Ask about this productRelated genes to: TMCO6 antibody
- Gene:
- TMCO6 NIH gene
- Name:
- transmembrane and coiled-coil domains 6
- Previous symbol:
- -
- Synonyms:
- FLJ39769, PRO1580
- Chromosome:
- 5q31.3
- Locus Type:
- gene with protein product
- Date approved:
- 2006-08-21
- Date modifiied:
- 2014-11-19
Related products to: TMCO6 antibody
Related articles to: TMCO6 antibody
- Cerebral small vessel disease (SVD), manifesting as white matter hyperintensities (WMH), lacunar infarctions, and cerebral microbleeds on magnetic resonance imaging (MRI), has been linked to developmental epigenetic alterations. This study aimed to identify and validate gene-specific promoter methylation changes as epigenetic markers associated with SVD, using MRI-defined imaging features and blood inflammatory cells. - Source: PubMed
Publication date: 2026/03/12
Kim JeeyeonPark JihyeKang KeunsooLee Young HoShin Byoung-SooKim Dae-HyunShin Dong-IckAhn Seong HwanKim Jae GukKang Hyun GooJeong HyeseonYum Kyu SunChae Hee-YunKim Do-HyungKim Jei - Long tails trigger tail biting in pigs and increase the risk of flystrike infections in sheep. Tail docking has been a common management practice in both species for decades, but increasingly conflicts with legal animal welfare guidelines. Sustainable solutions require breeding strategies targeting shorter tails. In consequence, the aims were to conduct whole-genome sequencing (WGS)-based genome-wide association studies (GWAS) and comparative genomic analyses (CGA) to explore functional elements influencing tail traits. Phenotypically divergent experimental populations of pigs and sheep were established through unified selection and mating experiments. Tail traits included tail length (TL) measured at birth, and tail abnormalities (TA) assessed radiographically at 14 weeks of age. WGS-based GWAS identified a significant locus on SSC18 in pigs and suggestive loci for TL in both species, which, together with previously reported loci for TA, were further analyzed by CGA. The genomic windows of the significant locus on SSC18 in pigs and the TL GWAS locus on OAR4 in sheep were found to be conserved, harboring six common genes with predicted functional variants. These variants were jointly associated with TL (Plm < 0.05) in both species in linear regression models adjusted for sex, age of the dam, body length, and body weight. In other GWAS locus windows (±1 Mb), species-specific TL candidate genes were identified in sheep (HOXB13, MUC5B, EPB41L3, MTCL1, PIEZO2, MPPE1, and LOXHD1) and in pigs (KNL1, DISP2, SPRED1, TGFB2, and HAND1), each harboring associated putative functional variants. For TA, sheep-specific candidates (PGM2, LRRC66, CRACD, LOC105601916, and SH2D4B) and pig-specific candidates (MYOT, TMCO6, and PCDHAC2) were revealed using logistic regression models (Pglm < 0.05). GO analyses of candidate genes predicted shared biological processes between sheep and pigs, whereas pathway analyses indicated that common carbohydrate metabolism pathways, along with species-specific immune and inflammatory signaling, and pig-specific TGF-β signaling and endochondral ossification, may contribute to tail length variation and abnormalities. These findings provided deeper insights into the genetic basis of differential embryonic tail morphogenesis and perinatal tail development across species. - Source: PubMed
Publication date: 2026/03/03
