Ask about this productRelated genes to: TLE1 antibody
- Gene:
- TLE1 NIH gene
- Name:
- TLE family member 1, transcriptional corepressor
- Previous symbol:
- -
- Synonyms:
- ESG1, GRG1, ESG
- Chromosome:
- 9q21.32
- Locus Type:
- gene with protein product
- Date approved:
- 1993-12-13
- Date modifiied:
- 2018-11-15
Related products to: TLE1 antibody
Related articles to: TLE1 antibody
- Primary cardiac synovial sarcoma (PCSS) is an exceedingly rare tumor. This study presents a comprehensive analysis of six novel PCSS cases identified within our institutional cohort, compared with published literature cohorts, focusing on their clinical presentations, histopathological features, immunohistochemical and molecular characteristics, therapeutic interventions, and prognosis. Our institutional cohort included five male and one female patients, with a median age of 44 years. Presenting symptoms included dyspnea, chest tightness, back pain, and syncope. Tumors were located in the pericardium (four cases) and the cardiac wall (two cases). The tumor size ranged from 2.0 to 14.5 cm. Histopathologically, four cases were monophasic and two were biphasic. Immunohistochemical analysis revealed consistent expression of TLE1, vimentin, and BCL-2. Molecular analysis confirmed the presence of the gene fusion through fluorescence in situ hybridization (FISH) in five cases, whereas one FISH-negative case was positive for the gene fusion through next-generation sequencing (NGS). All patients underwent surgical intervention (tumor excision) followed by adjuvant chemotherapy with doxorubicin and ifosfamide. At follow-up, four patients were alive without disease and two had died. This case series highlights the clinicopathologic and molecular features of PCSS. Overall, gene rearrangement and TLE1 expression are crucial diagnostic markers for differentiating PCSS from other neoplasms. - Source: PubMed
Publication date: 2026/04/13
Cai Yi-XiangLiu Sheng-JunSun QiLi HuiMeng Xiao-Le - Papillary thyroid carcinoma (PTC) represents the most prevalent sort of thyroid malignancy, and its incidence has been consistently increasing worldwide. Although most PTC cases exhibit indolent behavior, a subset demonstrates aggressive characteristics, leading to recurrence, metastasis, and poor clinical outcomes. This study aims to unveil the molecular mechanism of PTC and identify potential biomarkers for its early diagnosis and individualized treatment. - Source: PubMed
Publication date: 2026/03/24
Zhai XinyuGu XueZhang ShengcanHuang HanzhaoYe Hui - Neurodevelopmental disorders (NDDs) encompass a wide range of conditions often linked to genetic causes, with mutations in the X-linked gene representing a recurrent contributor. encodes a transcription factor critical for GABAergic neuron development and functioning, regulating the expression of key neurodevelopmental target genes. Variants in result in a wide clinical spectrum, ranging from asymptomatic female carriers to severe developmental syndromes in both sexes. This study investigates the functional impact of 16 variants, including known pathogenic, likely pathogenic, and novel de novo variants, some associated with atypical presentations such as sudden infant death. Using transient expression in N2a neuroblastoma cells, we employed a comprehensive functional approach-including luciferase reporter assays, Western blotting, immunofluorescence, and RT-qPCR-to assess protein expression levels, subcellular localization, their interaction with known corepressors (TLE1 and CtBP1), and their transcriptional activity on selected -known targets. Our results demonstrate that all tested variants disrupt normal transcriptional function, with several also altering protein localization or expression. Remarkably, a subset of variants exhibited dominant-negative effects, offering a compelling explanation for unexpectedly severe phenotypes in female patients, likely exacerbated by skewed X-inactivation and other modifying factors. By integrating experimental data with a literature-based review of published variants, we provide refined genotype-phenotype correlations, highlighting the importance of mutation type, positional context within key functional domains, and patient sex. Altogether, this study advances our understanding of the molecular mechanisms driving -related NDDs, emphasizing the importance of functional testing for accurate variant interpretation and paving the way toward informed genetic counseling and potential therapeutic development. - Source: PubMed
Publication date: 2026/04/07
Faraj RashaFarrugia AudreyHurst Anna C EConan PierreMartin JenniferSchalk AudreyRedon SylviaDubos AlineGras MathildeCurie AuroreVoisset CécileFriocourt Gaëlle - Cancer cells often become dependent on specific molecular functions. As many proteins perform multiple functions mediated by different pockets and interfaces, we hypothesized that we could identify distinct cancer dependencies and therapeutic vulnerabilities by disrupting peptide-binding pockets. To test this hypothesis, we screened a proteome-wide library of 7152 genetically encoded peptides across nine cancer cell lines. We identify common and selective dependencies on peptide-binding pockets and find that gene knockout and peptide-mediated inhibition of pockets often drive divergent phenotypes. For the common-essential gene HCF1, we identify a therapeutic window by using inhibitory peptides with varying affinity. Moreover, peptides targeting TLE1-4 reveal a dependency hidden in genetic screens by homolog redundancy. We also uncover that peptides inhibiting cyclin D drive specific suppression of leukemia cell proliferation and demonstrate that these peptides improve the potency of CDK4/6 inhibitors. Overall, our screening platform facilitates data-driven prioritization of molecular pockets for subsequent therapeutic translation. - Source: PubMed
Publication date: 2026/03/15
Örd MihkelKogan LizBradburn DevinLeiser MichelleKõivomägi MardoDavey Norman ECreixell Pau - Monophasic synovial sarcoma (SS) is a rare and aggressive soft-tissue malignancy that can often resemble benign conditions, making diagnosis challenging. A 13-year-old girl presented with a painless, gradually enlarging swelling in the proximal lower extremity for 4 months. Clinical examination revealed a firm, well-defined, deep-seated swelling, and imaging initially indicated a benign spindle-cell tumor, likely a schwannoma. En bloc excision of the mass was done. Histopathology and immunohistochemistry (positive for TLE1 and BCL2) revealed the diagnosis of monophasic SS. Adjuvant chemotherapy and radiotherapy were given. This case highlights the importance of maintaining a high index of suspicion for malignancy in deep-seated soft-tissue tumors. Early diagnosis, complete surgical removal, and multimodal therapy are crucial for the management of SS. - Source: PubMed
Publication date: 2025/11/14
Singh SunitaKumar AkshayKapoor RohitPrakash DivyaBajpayee Harshit