Ask about this productRelated genes to: TNFRSF4 antibody
- Gene:
- TNFRSF4 NIH gene
- Name:
- TNF receptor superfamily member 4
- Previous symbol:
- TXGP1L
- Synonyms:
- ACT35, OX40, CD134
- Chromosome:
- 1p36.33
- Locus Type:
- gene with protein product
- Date approved:
- 1994-12-15
- Date modifiied:
- 2019-04-23
Related products to: TNFRSF4 antibody
Related articles to: TNFRSF4 antibody
- The tumor microenvironment, particularly the tumor stroma, plays a critical role in tumor progression, immune evasion, and therapeutic resistance. However, its interaction with the immune landscape in rectal cancer (RC) remains incompletely understood. This study aimed to comprehensively characterize the stromal-immune ecosystem associated with the tumor stroma ratio (TSR) in RC and to evaluate its clinical and therapeutic relevance. - Source: PubMed
Publication date: 2026/08/03
Wang QianyuTian NaGuo HanchuanXiang YingshiXiao YiLin GuoleZhang GuannanXu LaiLu JunyangChen GangCai HuiyunDu XiaohuiDu JunfengWu Bin - : Laryngeal squamous cell carcinoma (LSCC) is a highly aggressive malignancy with poor prognosis, particularly in advanced stages. While traditional treatments have improved survival rates, reliable biomarkers for prognosis remain limited. : We analyzed RNA-seq data of LSCC patients from the Cancer Genome Atlas (TCGA) and validated the results using the Gene Expression Omnibus (GEO) dataset (GSE27020), clinical samples, and LSCC cell lines. Differentially expressed immune-related genes (DEIRGs) were identified using the "limma" R package. A prognostic signature was developed by integrating univariate Cox analysis, least absolute shrinkage and selection operator (LASSO) regression, and multivariate Cox analysis. The signature's predictive performance was validated using Kaplan-Meier survival analysis and receiver operating characteristic (ROC) curves. : A three-gene immune-related prognostic signature comprising TNFRSF4, PPARG, and PDGFA was established. In the training cohort, the model stratified patients into high- and low-risk groups with significantly different overall survival (HR = 5.81, 95% CI: 2.56-13.22, < 0.001), with apparent 1-, 2-, and 3-year AUC values of 0.838, 0.895, and 0.947, respectively. Predictive performance was further evaluated in the TCGA testing cohort, the full TCGA cohort, and the GSE27020 cohort. Functional enrichment analysis revealed that the signature genes are involved in immune regulation and tumor progression. : This study identified and validated a novel three-gene immune-related prognostic signature for LSCC, offering a practical tool for individualized prognosis and personalized treatment strategies. The signature provides insights into immune-related mechanisms in LSCC, presenting potential targets for therapeutic intervention. - Source: PubMed
Publication date: 2026/07/09
He ChangdingPeng WanqiuShi YiDu Huaidong - Hepatocellular carcinoma (HCC) is a highly malignant and aggressive tumor. Immune-related genes (IRGs) expression correlates closely with the HCC immune microenvironment, and this study aims to identify immune-related diagnostic markers in HCC. - Source: PubMed
Publication date: 2026/04/30
Li WeiJiang HangDuan JianHe JinlanZhao LipingZhong GuopingFan Chenghu - Lung Squamous Cell Carcinoma (LUSC), a common subtype of non-small cell lung cancer, primarily occurs in elderly individuals and is closely linked to senescence-related biological processes. Meanwhile, senescence reshapes the tumor microenvironment by promoting immune suppression and angiogenesis, and its underlying mechanisms remain unclear. Here, we identified three senescence-related molecular subtypes of LUSC, each with distinct clinical outcomes, genomic alterations, and immune features. Among them, Cluster 1 was associated with poor prognosis, increased genomic instability, and an immunosuppressive TME enriched with senescence signatures. To uncover the underlying mechanisms, we integrated bulk and single-cell transcriptomic data and found extensive senescence reprogramming across epithelial, myeloid, and T/NK cell compartments. Notably, senescent immune subsets-such as S100A9 + macrophages and TNFRSF4 + Tregs-were markedly enriched in older patients. Furthermore, cell communication analysis revealed enhanced intercellular signaling in senescent cells. Based on these findings, we constructed a robust machine learning-based prognostic model incorporating senescent gene expression and cell-type abundance to predict survival and immunotherapy response. Finally, functional validation demonstrated that UGT1A7 acts as a pro-proliferative driver that is significantly downregulated during the induction of cellular senescence. Experimental depletion of UGT1A7 phenocopies this senescence-associated decline, thereby triggering growth arrest and inhibiting tumor progression, suggesting its potential as a therapeutic target. Our study reveals how senescence-related alterations in cellular composition and transcriptional dysregulation reshape the tumor microenvironment, providing novel biomarkers and a theoretical basis for therapy. - Source: PubMed
Publication date: 2026/07/08
Mao ShengqiangDeng TongLiu ZhiqiangDing RenxinLi LeiLin Yidan - Recurrent pregnancy loss (RPL) is characterized by two or more consecutive pregnancy losses, often associated with genetic, immunological, endocrine, and anatomical abnormalities. Among these, chromosomal abnormalities, including aneuploidies and submicroscopic copy number variations (CNVs), play a critical role in adverse pregnancy outcomes. A total of 125 fetal specimens were collected, of which 118 were included after applying predefined exclusion criteria. DNA isolated from products of conception and fetal tissues was subjected to quantitative fluorescent PCR (QF-PCR) for rapid aneuploidy screening. A subset of 30 samples with selected QF-PCR outcomes underwent array comparative genomic hybridization (aCGH). Identified CNVs were interpreted according to ACMG/ClinGen guidelines, followed by bioinformatics analyses using FunRich, WebGestalt, KEGG, and STRING to explore functional annotations and pathway enrichment. Among 118 samples, QF-PCR identified aneuploidy in 36 cases (30.5%), including monosomy (n = 20) and trisomy (n = 16), while 82 cases were reported as normal. Maternal age showed a significant association with chromosomal abnormalities (p < 0.05), and a weak negative correlation was observed between gestational age and aneuploidy risk (r = - 0.238, p = 0.008855). In the aCGH cohort (n = 30), clinically relevant CNVs were identified, including pathogenic and likely pathogenic variants, as well as variants of uncertain significance (VOUS). Notably, genes such as CFHR3, TNFRSF4, UGT2B17, CD24, MSR1, and the PSG gene family were implicated. Functional enrichment analysis revealed involvement in immune-inflammatory pathways, endocrine regulation, lipid metabolism, extracellular matrix remodeling, and placental development. This study demonstrates the enhanced diagnostic utility of combining aCGH with QF-PCR for identifying chromosomal abnormalities in RPL. However, the observed associations between CNVs and biological pathways are exploratory in nature and require validation in larger, well-powered cohorts. - Source: PubMed
Publication date: 2026/06/30
Mishra ShivaniAshish AshishRai SangeetaYadav Abhay KumarSingh Royana