Ask about this productRelated genes to: TCTN3 antibody
- Gene:
- TCTN3 NIH gene
- Name:
- tectonic family member 3
- Previous symbol:
- C10orf61
- Synonyms:
- DKFZP564D116, TECT3, JBTS18
- Chromosome:
- 10q24.1
- Locus Type:
- gene with protein product
- Date approved:
- 2004-05-27
- Date modifiied:
- 2015-08-26
Related products to: TCTN3 antibody
Related articles to: TCTN3 antibody
- - Source: PubMed
Publication date: 2026/04/08
Arawker Mubeen HusseinHabibullah FitratZhang YiBaral ShantanuFu LijunSun NingLi HongtingJi Fei-HongQiu Xinguang
- Source: PubMed
- Papillary thyroid carcinoma (PTC) lacks reliable molecular biomarkers and effective therapeutic targets. In this study, we investigated whether Signal Transducer and Activator of Transcription 1 (STAT1) promote PTC progression through regulation of tectonic family member 3 (TCTN3). Integrated analyses of TCGA and external datasets identified TCTN3 as a candidate oncogenic factor. Its expression was validated in paired PTC tissues and cell lines using RT-qPCR and western blotting. Functional assays, including CCK-8, EdU incorporation, colony formation, flow cytometric cell-cycle analysis, and Transwell migration/invasion assays, were performed following gain and loss of function of STAT1 and TCTN3. In vivo tumorigenicity was evaluated using nude mouse xenograft models and H&E. TCTN3 was consistently upregulated in PTC and enriched in cell-cycle related pathways. TCTN3 silencing suppressed proliferation, S-phase entry, migration, invasion, and tumor growth, whereas overexpression exerted opposite effects, accompanied by changes in PCNA, Cyclin D1, CDK4/6, MMP2, MMP9, and E-cadherin. STAT1 expression positively correlated with TCTN3 levels and modulated its expression. Chromatin immunoprecipitation and luciferase reporter assays demonstrated direct binding of STAT1 to the TCTN3 promoter, while co-immunoprecipitation confirmed the absence of direct protein interaction. STAT1 depletion phenocopied TCTN3 knockdown, and re-expression of TCTN3 rescued STAT1-deficient phenotypes. Our findings identify a STAT1-TCTN3 regulatory axis that drives cell-cycle progression, migration, and tumor growth in PTC, establishing this pathway as a mechanistically defined contributor to disease progression and a potential therapeutic target. - Source: PubMed
Publication date: 2026/01/23
Arawker Mubeen HusseinHabibullah FitratZhang YiBaral ShantanuFu LijunSun NingLi HongtingJi Fei-HongQiu Xinguang - Joubert syndrome (JS, MIM 213300) is a rare genetic condition characterized by respiratory control disturbances, abnormal eye movements, ataxia, cognitive impairment, and the notable agenesis of the cerebellar vermis. The molar tooth sign visible in magnetic resonance imaging of the brain serves as a diagnostic tool for JS. Variants in the gene can lead to the development of several diseases, including JS type 18, Orofaciodigital syndrome IV, and Meckel-Gruber syndrome. - Source: PubMed
Publication date: 2025/06/13
Lo Giudice MariangelaBorgione EugeniaGiuliano MarikaSanta Paola SandroDi Blasi Francesco DomenicoPettinato RosaRomano CorradoScuderi Carmela - Asthma is one of the most common chronic respiratory diseases affecting children, and there is currently no clear remedy. Immune cells play a key role in childhood asthma. Therefore, a deeper investigation of the correlation between immune cells and childhood asthma could lead to a better understanding of asthma's origin, the identification of potential treatment targets, and the development of personalized treatment strategies. - Source: PubMed
Publication date: 2025/02/21
Zhang YangHai YangSong BangguoXu JingCao LiangjiaYasen RukeyeXu WenjuanZhang JiaxuanHu Jihong