Ask about this productRelated genes to: TH1L antibody
- Gene:
- NELFCD NIH gene
- Name:
- negative elongation factor complex member C/D
- Previous symbol:
- TH1L
- Synonyms:
- HSPC130, TH1, NELF-C, NELF-D
- Chromosome:
- 20q13.32
- Locus Type:
- gene with protein product
- Date approved:
- 2001-07-31
- Date modifiied:
- 2016-10-05
Related products to: TH1L antibody
Related articles to: TH1L antibody
- - Source: PubMed
Huang QingZhao JuanZhang YangZhou YingYang XuyangChen XiaotingWei MingtianHan JunhongZhang Yaguang - Regulation of RNA polymerase II (Pol II) transcription is closely associated with cell proliferation. However, it remains unclear how the Pol II transcription program is rewired in cancer to promote uncontrolled growth. Here, we find that expression of NELFCD, a known negative transcription elongation factor, is upregulated in colorectal tumors. Auxin-dependent protein degradation of NELF-C in combination with nascent transcript sequencing demonstrates a direct role of NELF-C on Pol II transcription in this cancer. Strikingly, we demonstrate that the acute loss of NELF-C protein globally redistributes termination factors and perturbs Pol II transcription termination. These changes drive pervasive Pol II transcription into DNA replication zones, leading to transcription-replication conflict that may block the cell cycle in G1 or early S phase. Our findings reveal a previously unrecognized role of NELF in transcription termination and highlight NELF as a potential therapeutic target in colorectal cancer. - Source: PubMed
Publication date: 2026/02/20
Nakayama ChihiroFang QiDaigaku YasukazuAoi YukiIto ShokoTakahashi MamiShimatani ReoMinamisawa TamikoOzturk YagizKimura HiroshiShilatifard AliTellier MichaelNojima Takayuki - Translational reprogramming enables cancer cells to drive tumour progression and metastasis. eIF3i is a core component of the translational regulatory machinery, but the underlying mechanisms through which it promotes tumour metastasis remain unclear. - Source: PubMed
Publication date: 2025/11/28
Huang QingZhao JuanZhang YangZhou YingYang XuyangChen XiaotingWei MingtianHan JunhongZhang Yaguang - Migraine is a highly prevalent neurological disorder with complex pathophysiology and limited treatment efficacy. Emerging evidence suggests immune cell involvement in migraine, but the specific regulatory mechanisms remain unclear. This study aimed to identify immune cell-type-specific genetic drivers of migraine and prioritize potential therapeutic targets. - Source: PubMed
Publication date: 2025/09/30
Hong YanggangMi YuzeChen FengWang YirongLi JiajunShu Zhendi - To investigate the significance of the negative elongation factor complex member C/D (NELFCD) in colon cancer progression. - Source: PubMed
Dai WeiweiZhu MinSun YujingXu BaohongMa GuorongShi HaiyunLi Peng