Ask about this productRelated genes to: THEM2 antibody
- Gene:
- ACOT13 NIH gene
- Name:
- acyl-CoA thioesterase 13
- Previous symbol:
- THEM2
- Synonyms:
- HT012
- Chromosome:
- 6p22.3
- Locus Type:
- gene with protein product
- Date approved:
- 2003-05-02
- Date modifiied:
- 2016-10-05
Related products to: THEM2 antibody
Related articles to: THEM2 antibody
- Low back pain (LBP) is a widespread global health concern that profoundly impairs patients' quality of life and productivity. Intervertebral disc degeneration (IVDD) is considered a major pathological factor in low back pain, yet the underlying mechanisms of IVDD remain incompletely understood. Current treatment strategies primarily focus on symptomatic relief through medication or surgical removal of degenerated tissue, lacking effective interventions that can reverse the degenerative process. This study investigates the role of fatty acid metabolism in IVDD and proposes a novel therapeutic strategy. Through single-cell sequencing and multi-omics analysis of clinical samples, we identified ACOT13 as a key regulator of fatty acid metabolism. We demonstrated that under pathological conditions, ACOT13 inhibits the AMPK/ACC signaling pathway, leading to disrupted fatty acid metabolism, mitochondrial dysfunction, and subsequently, pyroptosis, which accelerates IVDD progression. Furthermore, we developed an innovative self-assembled nanoparticles based on a traditional Chinese medicine formula. Employing molecular dynamics simulations, we elucidate the self-assembly mechanism, identifying the core constituents and establishing the key roles of hydrophobic interactions, π-π stacking, and hydrogen bonding as the driving forces. Moreover, we revealed that this nano-formulation suppresses ACOT13 function, activates the AMPK/ACC pathway, and improves fatty acid metabolism and mitochondrial function, thereby suppressing pyroptosis and ultimately alleviating IVDD progression. In summary, this study explores a novel mechanism of IVDD from the perspective of fatty acid metabolism and identifies key active components (N-QJZG) from a traditional Chinese medicine decoction, providing new insights for IVDD treatment and promoting the modernization of traditional Chinese medicine research. - Source: PubMed
Publication date: 2026/02/08
Qi WeihuiYuan MingchaoHe DuDou FeiZhang DuodanLv KeYang JianyeMiao ZhiminZhang LiangpingMao XinningMei ZhenglinJin HongtingPan HaoWang Dong - Mitochondrial dysregulation contributes to the chemoresistance of multiple cancer types. Yet, the functions of mitochondrial dysregulation in Ovarian serous cystadenocarcinoma (OSC) remain largely unknown. - Source: PubMed
Publication date: 2024/12/29
Shen DongshengWu ChenghaoChen MeiyiZhou ZixuanLi HuaifangTong XiaowenChen ZhenghuGuo Yi - A novel valuable prognostic model has been developed on the basis of immune-related genes (IRGs), which could be used to estimate overall survival (OS) in ovarian cancer (OC) patients in The Cancer Genome Atlas (TCGA) dataset and the International Cancer Genome Consortium (ICGC) dataset. - Source: PubMed
Publication date: 2024/10/31
Yu MinLi DanZhang LiWang Ke - Coronary microembolization (CME) can result in cardiac dysfunction, severe arrhythmias, and a reduced coronary flow reserve. Impairment of mitochondrial energy metabolism has been implicated in the progression and pathogenesis of CME; however, its role remains largely undetermined. This study aimed to explore alterations in mitochondria-related genes in CME. - Source: PubMed
Publication date: 2024/09/23
Jiang ZhaochangLu HaohaoGao BeibeiHuang JinyuDing Yu - Autosomal dominant polycystic kidney disease (ADPKD) is the most common cause of end-stage kidney disease. It has been shown that Acyl-CoA thioesterase 13 () level was reduced in renal cystic tissues from ADPKD patients. However, the role of in ADPKD remains largely elusive. - Source: PubMed
Publication date: 2024/08/21
Wang BinYang QiChe LiheSun LuyaoDu Na