Ask about this productRelated genes to: TNFAIP6 antibody
- Gene:
- TNFAIP6 NIH gene
- Name:
- TNF alpha induced protein 6
- Previous symbol:
- -
- Synonyms:
- TSG6, TSG-6
- Chromosome:
- 2q23.3
- Locus Type:
- gene with protein product
- Date approved:
- 1992-10-20
- Date modifiied:
- 2015-11-23
Related products to: TNFAIP6 antibody
Related articles to: TNFAIP6 antibody
- Tumor necrosis factor-alpha-induced proteins (TNFAIPs) are key regulators of inflammation, apoptosis, and immune signaling, yet their integrated roles in breast cancer (BC) remain poorly characterized. While individual TNFAIP members have been studied in other cancers, a comprehensive multi-omics characterization of this gene family in BC is still needed. - Source: PubMed
Publication date: 2026/05/29
Barati TaherehMoghaddam Madiheh MazaheriMokhles FatemehMirzaei ZohrehEbrahimi AmirHosseini Golsa Nayeb GhanbarAllahyari Fard Najaf - Rheumatoid arthritis (RA) is a chronic autoimmune disease that can lead to multiple complications. Sjögren's syndrome (SS) is another autoimmune condition that may occur as a primary disorder or in conjunction with other autoimmune diseases, including RA. This study aimed to investigate the shared gene signatures between RA and SS. Gene expression datasets for RA (GSE15573, GSE93776) and SS (GSE48378, GSE94510, GSE93683) were obtained and analyzed to identify differentially expressed genes (DEGs) in peripheral blood mononuclear cells (PBMCs) and T cells. Gene ontology (GO) analysis and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis were performed on the DEGs identified. Quantitative real-time PCR (qRT-PCR) was used to validate the expression levels of DEGs in PBMCs from patients with RA and SS. A total of 244 DEGs were identified from the RA PBMC dataset, comprising 142 upregulated genes and 102 downregulated genes. These DEGs were significantly enriched in biological processes related to immune responses, including cellular response to lipopolysaccharide, defense response against fungi, inflammatory responses, and antibacterial humoral responses. In contrast, 335 DEGs were identified from the SS PBMC dataset; among these, 320 genes were upregulated, while 15 were downregulated. The DEGs associated with SS showed strong involvement in defense responses against viruses, innate immune responses, viral responses, as well as cellular reactions to lipopolysaccharide. Moreover, we identified 12 shared DEGs between RA and SS PBMCs: RNASE2, NDUFB3, LY96, ANKRD22, EIF2AK2, RNASE3, CLEC4D, TNFAIP6, DYNLT1, RPS27L, LILRA5, and F5. Validation through qRT-PCR confirmed increased expression levels of RNASE2, RNASE3, NDUFB3, and EIF2AK2 in PBMCs. This study successfully delineated key DEGs along with their associated biological processes within the context of RA and SS PBMCs. Through bioinformatics analyses combined with qRT-PCR validation, we have identified four critical genes that may serve as potential biomarkers or therapeutic targets for further investigation. - Source: PubMed
Publication date: 2026/04/25
Li Yi-FanGao Zhao-WeiLiu LiWang XiFan KunLin FangHei Ruo-Xuan - To investigate the effect of specifically regulating histone deacetylase 3 (HDAC3) on the in vitro maturation (IVM) of bovine oocytes and to elucidate the underlying molecular mechanisms. During IVM, COCs were treated with luteinizing hormone (LH) or different concentrations of the HDAC3-specific inhibitor HDACi 4b. Treatment with 4 μM HDACi 4b significantly promoted cumulus expansion and up-regulated the expression of expansion-related genes (HAS2, PTX3, and TNFAIP6) in cumulus cells after IVM (P < 0.05). The first polar body extrusion rate, cleavage rate, and blastocyst rate in the 4 μM HDACi 4b group were comparable to those in the LH group, with normal blastocyst quality. ELISA found no significant difference for the concentration of AREG in the culture medium between the 4 μM HDACi 4b and LH groups, but both were significantly higher than the negative control. Further exploration of the underlying mechanisms in primary granulosa cell line revealed that HDACi 4b inhibited the expression of HDAC3 protein in a time-dependent manner and concurrently up-regulating H3K14ac and AREG levels (P < 0.05). While inhibition of the transcription factor SP1 significantly attenuated the HDACi 4b-induced up-regulation of AREG (P < 0.05). The HDAC3-H3K14ac-SP1-AREG signaling pathway plays a critical regulatory role in the maturation of bovine oocytes. Our work profiles a novel and stable strategy for bovine oocyte IVM. - Source: PubMed
Publication date: 2026/05/15
Hu YingfanHeng NuoGuo YaxinWang YiWang HuanHu ZhihuiZhu HuabinWang ChaoShi LeiZhao Shanjiang - Vasculogenic mimicry (VM) plays vital roles in tumor development that are closely relevant to patient adverse outcomes and chemoresistance. This study aimed to identify a novel VM-associated signature to forecast the prognosis and immunotherapy response of head and neck squamous cell carcinoma (HNSC) patients. - Source: PubMed
Publication date: 2026/04/30
Zhai YujiaGu XinyuHuang DiXue Miaomiao - This study aims to investigate the therapeutic potential of umbilical cord-derived mesenchymal stem cells (UCMSCs) for dry eye disease (DED) and elucidate the underlying mechanisms, with particular focus on the role of TSG-6 in modulating the pathogenic Th17/CCL20-CCR6 inflammatory axis. - Source: PubMed
Liang QiChen ZeyingLiu YaoyaoGuo RongjieZhang DiJiang JiaxuanWang ChenchenHu Kai