Ask about this productRelated genes to: TNNI2 antibody
- Gene:
- TNNI2 NIH gene
- Name:
- troponin I2, fast skeletal type
- Previous symbol:
- AMCD2B
- Synonyms:
- FSSV, DA2B
- Chromosome:
- 11p15.5
- Locus Type:
- gene with protein product
- Date approved:
- 1989-12-11
- Date modifiied:
- 2019-04-23
Related products to: TNNI2 antibody
Related articles to: TNNI2 antibody
- Postpartum stress urinary incontinence (SUI) significantly impacts women's quality of life, yet the underlying molecular mechanisms of effective treatments remain elusive. This study aimed to investigate the therapeutic effects and molecular pathways of electroacupuncture (EA) in a rat model of SUI. We established the SUI model using vaginal balloon dilation (VBD) and randomized subjects into model and EA-treated groups. Functional recovery was assessed by urodynamic testing, which showed that EA significantly increased leak point pressure (LPP) and maximum bladder capacity (MBC). Histopathological analysis using hematoxylin and eosin and Masson's trichrome staining revealed improved muscle architecture and a 42.3% reduction in collagen deposition, along with suppressed inflammatory responses. Quantitative proteomics identified 2,907 differentially expressed proteins (DEPs), with the STRING database highlighting motor protein pathways as central targets. Specifically, EA selectively downregulated core proteins, including MYL1, TNNI2, MYLPF, TNNT3, and TNNT1. These findings, validated by western blot and qPCR, suggest that EA alleviates SUI by modulating muscle contractility and remodeling the pelvic floor, providing insight into potential mechanisms underlying targeted SUI therapy. - Source: PubMed
Publication date: 2026/04/07
Jiang XiaoyuLiang HuilingSheng WeiweiSun Jian - This study aimed to compare the anatomical characteristics of embryonic chicken muscle satellite cells (CMSCs) derived from breast and leg muscles of 18-day-old embryos. We analyzed the cellular behaviors related to proliferation, metabolism, and differentiation capacity. Breast-derived CMSCs exhibited significantly higher proliferation rates and accelerated cell cycle progression, as evidenced by a higher S phase distribution and lower G2/M phase distribution compared to leg-derived CMSCs. In addition, immunofluorescence staining for myogenic regulatory factors revealed that breast-derived CMSCs exhibited higher expression levels of paired box protein 7 (PAX7), consistent with elevated PAX7 and myogenic differentiation 1 (MYOD) mRNA expression compared with leg-derived CMSCs. In contrast, leg-derived CMSCs showed significantly higher expression of myogenin (MYOG). Moreover, leg-derived CMSCs exhibited significantly higher mitochondrial respiratory activity indices, including oxygen consumption rate and basal respiration. In differentiation capacity analysis, the leg-derived CMSCs formed structurally more developed myotubes, and the expression of muscle-specific genes (MYOD, MYOG, MYH1E, MYH7, TNNI1, TNNI2) was also significantly higher. These findings suggest that breast-derived CMSCs exhibit superior proliferative capacity, while leg-derived CMSCs possess enhanced myogenic differentiation potential, as supported by their increased oxidative phosphorylation activity and elevated expression of differentiation-related markers. In conclusion, the anatomical origin of CMSCs significantly influences their proliferative and differentiation capacities as well as their metabolic properties, providing a valuable basis for selecting optimal cell sources for cultured meat production and meat quality improvement. - Source: PubMed
Publication date: 2026/03/17