Zhang XuyingMainzer JohannaGiambra IsabellaYin TongEngel PetraHümmelchen HannahWagner HenrikWehrend AxelEgerer ChristianeGerhards KatharinaReiner GeraldKönig Sven - Neutrophil extracellular traps (NET), formed by the extracellular release of decondensed chromatin and granules, have been shown to promote tumor progression and metastasis. Tumor-associated neutrophils in hepatocellular carcinoma (HCC) are prone to NET formation, highlighting the need for a more comprehensive understanding of the mechanisms of action of NETs in liver cancer. Here, we showed that DNA of NETs (NET-DNA) binds transmembrane and coiled-coil domains 6 (TMCO6) on CD8+ T cells to impair antitumor immunity and thereby promote HCC progression. TGFβ1 induced NET formation, which recruited CD8+ T cells. Binding to NET-DNA inhibited CD8+ T cells function while increasing apoptosis and TGFβ1 secretion, forming a positive feedback loop to further stimulate NET formation and immunosuppression. Mechanistically, the N-terminus of TMCO6 interacted with NET-DNA and suppressed T-cell receptor signaling and NFκB p65 nuclear translocation. Blocking NET formation by inhibiting PAD4 induced potent antitumor effects in wild-type mice but not TMCO6-/- mice. In clinical samples, CD8+ T cells expressing TMCO6 had an exhausted phenotype. TGFβ1 signaling inhibition or TMCO6 deficiency combined with anti-PD-1 abolished NET-driven HCC progression in vivo. Collectively, this study unveils the role of NET-DNA in impairing CD8+ T-cell immunity by binding TMCO6 and identifies targeting this axis as an immunotherapeutic strategy for blocking HCC progression. - Source: PubMed
Song MengjiaZhang ChaoqiCheng ShaoyanOuyang DijunPing YuYang JieyingZhang YaoJunTang YanChen HaoWang Qi-JingLi Yong-QiangHe JiaXiang TongZhang YizhuoXia Jian-Chuan - In North Country Cheviot lambs with early-onset progressive ataxia and motor neuron degeneration, whole-genome sequencing identified a homozygous loss-of-function variant in the ovine transmembrane and coiled-coil domains (TMCO6) gene. The familial recessive form of motor neuron disease in sheep is due to a pathogenic 4 bp deletion leading to a 50% protein truncation that is assumed to result in the absence of a functional TMCO6. This uncharacterised protein is proposed to interact with ubiquilin 1 which is associated with Alzheimer's disease, whereas sporadic forms of amyotrophic lateral sclerosis are caused by variants in UBQLN2. Our findings provide a first spontaneous animal model for TMCO6, which could have implications in the studies of other comparative neurodegenerative diseases. In addition, these results will allow the design of a genetic test to prevent the occurrence of this fatal disease in the affected sheep population. - Source: PubMed
Publication date: 2023/07/23
Letko AnnaBrülisauer FranzHäfliger Irene MCorr EilidhScholes SandraDrögemüller Cord - The samarium(II) calix[4]pyrrolide complex [Sm(NEt)(thf)] (NEt = -octaethylcalix[4]pyrrolide) undergoes selective oxidation of one Sm site on reaction with a range of metal carbonyls giving mixed valence Sm(II/III) complexes. Thus, reactions with TM(CO) (TM = Mo or Cr) entrap M(CO) ions between two mixed valence hosts in [{(thf)Sm(NEt)Sm(thf)(μ-OC)TM(CO)}]·PhMe (TM = Mo, ; Cr, ), while W(CO) on a different stoichiometry traps W(CO) in [{(thf)Sm(NEt)Sm}{(μ-OC)W(CO)}]·PhMe in which the isocarbonyl group is disordered over two sites. In contrast, [Sm(NEt)(thf)] reacts with dicobalt octacarbonyl, (cyclopentadienyl)tetracarbonyl diiron, and dimanganese decacarbonyl to give the mixed valence species [(thf)Sm(NEt)Sm(thf)(μ-OC)TM(CO)]·2PhMe (TM = Co, ; Fe, ) and [(thf)Sm(NEt)Sm(thf)(μ-OC)Mn(CO)]·1.5PhMe . However, both Sm sites of [Sm(NEt)(thf)] can be oxidized as its reaction with cyclooctatetraene (COT) yields the Sm species [(thf)Sm(NEt)Sm(COT)] . The analogous Eu reagent, [Eu(NEt)(thf)] induces C-halogen activation of perfluorodecalin, hexachloroethane, and bromoethane to form the mixed oxidation state species [(thf)Eu(NEt)Eu(μ-X)] (X = F, ; Cl, ; Br, ) despite the use of a sufficient reagent to oxidize both Eu sites. The synthetic potential of the halogenido complexes was illustrated by the reaction of with sodium (trimethylsilyl)amide to give the mixed oxidation state [(thf)Eu(NEt)Eu(N(SiMe))] . - Source: PubMed
Publication date: 2022/11/10
Guo ZhifangWang JunDeacon Glen BJunk Peter C