Ask about this productRelated genes to: SPIRE2 antibody
- Gene:
- SPIRE2 NIH gene
- Name:
- spire type actin nucleation factor 2
- Previous symbol:
- -
- Synonyms:
- spir-2, KIAA1832
- Chromosome:
- 16q24
- Locus Type:
- gene with protein product
- Date approved:
- 2004-04-28
- Date modifiied:
- 2018-11-19
Related products to: SPIRE2 antibody
Related articles to: SPIRE2 antibody
- - Source: PubMed
Publication date: 2026/07/14
Razaghizad AmirVasques-Nóvoa FranciscoNi JiayiFerreira João PedroSharma AbhinavHuynh Thao - Elucidating the genetic architecture of body weight (BW), body conformation, and coat color (CC) is vital for the precision breeding of Gamba sheep, a unique high-altitude indigenous breed. While previous studies focused primarily on general plateau adaptation, the specific genetic drivers regulating economic traits in this extreme-altitude population remain poorly understood. In this study, we characterized six key phenotypic traits and conducted genome-wide association studies (GWAS) leveraging whole-genome resequencing data from 296 individuals. To ensure the robustness of our findings, we systematically evaluated five statistical models (GLM, MLM, CMLM, MLMM, and the SUPER model) across different trait categories. The SUPER model was ultimately selected for growth-related traits due to its superior power in balancing signal sensitivity and false-positive control, whereas the MLMM model demonstrated the optimal fitting performance for the binary coat color phenotype, with both models consistently yielding genomic inflation factors ( λ ) close to the theoretical expectation ( 1.0). Phenotypic investigation revealed distinct sexual dimorphism in growth determinants: cannon bone circumference was the primary driver of body weight in rams, whereas body height and heart girth dominated in ewes. The GWAS identified 82 genome-wide significant SNPs, leading to the mapping of a prominent novel genomic region on chromosome 5 associated with body height. Functional annotation highlighted PRKCE and SGIP1 as plausible positional candidate genes for growth characteristics, while SPIRE2 was pinpointed as a primary genomic driver regulating coat color variation. These findings provide novel insights into the genetic blueprint governing growth and pigmentation in this unique livestock, offering precise molecular targets for future marker-assisted selection. - Source: PubMed
Publication date: 2026/06/15
Zhang YangshenZhou HongbinGesang LuobuZhaxi DuojiPubu CirenHong MiaoZhang JipanZhao Yongju - Scanning genomes for selection signals could illuminate the impact of domestication, natural, and artificial selection on the phenotypic traits of cattle breeds. The present study investigated the diverse genomic selection signatures using whole genome sequencing data from 15 pooled samples of five indigenous cattle breeds of Tamil Nadu: Alambadi, Bargur, Kangayam, Pulikulam, and Umblachery. Two approaches, namely composite likelihood ratio (CLR) and fixation index (), were employed to detect selection signatures from the 1,390,449 filtered single-nucleotide polymorphisms. The analysis identified 7250 and 806 genomic regions containing selective sweeps in 1238 and 101 candidate genes using CLR and methods, respectively. These regions were predominantly associated with production traits ( and ), coat colour ( and ), disease resistance ( and ), and adaptation to tropical climates ( and ). Particularly, six regions were shared across all the five cattle breeds, of which, five were intergenic regions and one had a candidate gene, , associated with susceptibility to bovine tuberculosis. A total of 12 candidate genes were common between CLR and methods, relating to production, disease resistance, and behavioural traits. NETWORK analysis revealed six candidate genes allied with calving ease ( and ), milk fat yield (), bovine respiratory disease susceptibility ( and ), and meat and carcass traits (). This study presents the first genomewide map of selective sweeps in Tamil Nadu cattle breeds, providing insights into selection signatures and candidate genes that could enhance genomeassisted breeding for improved production and health. - Source: PubMed
Vani SBalasubramanyam DSingh KaranbirKarthickeyan S M KTirumurugan K GGopinathan AHepsibha PMadhuri B Jaya - We present a large-scale study of structural variation (SV) in the Qatari population, based on short-read whole-genome sequencing (WGS) of 6,141 individuals, identifying 153,946 variants across 5 classes reflecting the region's diversity and evolutionary history. Leveraging consanguinity and biobank phenotypes, we identify >180 putative gene knockouts, and use proteomics to show functional consequences in homozygotes. Conversely, 52 genes show significant depletion of homozygous deletions, eight of which cause severe pediatric disease or murine embryonic lethality. Examining phenotypic extremes uncovers several non-exonic homozygous deletions with large effect, including in SPIRE2 (creatinine), MAGI2 (leanness) and a chr19 microRNA cluster (extreme obesity). Further, SV-GWAS reveals gene-trait associations independent of SNPs, including at ACY1 (acetylation), SLC2A9 (uric acid), UGT1A8 (bilirubin) and ZNF251 (alanine aminotransferase). Notably, 3.2% of Qataris carry findings in medically actionable genes, one-third attributable to SVs. Our findings offer a rich SV reference for a globally understudied population, and demonstrate the utility of consanguineous biobanks for studying SVs in health and disease. All common SVs and tag-SNPs are provided as imputation resource. - Source: PubMed
Publication date: 2026/01/13
Aliyev ElbaySyed NajeebVisconti AlessiaAliyev TaghiBelkadi AzizGhorbani MohammadmersadRossi NiccolòNaeem HaroonGandhi Geethanjali DevadossThareja GauravAl-Maraghi AljaziAamer WaleedIbrahim Amal AbdulsalamShaath RulanAl-Ajli Farooq OmarRazali Rozaimi MohamadSedlazeck Fritz JDavila SoniaAkil AmmiraSuhre KarstenMokrab YounesFalchi MarioFakhro Khalid A - Ulcerative colitis (UC) is a complex chronic inflammatory disease. Centrosome amplification (CA) has been implicated in UC pathogenesis, but its mechanistic role remains unclear. This study aimed to investigate the relevance of centrosome amplification-related genes (CARGs) in UC progression. - Source: PubMed
Publication date: 2025/12/12
Yang ZhenhuanWu XingxingLuo LeiWu XiuxiaWang YuliangHuang TingtingDang ZhongqinNie Shanwen