Ask about this productRelated genes to: TMEM108 antibody
- Gene:
- TMEM108 NIH gene
- Name:
- transmembrane protein 108
- Previous symbol:
- -
- Synonyms:
- MGC3040, CT124
- Chromosome:
- 3q22.1
- Locus Type:
- gene with protein product
- Date approved:
- 2005-12-22
- Date modifiied:
- 2014-11-18
Related products to: TMEM108 antibody
Related articles to: TMEM108 antibody
- Colon cancer is a leading global malignancy with significant health burden. As key regulators of tumorigenesis, microRNAs (miRNAs) are implicated in colon cancer progression, yet the role of miR-1303-its clinical significance and molecular mechanism-remains unclear. This study aimed to investigate the regulatory effects of miR-1303 and validate its potential as an independent prognostic indicator. miR-1303 expression was analyzed qRT-PCR in 117 paired CRC tissues and adjacent normal tissues. Clinical relevance was evaluated Kaplan-Meier survival curves and Cox proportional hazards modeling. Functional assays (CCK-8, Transwell migration/invasion, luciferase reporter) were performed in SW480 and HCT116 cells. Target genes were predicted using miRDB and TargetScan. Rescue experiments confirmed miR-1303 regulates CRC progression by targeting TMEM108. miR-1303 was significantly upregulated in colon cancer tissues compared to normal tissues ( < 0.001) and correlated with advanced TNM stage ( = 0.021), lymph node metastasis ( = 0.005), poor differentiation ( = 0.031), and larger tumor size ( = 0.044). High miR-1303 expression predicted poorer overall survival ( = 0.001) and was recognized as an independent predictor of prognosis (HR = 2.096, 95% CI = 1.080-4.071). Functional studies revealed that miR-1303 inhibition suppressed colon cancer cell proliferation, migration, and invasion. Mechanistically, miR-1303 directly targeted the TMEM108, leading to its post-transcriptional repression. Upregulated miR-1303 in colon cancer served as a poor prognosis predictor. miR-1303 promotes tumor progression in colon cancer by targeting TMEM108. - Source: PubMed
Publication date: 2025/09/24
Cheng QuanFu Huazhou - Prostate cancer (PCa) is a leading cause of cancer-related death in men. Understanding the proteomic landscape associated with PCa risk can provide insights into its molecular mechanisms and pave the way for potential therapeutic interventions. - Source: PubMed
Publication date: 2024/07/27
Sun WenguoLi HaomingShi WenjieLv QuanlongZhang Weili - Cancer testis antigens (CTAs) are a class of immune-stimulating antigens often overexpressed in many types of cancers. The usage of the CTAs as immunotherapy targets have been widely investigated in different cancers including melanoma, hematological malignancies, and colorectal cancer. Studies have indicated that the epigenetic regulation of the CTAs such as the methylation status may affect the expression of the CTAs. However, the report on the methylation status of the CTAs is conflicting. The general methylation profile of the CTAs, especially in colorectal cancer, is still elusive. - Source: PubMed
Abu NadiahRus Bakarurraini Nurul Ainaa AdilahNasir Siti NurmiIshak MuhiddinBaharuddin RashidahJamal RahmanAb Mutalib Nurul Syakima - Parkinson's disease (PD) is a neurodegenerative disorder with the manifestation of motor symptoms and non-motor symptoms. Previous studies have indicated the role of several transmembrane (TMEM) protein family genes in PD pathogenesis. - Source: PubMed
Publication date: 2022/07/04
Zhao YuwenZhang KailinPan HongxuWang YigeZhou XiaoxiaXiang YaqinXu QianSun QiyingTan JieqiongYan XinxiangLi JinchenGuo JifengTang BeishaLiu Zhenhua - Abnormal white matter is a common neurobiological change in bipolar disorder, and dysregulation of myelination in oligodendrocytes (OLs) is the cause. Transmembrane protein 108 (Tmem108), as a susceptible gene of bipolar disorder, is expressed higher in OL lineage cells than any other lineage cells in the central nervous system. Moreover, Tmem108 mutant mice exhibit mania-like behaviors, belonging to one of the signs of bipolar disorder. However, it is unknown whether Tmem108 regulates the myelination of the OLs. - Source: PubMed
Publication date: 2022/04/11
Wu YongqiangZhong YanziLiao XufengMiao XiangguangYu JianboLai XinshengZhang YuMa ChaolinPan HailiWang Shunqi