Ask about this productRelated genes to: TCF7L1 antibody
- Gene:
- TCF7L1 NIH gene
- Name:
- transcription factor 7 like 1
- Previous symbol:
- TCF3
- Synonyms:
- -
- Chromosome:
- 2p11.2
- Locus Type:
- gene with protein product
- Date approved:
- 1998-01-20
- Date modifiied:
- 2016-02-01
Related products to: TCF7L1 antibody
Related articles to: TCF7L1 antibody
- While current pluripotency models capture discrete embryonic stages, they inadequately resolve transitional states during peri-implantation development. Here, we establish rosette-formative intermediate stem cells (rfISCs) from mouse embryonic stem cells using the MEK inhibitor PD0325901, the Wnt inhibitor IWR1, and the PKA activator Forskolin. These cells exhibit transcriptomic/epigenetic profiles mirroring those of E5.0‒5.5 epiblasts, bridging rosette-stage and formative pluripotency. rfISCs demonstrate developmental bipotency, retaining in vitro germline differentiation capacity while generating germline-competent chimeras in vivo. Mechanistically, we identified opposing signaling axes that govern rfISC identification through the regulation of lineage priming: IWR1 stabilizes Tcf7l1 to drive Otx2-mediated rfISC specification and neural priming, whereas Forskolin activates PKA to induce Id1-dependent neural suppression. This creates a bistable regulatory circuit in which Otx2/Id1 synergy maintains pluripotency plasticity under MEK inhibition. Notably, rfISCs can be directly derived from E5.25 epiblasts, confirming their physiological relevance. Our work bridges a fundamental gap in pluripotency modeling by capturing the RSC-to-FSC transition through dynamic signaling equilibria. - Source: PubMed
Publication date: 2026/04/17
Chen PengZhu ZhenhuaDong BaoxingJi JunxiangZhu YuqingDuan JunboWu LefanBan QianLiu WenqiangYe Shou-Dong - Androgen receptor (AR) signaling is a central driver of prostate cancer progression, yet the metabolic and transcriptional mechanisms regulating AR expression remain incompletely characterized. This study investigated whether the immunoproteasome inhibitor ONX-0914 suppresses hormone-sensitive prostate cancer (HSPC) through metabolic modulation of AR and aimed to identify the transcriptional mediator involved. - Source: PubMed
Publication date: 2026/03/23
Xian PengFeng ZhenweiYu HaitaoYin HubinChen HaonanShi TenglinLi XilaiZhang ChunlinBai XuesongGou XinLi XinyuanLi Jie - We conducted a Phenome-Wide Association Study (PheWAS) to investigate whether alleles previously shown to be associated with problem behaviors in Labrador Retrievers from the U.S. Transportation Security Administration’s (TSA) odor detection program also show behavioral associations in other populations. The original TSA cohort (2002–2013) consisted of dogs from a former breeding program that drew from U.S. commercial sources and the Australian Customs Service. While those data included TSA testing results from the foster period, detailed behavior profiles and reasons for elimination from the program were not recorded. To extend and validate these genetic associations in populations with richer behavioral data, we analyzed three additional Labrador Retriever cohorts with both genotype and C-BARQ behavioral questionnaire data: (1) Australian pet dogs, (2) UK dogs from a mixed pet and working background (primarily gamebird retrieving), and (3) U.S. working guide dogs. This analysis identified a total of 15 associations between 12 behavioral traits and 8 markers at 6 genome loci. Notably, we found four types of aggression and one type of fear that are directed at familiar humans or dogs, but none directed at unfamiliar ones. Other problem traits identified include separation-related behaviors, excitability, and chasing small animals. Furthermore, we utilized whole genome sequencing to identify a functional candidate associated with “aggression when approached by a household dog at a favorite resting place”. We propose this variant in an intron results in the loss of TCF7L1 protein binding, and we highlight the evolutionary history of that conserved element, including the fixation of two mutations in the human lineage. Our PheWAS findings suggest relevance to working dog selection, breeding, and training, presenting opportunities to reduce costs while improving performance and resilience. - Source: PubMed
Publication date: 2026/03/11
Eyre Alexander WZapata IsainFraire JasminCoty Kevin DHuson Heather JEvans Katy MOtto Cynthia MSerpell James Avan Rooy DianeWade Claire MBlott Sarah CWiener PamelaHaskell Marie JAlvarez Carlos E - Chronic rhinosinusitis with nasal polyps (CRSwNP) is a prevalent inflammatory disorder characterized by nasal obstruction and polyp formation. Despite its prevalence, the complex pathogenesis of CRSwNP remains not fully understood, hindering the development of effective treatments. This study aims to delineate the immunological landscape of CRSwNP by integrating single-cell RNA sequencing (scRNA-seq) and Mendelian randomization (MR) approaches. - Source: PubMed
Publication date: 2025/12/15
Zhang RuxiangFu PeipeiTian Hao - The present study aimed to investigate the involvement of microfibril-associated protein 2 (MFAP2), a multifunctional secreted protein and constituent of extracellular matrix microfibrils, in the tumorigenicity of uterine corpus endometrial carcinoma (UCEC). - Source: PubMed
Publication date: 2025/09/15
Xu KejunShi HongyanWang YanrongDing Huiqing