Ask about this productRelated genes to: SQLE antibody
- Gene:
- SQLE NIH gene
- Name:
- squalene epoxidase
- Previous symbol:
- -
- Synonyms:
- -
- Chromosome:
- 8q24.13
- Locus Type:
- gene with protein product
- Date approved:
- 1997-05-15
- Date modifiied:
- 2017-12-15
Related products to: SQLE antibody
Related articles to: SQLE antibody
- is an emerging dermatophytic pathogen causing severe infections that are frequently resistant to standard antifungals. Since 2015, this species has spread intercontinentally. - Source: PubMed
Publication date: 2026/05/06
Gupta Aditya KWang TongLincoln Sara ABakotic Wayne L - Metabolic dysfunction-associated steatotic liver disease (MASLD) and its progressive form, steatohepatitis (MASH), feature excessive hepatic fat accumulation, yet the relative contributions of dietary vs. endogenous fats and their interactions has remained enigmatic. Here, we identify the endoplasmic reticulum-associated E3 ubiquitin ligase MARCHF6 as a pivotal regulator of hepatic lipid metabolism. Global or hepatocyte-specific deletion of Marchf6 induced spontaneous accumulation of triglycerides and cholesteryl esters under chow-fed conditions, revealing a cell-autonomous hepatic defect independent of caloric excess. Loss of MARCHF6 stabilized its substrate squalene epoxidase (SQLE), enhancing sterol pathway flux while concomitantly activating the SREBP1-associated lipogenic transcriptional program and increasing lipoprotein clearance. Accordingly, lipidomic analyses demonstrated remodeling of the hepatic lipidome towards polyunsaturated, long-chain neutral lipids, consistent with increased lipogenesis-driven NADPH consumption. In line with this, pharmacological inhibition of the oxidative pentose phosphate pathway reduced lipid accumulation in MARCHF6-deficient human hepatocytes. Congruently, transcriptomic data from human MASLD/MASH patients revealed reduced hepatic MARCHF6 expression alongside an increase in that of the lipogenic genes SREBF1, FASN, and SCD1. Overall, these data establish MARCHF6 as a multifaceted gatekeeper that integrates sterol turnover, NADPH usage, and lipogenesis to maintain hepatic lipid homeostasis. - Source: PubMed
Publication date: 2026/05/02
Sachdev Vinayvan Loon Nienke MKingma JeninaOttenhoff RoelofTan Josephine M Evan den Berg MarleneDuijst SuzanneJongejan AldoLevels Johannes H MRensen Patrick C NKooijman Sanderde Boer Jan-FrearkKuipers FolkertKuentzel Katharina BKratky DagmarKwon YunZeigerer AnjaHendrix SebastianZelcer Noam - is an emerging dermatophyte associated with extensive, chronic, recalcitrant, and frequently terbinafine-resistant dermatophytosis worldwide. In this study, 30 strains isolated in Italy were investigated. The isolates were obtained from patients originating from Asian countries, from patients from other countries, and from Italian patients who reported no travel outside Italy in the preceding years. Clinical isolates were identified by internal transcribed spacer (ITS) sequencing and analyzed to assess the occurrence and molecular basis of terbinafine resistance. Terbinafine resistance was detected in 18 strains (60%) using a real-time PCR assay. Sequencing of the squalene epoxidase () gene revealed mutations associated with resistance, including L393S in nine strains and F397L in another nine strains. NGS analysis confirmed two terbinafine-resistant strains carrying the L393S and F397L mutations, respectively, and detected the A448T mutation in one terbinafine-susceptible strain. These findings demonstrate the presence of terbinafine-resistant across five regions of Italy and confirm the occurrence of mutations previously linked to antifungal resistance. Data obtained also support a link with endemic Asian areas, other than suggesting the possible occurrence of autochthonous transmission in Italy. - Source: PubMed
Publication date: 2026/04/17
Cruciani DeborahPapini ManuelaPisano LuigiCalcaterra RobertaPietrella DonatellaGaleotti TommasoFazii PaoloMeloscia AntoniaTorricelli MartinaDi Domenico MarcoFiorucci AlessandroSpina SaraCrotti Silvia - Osteosarcoma (OS), the most prevalent primary malignant bone tumor with a dismal prognosis, exhibits significant heterogeneity in programmed cell death (PCD) pathways, but its subtype-specific functional mechanisms remain poorly characterized. This study integrated PCD-related gene signatures to delineate molecular subtypes in OS via consensus clustering, successfully defining four distinct subtypes with divergent prognostic outcomes and immune microenvironments. Differential expression, functional enrichment, and protein-protein interaction (PPI) network analyses revealed subtype-specific PCD pathway associations (e.g., lysosome-dependent cell death, apoptosis, pyroptosis and anoikis), while comparative immune profiling and clinical characterization further refined subgroup identities. A robust prognostic risk model incorporating five pivotal genes (, , , , and ) and metastasis status demonstrated superior predictive performance in both training and external validation cohorts. These findings not only elucidate the functional architecture of PCD across OS molecular subtypes but also establish a clinically actionable model for precision risk stratification and tailored therapeutic strategies. - Source: PubMed
Publication date: 2026/04/11
Zou XinyiRu Yuanfang - Chronic and recalcitrant dermatophytosis has become an increasing therapeutic challenge, particularly in India, where widespread antifungal misuse and environmental factors contribute to persistent infections. This study investigated the clinical patterns, antifungal susceptibility, and molecular mechanisms underlying terbinafine resistance in patients with tinea corporis and tinea cruris. A total of 105 clinically diagnosed and KOH-positive patients were enrolled. The majority were male (60%) with a mean age of 34 years and an average disease duration of 13 months. Most cases involved multiple sites, with the groin, thighs, and buttocks most frequently affected. Phenotypic and molecular identification revealed Trichophyton mentagrophytes/interdigitale complex (Tm/TiC) as the predominant pathogen (97%), followed by rare isolates of Trichophyton rubrum (2%) and Trichophyton indotineae (1%). Antifungal susceptibility testing (CLSI M38-A2) showed high MIC values for fluconazole (MIC₅₀/₉₀: 64 µg/ml), terbinafine (MIC₅₀: 0.5 µg/ml, MIC₉₀: 16 µg/ml), and griseofulvin (MIC₅₀: 2 µg/ml, MIC₉₀: 8 µg/ml), while itraconazole exhibited the best in vitro activity (MIC₅₀: 0.25 µg/ml, MIC₉₀: 0.5 µg/ml). Notably, 33% of isolates demonstrated high terbinafine MICs (≥ 1 µg/ml). SQLE gene sequencing identified mutations, particularly F397L, strongly associated with elevated terbinafine MICs and prior drug exposure. These findings highlight the alarming rise of terbinafine resistance among dermatophytes and underscore the role of inappropriate antifungal use in driving resistance. Regular antifungal susceptibility testing, careful drug selection based on prior exposure, and strict patient compliance are essential for improving outcomes. Until clinical breakpoints are established, treatment should be continued until both clinical and mycological cure are achieved. - Source: PubMed
Publication date: 2026/05/02
Kumari AnitaDas ShuklaSingh Praveen KumarRai GargiSharma SwatiKashyap BineetaPandhi DeepikaJawed ArshadDar Sajad Ahmad