Kim JongryunLee JeongeunYu DongjinKim LeecheonKang DaraePark JinryongSong GuybongLee HakkyoShim Kwanseob - Xizang sheep are vital economic livestock in plateau regions. Traditional surgical castration often induces stress and infection. Although immunization presents an alternative method, the physiological mechanisms underlying its effects in Xizang sheep remain unclear. Therefore, this study integrated serum immune-antioxidant indicators with hypothalamus-pituitary transcriptomics to investigate molecular mechanisms of GnRH immunization. Results indicated that serum IgA, IgG, IgM, SOD, and GSH in the immunization (IM) group were significantly higher than in control (CON) and surgical castration (SN) groups, while IL-6 and TNF-α were significantly reduced ( < 0.05). RNA-seq analysis revealed that hypothalamic , , , , and were significantly upregulated in IM group, whereas and were significantly downregulated, with notable enrichment in prion disease, oxidative phosphorylation, and thermogenesis pathways. Pituitary was upregulated while , , , , and were significantly downregulated, showing enrichment in myofibril, contractile fiber, sarcomere, and cytosolic ribosome pathways. Association analysis revealed significant positive correlations between IgG and pituitary , , , as well as hypothalamic , , and . In summary, GnRH immunization outperforms surgical castration by modulating hypothalamic-pituitary genes and enhancing immunity and antioxidants in plateau Xizang sheep, achieving integrated neuroendocrine-immune regulation for healthy husbandry of plateau Xizang sheep. - Source: PubMed
Publication date: 2026/02/19
Song TianzengMustafa Shehr BanoLi HaiyanZhang XiaomingWang GaofuZhang TingtingChen XiaoyingCui JianzhaoZhang MingZeng XianyinLiu GuiqiongXian LiliJiayang ZhuomaZhao WangshengJiang Xunping - This study applied shotgun proteomics to investigate the temporal changes in goat meat exudate and elucidate the biochemical mechanisms underlying postmortem aging. Exudates were collected from vacuum packaged goat Longissimus thoracis muscles at 24, 48 and 72 h postmortem. A total of 823 proteins were identified and quantified, of which 188 were differentially abundant: n = 60 between 24 h vs. 48 h, n = 56 between 48 h vs. 72 h and n = 168 between 24 h vs. 72 h. Comparative analyses revealed distinct temporal release patterns, with catalytic and ATP-metabolic proteins predominating early postmortem (17%), structural and contraction-related proteins peaking between 48 h and 72 h (39%), and binding, transport, and calcium homeostasis proteins (27%), as well as extracellular matrix (ECM) and matrisome components (14%), accumulating later. Chaperones including heat shock proteins and proteolytic and related enzymes were consistently released from 24 h to 72 h, but in lower percentages (5% and 4%, respectively). Overlap analysis identified 14 core proteins including FLNC, TNNI2, TNNC2, PDLIM7, TMOD4, MYOZ1, MYBPC1, MYOM2 (muscle contraction and structure), DYSF, EIF4G2, PPARGC1A (binding, transport and calcium homeostasis), DCN, OGN, and IGFALS (matrisome and ECM associated proteins), shared across all time points, which mapped to five significantly enriched pathways, primarily myofibril assembly and muscle system processes. These findings provide the first comprehensive proteomic profile of goat meat exudate, demonstrating its potential as a non-invasive source for monitoring postmortem biochemical changes and meat tenderization dynamics, ultimately offering insights to improve meat quality. - Source: PubMed
Publication date: 2026/01/22
Gagaoua MohammedAlbenzio MarziaDella Malva Antonella - The longissimus dorsi muscle and backfat are important components of pork and complement each other in physiological function, significantly influencing key traits such as growth performance, carcass traits, and meat quality. While the transcriptomic atlas across different tissues in pigs has been widely studied, the underlying epigenetic regulatory mechanisms remain to be explored. In this study, we collected muscle and adipose tissues from hybrid offspring of lean-type (Western commercial pigs) and fat-type (Chinese indigenous pigs) pigs ( = 6) and performed integrated transcriptomic (RNA-seq) and DNA methylome (GM-seq) analysis to explore how DNA methylation coordinates tissue-specific differential gene expression. This has practical implications for optimizing breeding strategies and selecting superior breeds. - Source: PubMed
Publication date: 2026/01/24
Ge MeiLi ChenyuJiang TaoHuang YaniZhang Zhiyan