computational prioritization of therapeutic targets. In vivo, therapeutic vaccination with three candidate peptides (MAF, APBB2 and TNS3) effectively mitigated fibrosis progression in bleomycin-treated mice. Furthermore, leveraging its evolutionary conservation, we found that MAF elicited specific human cytotoxic T lymphocytes that lysed human idiopathic pulmonary fibrosis-derived myofibroblasts and M2-like macrophages. This study indicates that immunopeptidome profiling provides a robust platform for discovering translatable antifibrotic immunotherapies. - Source: PubMed
Publication date: 2026/04/20
Bai ZiyiLan TianxiaHong WeiqiQue HaiyingZhu MinXiao XinWan DandanAi JiayuanHuang ShaoxiongWang JiayuHong QiaonanLiu YanyanXiao ChengxinZhao ChengjianWang XinZhang XiaolongYang TingXu HengDai LunzhiPowell Charles ARicheldi LucaLuo FengmingDong HaohaoYuan YongPu QiangWei Xiawei - Tensins are a family of adhesion proteins that play a role in constructing the cytoskeleton, as well as in intracellular and extracellular communication. Their expression was evaluated in 22 pancreatic cancer patients using the immunohistochemistry method. TNS1 expression occurred more frequently among patients with tumor diameter ≥ 2 cm, which may suggest an association with the development of pancreatic cancer. Intraductal TNS1 was observed less often with presence of necrosis and hemorrhages in tumor. The fact that cancer cells secrete TNS1 suggests that it could be investigated as a potential target for liquid biopsies. TNS4 expression occurred more frequently among females and was observed when necrosis in tumor was strong. TNS2 and TNS3 are not involved in the development of ductal pancreatic adenocarcinoma. - Source: PubMed
Publication date: 2026/04/01
Świsłocka NataliaPryczynicz AnnaDorf JustynaZaręba KonradGuzińska-Ustymowicz Katarzyna - Recent findings emphasize that IRF1 and IRF2 play distinct roles in gene regulation, particularly through chromatin remodeling during antiviral responses. Our current data extend this by revealing that IRF1 directly targets TNS3, a key regulator of renal stress, fibrosis, and the aging process. We identify a mechanistic parallel between the IRF1-TLR3 and IRF1-TNS3 pathways, proposing that targeting the IRF1-mediated modulation of TNS3 could offer a fresh therapeutic approach for kidney injury. - Source: PubMed
Publication date: 2026/03/19
Huang Chien-WeiWen Chen-YuehHsu Yu-JueiLi Chia-Jung - Sheep have diversified into distinct breeds worldwide through both natural adaptation and human-driven selection, with hybridization serving as an effective strategy for rapid trait improvement. The Tianhua mutton sheep (TMS) is a novel breed derived from crossing South African Mutton Merino (SAMM) with Gansu alpine fine-wool sheep (GAFS). After nearly two decades of selective breeding, TMS has developed great meat quality traits and impressive cold tolerance at high altitudes. To study the genetic mechanism and provide new insights into phenotypic variation, we analyzed the genetic diversity, population structure, and selective signatures of TMS based on whole-genome sequencing of 55 TMS, 11 SAMM, and 197 public sheep genomes worldwide. - Source: PubMed
Publication date: 2026/01/31
Jiang BeixiangZeng JizeChi HuanpengShan JingfangZhang XueyingFeng QianjieLi FadiYue XiangpengFu Weiwei - *4 is the strongest, common genetic risk factor for late-onset Alzheimer's disease (AD) with widespread and cell-type-specific impact on disease pathogenesis. Genetics and omics studies can help identify genes that counteract the effects of *4, but so far have remained relatively small and crucially did not assess genetic findings through a cell-type-specific framework. - Source: PubMed
Publication date: 2025/12/04
Zeng YoujieCook NoahYang ChenyuSivasankaran Sathesh KFujita MasashiGardell Zachary ALe Guen YannShigemizu DaichiOzaki KouichiMorizono TakashiHara NorikazuMiyashita AkinoriIkeuchi TakeshiPottier CyrilCruchaga CarlosNapolioni ValerioCorces M RyanMenon VilasGreicius Michael DBelloy Michael E