Ask about this productRelated genes to: TNFRSF4 antibody
- Gene:
- TNFRSF4 NIH gene
- Name:
- TNF receptor superfamily member 4
- Previous symbol:
- TXGP1L
- Synonyms:
- ACT35, OX40, CD134
- Chromosome:
- 1p36.33
- Locus Type:
- gene with protein product
- Date approved:
- 1994-12-15
- Date modifiied:
- 2019-04-23
Related products to: TNFRSF4 antibody
Related articles to: TNFRSF4 antibody
- OX40 (TNFRSF4) is a costimulatory T-cell receptor and OX40 agonists are in clinical development, yet its role in small cell lung cancer (SCLC) is still to be characterised. We analysed the discovery cohort ( = 77, 48 events), GSE60052 ( = 79 tumours; 48 with survival), GDSC1+GDSC2 (61 SCLC cell lines, 542 drugs) and human SCLC single-cell atlas (77,143 cells from primary and metastatic sites, 20 donors), using Cox models, FDR-controlled correlation, nested-model comparison and deconvolution. High TNFRSF4 showed a non-significant protective trend (pooled HR = 0.86 per SD, 0.68-1.10, = 0.23); a nominal cutpoint did not survive correction for cutpoint search ( = 0.25). No drug reached FDR < 0.05 among 658 tests, including platinum agents and etoposide. TNFRSF4 tracked immune infiltration (13-gene score ρ = 0.76, = 3 × 10) and was detected in 17.6% of T cells versus 1.03% of malignant cells in all 20 donors. OX40 was enriched in the POU2F3/SCLC-P subtype ( = 0.033), persisting after immune adjustment (β = 1.32, = 0.011) but not replicating independently ( = 0.10). Adding TNFRSF4 to clinical-plus-immune models provided no meaningful discrimination gain (ΔC-index ≤ 0.005). Power was limited to HR ≥ 1.50 harmful or HR ≤ 0.67 protective, so the observed trend is undetectable at this size. Bulk OX40 therefore primarily reflects immune infiltration, and its SCLC-P association is a hypothesis for prospective testing. - Source: PubMed
Publication date: 2026/08/31
Özer Mehmet TuranÖzalp Faruk Recep - Regulatory T cells (Tregs) suppress antitumor immunity in ovarian cancer (OC) and are promising targets for immunotherapy. However, the heterogeneity and regulatory mechanisms of tumor-infiltrating Tregs (TI-Tregs) remain poorly defined. Here, we aim to delineate TI-Treg programs to identify potential therapeutic targets. - Source: PubMed
Publication date: 2026/08/12
Wu LeiTao ZiqiZhang YueluMao YepengZhang LeiYan LinaLi RongZhou LingfeiLiu ZhijieShang WenwenLiu ShunaLou JianfangHuang XiWang TingWang Fang - The etiology of coronary artery Disease (CAD) appears different for men and women, yet insights into underlying sex-specific biological mechanisms are limited. We integrated genomic and proteomic analyses to investigate sex-specific associations of the plasma-proteome with CAD. - Source: PubMed
Publication date: 2026/09/03
Sier Vincent QDimitrova KristinaPeters Erna H A Bvan der Loo Wouter P MWillems van Dijk Kovan Heemst DianaBax Wilhelmina HQuax Paul H APasterkamp GerardMokry MichalJukema J WouterNoordam Raymondde Vries Margreet R - Diet is a modifiable determinant of aging. We develop and validate the Machine-learning YouTHful (MYTH) Diet, a dietary pattern associated with reduced aging-related mortality. Using data from 191,689 participants in the UK Biobank, we conducted a food-wide association analysis and identified 18 food groups significantly associated with aging-related mortality. A Light Gradient Boosting Machine (LightGBM) model was used to rank food importance, leading to the construction of a 10-component MYTH Diet score (range: 0-10). Higher MYTH scores were consistently associated with reduced aging-related mortality in both internal (Quartile 4 vs. 1: hazard ratio [HR] = 0.79; 95% CI: 0.75-0.84) and external (Q4 vs. Q1: HR = 0.68; 95% CI: 0.58-0.80) validation cohorts. Multi-omics analyses revealed that the diet's protective effects were partly mediated through proteomic, metabolic, and inflammatory pathways, with mediators including TNFRSF4, the proportion of polyunsaturated fatty acids (PUFA%), and lipid-related metabolites such as medium very-low-density lipoprotein phospholipids (M-VLDL-PL). Higher MYTH scores were also linked to slower biological aging in the lungs, liver, pancreas, as well as lower risks for 15 aging-related diseases. These findings suggest that the MYTH Diet may offer a biologically informed, scalable framework for developing personalized nutrition strategies aimed at supporting healthy aging and longevity. - Source: PubMed
Publication date: 2026/08/07
Miao YatingLi ZhirongZhang XinyaoLiu ZuyunMa Yanan - - Source: PubMed
Publication date: 2026/08/25
Komatsu-Fujii TakayoshiAsahina RyotaHasegawa TatsuyaNakamizo SatoshiNakajima SaekoKogame ToshiakiKabashima Kenji