Ask about this productRelated genes to: TEX14 antibody
- Gene:
- TEX14 NIH gene
- Name:
- testis expressed 14, intercellular bridge forming factor
- Previous symbol:
- -
- Synonyms:
- CT113
- Chromosome:
- 17q22
- Locus Type:
- gene with protein product
- Date approved:
- 2000-06-16
- Date modifiied:
- 2016-05-06
Related products to: TEX14 antibody
Related articles to: TEX14 antibody
- TEX1 contributes to mRNA export and SA-mediated defense while modulating ABA-driven susceptibility, linking RNA processing to immune regulation in Arabidopsis TEX1, a subunit of the multi-protein THO/TREX complex conserved in eukaryotes, facilitates the synthesis, splicing, and nuclear-cytoplasmic export of mRNAs. However, its mechanism in plants remains to be thoroughly established, particularly its contribution to plant immunity and the mRNA export mechanism in response to pathogen challenges. Here, we showed that TEX1 contributes to mRNA export and hormonal signaling during pathogen infection. The TEX1 mutant was impaired in plant resistance to the Pseudomonas syringae pv. tomato DC3000 and exhibited a compromised salicylic acid (SA) accumulation and reduced expression of SA-regulated genes. Moreover, we show that the pattern-triggered immunity (PTI) response was compromised in the tex1-4 mutant, as it contributes to a reduced defense phenotype upon flg22, leading to reduced flg22-induced defense responses. TEX1 also positively regulates effector-triggered immunity (ETI) against Pto carrying AvrRpm1 and AvrRpt2. Epistasis analysis revealed that TEX1-mediated resistance is SA-dependent. The tex1-4 mutant accumulated elevated abscisic acid (ABA) levels and increased ABA-mediated susceptibility, accompanied by enhanced ABA biosynthesis and reduced expression of catabolic genes. Analysis with sid2-2 further indicated that ABA-induced susceptibility depends on SA signaling, supporting SA-ABA antagonism. Furthermore, the tex1-4 mutation exhibited defective bulk nuclear mRNA export to the cytoplasm upon pathogen infection, as observed by in situ hybridization using 48-mer fluorescein-labeled oligo(dT) probe. Thus, our findings suggest that mRNA export is a crucial component of plant immune activation, with TEX1 serving as a contributing factor that mechanistically links mRNA export with hormone-regulated immune signaling to promote effective plant defense. - Source: PubMed
Publication date: 2026/08/21
Uddin ShahabSilvano Kris JohnChakraborty RupakMacoy Donah MaryRyu Gyeong RyulUgli Rakhimov Abdurakhim RamazonAhn GyeongikKhan HamadCha Joon-YungKim Woe-YeonKim Min Gab - Non-obstructive azoospermia (NOA) is a major cause of male infertility, frequently associated with congenital factors. Nevertheless, the genetic underpinnings of NOA remain largely unclear. - Source: PubMed
Publication date: 2026/01/28
Xu JianzeLi TongtongHu YuweiLi MengjingHu JianlinCai YulingZhang MingyuLu GangChan Wai-YeeChen Zi-JiangLiu HongbinChen Xiang-Feng - The long-term immunological effects of prior Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection in people living with Human Immunodeficiency Virus (HIV) remain poorly understood. This study aimed to characterize plasma proteomic alterations associated with previous SARS-CoV-2 infection in HIV-infected individuals and to identify potential biomarkers and affected pathways. High-throughput liquid chromatography–tandem mass spectrometry (LC–MS/MS) was performed on plasma obtained from three groups: HIV-infected individuals with documented prior SARS-CoV-2 infection, HIV-monoinfected individuals, and healthy controls. A total of 13,675 proteins were identified. Hierarchical clustering and sparse partial least squares discriminant analysis revealed distinct proteomic profiles in the prior-SARS-CoV-2 group. Ten proteins with the highest discriminatory power—PRR11, TEX14, METTL9, NMD3, PXT1, CRISP2, MELK, SPF27, GCP6, and GTPBP8—were associated with cell cycle regulation, RNA processing, apoptosis, mitochondrial function, and cytoskeletal organization. Subcellular localization indicated predominant nuclear and cytoplasmic involvement, suggesting alterations in transcriptional regulation and intracellular structural dynamics. These signatures imply that preceding SARS-CoV-2 exposure may compound HIV-associated immune dysregulation and disrupt cellular homeostasis. The findings offer novel molecular insights into the persistent biological impact of SARS-CoV-2 in the context of HIV and identify candidate proteomic biomarkers with potential utility for risk stratification and targeted intervention in immunocompromised populations. - Source: PubMed
Publication date: 2025/12/09
Chanthara ChayaninKhattiya JanyaRoytrakul SittirukAkekawatchai ChareepornPhaonakrop NarumonNiyomdecha Nattamon - TEX14 is essential for the formation and maintenance of the intercellular bridge (ICB) which is one of the major cellular junctions required for spermatogenesis. Previously, TEX14 was shown to block germ cell abscission prior to cytokinesis through the GPPX3Y (Gly-Pro-Pro-X-X-X-Tyr) motif. Although TEX14 could have the potential to inhibit cell proliferation, it is difficult for full-length TEX14 to be applied as anti-tumour agents because of its molecular size. In addition, the involvement of amino acids surrounding the GPPX3Y motif in the ICB formation as well as cell proliferation remains to be investigated for anti-tumour treatment. In this study, we show that partial peptides of TEX14, which include the GPPX3Y motif, are sufficient to inhibit the proliferation of a variety of cancer cells and efficiently induce apoptosis. In addition, the length and variation of amino acids surrounding the GPPX3Y motif might attenuate the efficiency of partial TEX14 peptides to inhibit cell proliferation as well as to induce apoptosis. Thus, our findings suggest that these TEX14 short peptides could be useful to suppress cell division in continuously proliferating cells such as cancer cells without affecting germ cell differentiation and have the potential as anti-tumour agents. - Source: PubMed
Publication date: 2025/11/11
Iwamori TokukoSakurai YusukeSultana TasrinKatakura YoshinoriIwamori Naoki - SNARE proteins are required for membrane fusion events throughout the endomembrane system, and are therefore associated with vesicular transport. Here, we found that the SNARE family member, YKT6, is indispensable for male fertility in mice. Conditional Ykt6 knockout in pre-meiotic and meiotic germ cells leads to complete sterility and meiotic arrest in male mice, which exhibit loss of spermatocytes in seminiferous tubules, but without obvious disruption of chromosomal behaviours during meiosis. We observed that the abundance of syncytia increases along with abnormal morphology of the Golgi apparatus, while lysosomes decrease in Ykt6-cKO testes. Quantitative proteomics and immunofluorescent staining both showed dysregulation of vesicular transport in YKT6-deficient spermatocytes. Additionally, the recombinant mouse proteins, HA::YKT6 and MYC::STX1A, could interact in vitro, further supporting a likely role in mediating transport vesicle fusion with the plasma membrane. Finally, the absence of TEX14 signal within syncytia and enlarged TEX14 rings between spermatocytes together suggest a failure to stabilise intercellular bridges in Ykt6-cKO testes. These results demonstrate that YKT6 is required for male fertility by promoting meiosis progression through vesicular transport regulation during spermatogenesis in mice, expanding our understanding of YKT6 functions, and suggesting a possible strategy for future interventions for male infertility in humans. - Source: PubMed
Publication date: 2025/06/18
Cen JieYu XiaochenWang ZiqiLiu WenboXu JianzeFang QianGao FeiCao YongzhiLiu Hongbin