Ask about this productRelated genes to: TNFSF14 antibody
- Gene:
- TNFSF14 NIH gene
- Name:
- TNF superfamily member 14
- Previous symbol:
- -
- Synonyms:
- LIGHT, LTg, HVEM-L, CD258
- Chromosome:
- 19p13.3
- Locus Type:
- gene with protein product
- Date approved:
- 1998-12-04
- Date modifiied:
- 2017-03-02
Related products to: TNFSF14 antibody
Related articles to: TNFSF14 antibody
- Two biological subphenotypes in acute respiratory distress syndrome (ARDS) have been identified in retrospective analyses, with differential clinical outcomes and post-hoc responses to investigational treatments. The ability to identify biological subphenotypes in real-time is unknown. We aimed to evaluate the feasibility of using the multisite ISPY COVID Network to prospectively evaluate biological subphenotypes in real-time. - Source: PubMed
Publication date: 2026/05/15
Files D ClarkMatthay Michael AChapple Andrew GBarragan Alejandro BotelloMabrey LinzeeGibbs Kevin WKrall JenniferAggarwal Neil RBurnham Ellen LLiu Kathleen DMeyer Nuala JNates Joseph LYoussef Fady AFriedman EliotKett Daniel HKoff JonathanRussell Derek WCalfee Carolyn SEklund MartinEsserman Laura J - People with type 1 diabetes feature lower concentrations of hepatic adenosine-triphosphate (ATP) and inorganic phosphate (Pi), which further decline during the early course of disease. However, it is unknown whether inflammatory pathways are involved in the diabetes-associated alterations of hepatic energy metabolism. Participants (median age 35 years, BMI 21.7 kg/m, HbA1c 6.0%) of the German Diabetes Study (GDS) with short type 1 diabetes duration (≤ 5 years) underwent H/P magnetic resonance spectroscopy to quantify hepatic lipid content, γATP and Pi concentrations. Inflammatory proteins in serum and in supernatants of stimulated CD4 and CD8 T cells were measured by a multiplex assay (OLINK Target 96 Inflammation). Analyses were adjusted for multiple testing with false discovery rate (FDR)-correction. Hepatic γATP concentrations positively correlated with circulating TNFSF14 (r = 0.98, p < 0.001, p = 0.009) and MMP10 (r = 0.71, p = 0.047). Hepatic Pi was positively associated with circulating MMP10 (r = 0.90, p = 0.002), with CD4 T cell responses, particularly CCL3 (r = 0.74, p = 0.010) and CCL4 (r = 0.75, p = 0.008), and with CD8 T cell responses, particularly CCL3 (r = 0.86, p = 0.014), CCL4 (r = 0.96, p < 0.001) and TNFSF14 (r = 0.89, p = 0.007). Hepatic lipid content (median 0.4%) negatively correlated with IL-2, IL4, IL-13 and TNF release from CD8 T cells (all p < 0.05). Even in lean metabolically well-controlled persons with early type 1 diabetes, measures of hepatic energy metabolism strongly associate with a specific inflammatory profile and T cell responses, suggesting a role of pro-inflammatory mechanisms in the regulation of hepatic metabolism, even in the absence of steatotic liver disease. Trial Registration: ClinicalTrial.gov identifier: NCT01055093. - Source: PubMed
Ratter-Rieck Jacqueline MZepina AlexandraHuttasch MaximilianKupriyanova YuliyaPetrera AgneseTrenkamp SandraWagner RobertSchrauwen-Hinderling VeraHerder ChristianRoden Michael - Osteochondral defects present substantial clinical challenges due to the complex, multilayered structure and distinct physiological properties of cartilage and subchondral bone. Here, we report a three-dimensional (3D)-printed osteochondral scaffold featuring a dual biomimetic design that integrates vertically oriented microchannels with bioinspired nano-mineral precursors. Specifically, a multifunctional hierarchical construct was developed by incorporating ultrasmall (∼1 nm) polymer-induced liquid precursor-modified amorphous calcium phosphate (nCaP) into a GelMA-based matrix. Using digital light processing-based 3D printing, a biphasic scaffold with spatially defined architectures was fabricated, consisting of a pure GelMA upper layer featuring combined lotus-like and radial pore distributions to emulate the cartilage microenvironment, and a nCaP/GelMA lower layer with lotus-like pore architecture to support subchondral bone regeneration. Notably, in contrast to conventional inorganic fillers such as nanohydroxyapatite (nHAp), the incorporation of ultrasmall nCaP nanoclusters did not adversely affect photopolymerization behavior or printing fidelity, thereby enabling high-resolution fabrication. Beyond structural advantages, nCaP incorporation markedly enhanced the bioactivity of the scaffold. Compared with nHAp, nCaP significantly promoted the recruitment and osteogenic differentiation of endogenous bone marrow-derived mesenchymal stem cells, while also facilitating extracellular matrix deposition, mineralization, and angiogenesis. Transcriptomic analysis further indicated that these effects were associated with the upregulation of angiogenic factor EGFL6, suppression of inflammation-related TNFSF14/NF-B signaling, and activation of the PI3K-Akt pathway. Collectively, bothandevaluations demonstrated that the nCaP/GelMA scaffold achieved improved tissue integration, restoration of hierarchical architecture, and enhanced mechanical performance compared with control groups. These findings underscore the potential of dual biomimetic scaffold design as an effective strategy for osteochondral regeneration. - Source: PubMed
Publication date: 2026/05/08
Jiang QiWu YicongDing ZiyuHuang BoweiGu YuqingZhang XianzhuHuang YuxuanOuyang HongweiZhang Shufang - Chronic kidney disease (CKD) is a global public health burden characterized by irreversible renal function loss and progressive fibrosis. Non-invasive biomarkers reflecting intra-renal inflammation and early tubulointerstitial injury remain an unmet clinical need. We combined bioinformatics analysis with clinical validation to characterize two immune-related genes, TNFSF14 and CD40, in CKD progression. - Source: PubMed
Publication date: 2026/04/25
Gu XiamengLu YuqingSha HaonanZhang HanluChen HongxinQiu MengyueChen Xiaolan - Tumor necrosis factor superfamily 14 (TNFSF14) has been implicated in the pathogenesis of cardiovascular disease, including atrial fibrillation (AF). However, its role in predicting AF recurrence after catheter ablation (CA) remains unexplored. - Source: PubMed
Zhou DongtaoLiu FangLiu TongLi MengmengJiang ChenxiTang RiboWang WeiZhao XinLi ChangyiJia ChangqiNing ManFeng LiWen DanLin JingZhu HuiJiang YuexinGuo XueyuanLi SongnanJiang ChaoZhou NingSang CaihuaLong DeyongDu XinDong JianzengMa Changsheng