Ask about this productRelated genes to: ST3GAL6 antibody
- Gene:
- ST3GAL6 NIH gene
- Name:
- ST3 beta-galactoside alpha-2,3-sialyltransferase 6
- Previous symbol:
- SIAT10
- Synonyms:
- ST3GALVI
- Chromosome:
- 3q12.1
- Locus Type:
- gene with protein product
- Date approved:
- 2003-12-05
- Date modifiied:
- 2016-10-05
Related products to: ST3GAL6 antibody
Related articles to: ST3GAL6 antibody
- To construct and validate a diagnostic model for osteonecrosis of the femoral head (ONFH) based on alcohol exposure-related genes using machine learning methods. - Source: PubMed
Tao HongchengLiang FukaiHuang WenboFan SiqiZeng Ping - : Pathogenic ST3GAL3 variants cause neurological and cognitive impairment, defining a distinct congenital disorder of glycosylation (ST3GAL3-CDG). Nonetheless, limited enzyme characterization exists due to the lack of a non-radiochemical assay. : Here, we developed an LC-MS/MS-based method using the artificial substrate para-nitrophenyl-lacto-N-biose (LNB-pNP; Galβ1,3GlcNAcβ1-O-C6H4NO2) to measure ST3GAL3 activity in vitro. : A peak corresponding to sialyl-LNB-NP was detected in reactions with homogenate from HEK-293T cells transfected with pCDNA3 ST3GAL3 plasmid, but was virtually absent in mock-transfected cells. A substrate dependence curve provided an apparent Km value for the substrate (0.40 mM) and closely matched values from prior radiochemical methods. No activity was detected with homogenates from cells expressing pathogenic ST3GAL3 variants, except p.A13D, which is known to retain about 10% of residual activity. Compared to ST3GAL4 and ST3GAL6, ST3GAL3 showed markedly higher specificity toward LNB-NP, lactotetraosylceramide (Lc4) and asialo-GM1, which are rather specific substrates. Instead, neo-lactotetraosylceramide (neoLc4) was processed by all three ST3GALs. : These findings suggest that ST3GAL4 or ST3GAL6 cannot compensate for ST3GAL3 loss in the biosynthesis of gangliosides sialyl-Lc4 and GM1b, but may do so for sialyl-neoLc4. This non-radiochemical assay enables screening and diagnostic evaluation of novel ST3GAL3 variants potentially associated with ST3GAL3-CDG. - Source: PubMed
Publication date: 2026/02/12
Penati SaraDei Cas MicheleMontavoci LindaCaretti AnnaTrinchera Marco - Vesicular stomatitis virus (VSV) is a model rhabdovirus whose infectivity is determined primarily by its envelope glycoprotein (VSV-G). The low-density lipoprotein receptor (LDLR), a cell-surface glycoprotein, has been identified as the major receptor for VSV-G binding. However, the role of host sialylation in VSV-G-dependent entry remains poorly understood. - Source: PubMed
Publication date: 2026/02/22
Isaji TomoyaQi FengChien Yu-ChunOyama YoshiyukiFukuda TomohikoKhoo Kay-HooiGu Jianguo - The microRNA profile in the blood plasma of menopausal women with insomnia, defined by the Pittsburgh Sleep Quality Index (PSQI), was investigated in a two-stage longitudinal study, with 15 participants in each stage and a 12-month interval between them. Twelve women participated at both stages, and no individuals transitioned between groups in stage II. More than 4000 microRNAs and their isoforms were detected across the cohorts. Differential expression analysis revealed that only miR-412-5p was significantly different between the groups in both stages of the study (p < 0.05). Pathway enrichment analysis indicated that three predicted target genes of miR-412-5p (FUT4, FUT1, and ST3GAL6) are components of the glycosphingolipid biosynthesis lacto and neolacto series pathway (hsa00601) (p = 0.87 × 10). These findings suggest that miR-412-5p may represent a promising molecular target for the development of novel therapeutic strategies for insomnia in menopausal women. - Source: PubMed
Publication date: 2026/02/13
Semenova N VRaigorodskaya M PAverinskaya D AMadaeva I MKolesnikov S IGarashchenko N EKolesnikova L I - Shorter leukocyte telomere length (LTL) is an aging biomarker and risk factor for aging-related diseases, including abdominal aortic aneurysm (AAA). This study aimed to identify plasma proteins causally associated with LTL and investigate their roles in linking LTL to AAA. A proteomics analysis was conducted for LTL and a polygenic risk score (PRS) for LTL using 4955 plasma proteins by SomaScan in self-identified White participants (N = 7587-8055) from the Atherosclerosis Risk in Communities (ARIC) study. Replications were evaluated in self-identified Black participants (N = 1668-2094) from ARIC and White participants (N = 2333-2431) from the Cardiovascular Health Study (CHS). Mendelian randomization (MR) analysis assessed causality between LTL and proteins. Survival and mediation analyses explored protein-mediated associations between LTL and AAA risk. In ARIC White participants, 15 unique proteins were identified for LTL or LTL PRS. Three LTL-associated proteins (MZB1, PLOD3, COL28A1) replicated in ARIC Black participants, and six (TNFRSF17, MZB1, CHL1, GDF15, THPO and PLOD3) in CHS White participants. Three proteins associated with LTL PRS (THPO, GP1Bα, PEAR1) replicated in CHS White participants. MR analysis supported causal associations between LTL and five proteins (KDR, TNFRSF17, GDF15, ST3GAL6, CHL1) with all except GDF15 being novel to LTL. LTL was associated with AAA risk (HR = 0.873, 95% CI: 0.803-0.950), with GDF15 mediating 12.4% of this association (p = 0.028). We identified five proteins causally influenced by LTL and highlighted GDF15 as a mediator linking LTL to AAA risk, offering novel insights into aging biology and AAA pathogenesis. - Source: PubMed
Li AixinAustin Thomas RSteffen Brian TJacobson IngridXie JiaqiPankratz NathanLane John AFitzpatrick AnnetteBis Joshua CArking Dan EMosley ThomasSedaghat SanazPankow James SLutsey Pamela LGuan WeihuaTang Weihong