Ask about this productRelated genes to: TESC antibody
- Gene:
- TESC NIH gene
- Name:
- tescalcin
- Previous symbol:
- -
- Synonyms:
- TSC, FLJ20607, CHP3
- Chromosome:
- 12q24.22
- Locus Type:
- gene with protein product
- Date approved:
- 2006-02-07
- Date modifiied:
- 2016-04-25
Related products to: TESC antibody
Related articles to: TESC antibody
- Immunotherapies achieve durable responses in several cancers but show limited efficacy in refractory hepatocellular carcinoma (HCC). The mechanisms by which hepatoma cells evade immune recognition and limit immune checkpoint blockade (ICB) efficacy are incompletely defined. Here, we identified tumor-intrinsic tescalcin (TESC) as a previously unrecognized phagocytic checkpoint that contributes to immune evasion and ICB resistance in HCC. Mechanistically, H3K4 methylation drove TESC expression in hepatoma cells, facilitating cytosolic Ca²⁺ buffering and attenuating endoplasmic reticulum (ER) stress-induced calreticulin (CALR) plasma membrane exposure, an essential "eat-me" signal. Consequently, this process abrogates membrane CALR-directed phagocytosis by antigen-presenting cells (APCs), including macrophages and dendritic cells, thereby impairing antigen presentation and subsequent T-cell activation. Clinically, elevated H3K4me3-TESC signaling was a promising prognostic biomarker for poor ICB response of HCC. Importantly, in vivo disruption of this axis restored APC phagocytic function and enhanced the antitumor effects of ICB therapy. Thus, targeting TESC-driven immune escape and its underlying epigenetic regulation may restore APC function and offer a precise therapeutic strategy to enhance immunotherapy efficacy in HCC. - Source: PubMed
Publication date: 2026/04/02
Wang Jiong-LiangWang Jun-ChengPan YangxunHe MinruiZheng ZhikaiZou HaoWu TianqingZhang YuhanHu ZiliFu YizhenPeng WeiYang ZhenyunXu LiZhang Yao-JunChen Min-ShanHu DandanChen JinbinZhao MingChen Dong-PingZhou Zhong-Guo - Electromagnetically induced transparency is a quantum interference effect that eliminates optical absorption in an opaque medium. The resulting narrow transparency window, accompanied by a pronounced slow-light effect, has enabled extensive applications in light storage, quantum information processing, and nonlinear optics. Recently, topological photonic systems have emerged as a powerful platform for robust on-chip light manipulation with topological protection. Here, we demonstrate a form of induced transparency enabled by the supercoupling between a leaky and a guided topological edge state cavity (TESC). The local valley vortices facilitate coupling between TESCs even across a distance of 4.3 wavelengths and induce a transparency window with negligible reflection due to the valley-locked momentum. When the supercoupled TESCs system operates in the strong-driving regime, frequency detuning of TESCs leads to strong mode splitting and a clear avoided crossing. Using an optical pump to photoexcite the all-silicon TESCs in the weak-driving regime, we achieve photo-reconfigurable supercoupling induced transparency (SIT), allowing dynamic control of group delay while maintaining constant transmittance. SIT opens new possibilities for manipulating light flow and controlling slow-light effects, offering promising applications in on-chip optical and quantum information processing. - Source: PubMed
Publication date: 2026/01/27
Wang WenhaoSingh Ranjan - This study investigates the role of Tescalcin (TESC) in promoting myocardial angiogenesis during adaptive cardiac hypertrophy induced by swimming exercise. - Source: PubMed
Publication date: 2025/10/20
Ma ZhichaoDing MingchaoHu YaruiMou CaiyingXun WeiweiCen YanlingSun JunBi RuiQui YanliHuo KekeLiu ZizhangWang XudongYu XuedongJin Li - The prognosis within each subtype varies due to histological and molecular factors. This study leverages omics datasets and machine learning to identify biomarkers associated with EC recurrence in different molecular subtypes. - Source: PubMed
Publication date: 2025/04/28
Hong Jin HwaOuh Yung TaekJeong SohyeonOh YoonjiCho Hyun WoongLee Jae KwanKim HayeonKim ChungyeulRoh SanghyunKim Eun NaChun YikyeongGim Jeong-An - Genome-wide association studies (GWASs) have identified numerous candidate genes for human brain-imaging phenotypes; however, the biological relevance of many of these genes remains unconfirmed. This study aimed to investigate the causal relationships among tescalcin (TESC) (a GWAS-indicated gene), hippocampal volume, Alzheimer's disease (AD), and the underlying biological mechanisms. - Source: PubMed
Publication date: 2024/09/14
Qi JinboSuo XinjunTian ChunxiaoXia XianyouQin WenWang PingTang JieXu JiayuanFu JilianLiu NanaYu ChunshuiShen HuiDou Yan