Ask about this productRelated genes to: SPERT antibody
- Gene:
- SPERT NIH gene
- Name:
- spermatid associated
- Previous symbol:
- -
- Synonyms:
- NURIT, CBY2
- Chromosome:
- 13q14.13
- Locus Type:
- gene with protein product
- Date approved:
- 2006-03-14
- Date modifiied:
- 2016-06-07
Related products to: SPERT antibody
Related articles to: SPERT antibody
- is a crucial gene that regulates body weight and size in several organisms, including the graylag geese (). However, the effect of this gene in swan geese () has been deemed negligible. As various indigenous goose breeds () are systemically selected for their growth performance, a comprehensive understanding of the genetic basis of growth performance-related traits is imperative for goose breeding. - Source: PubMed
Publication date: 2025/12/12
Yang YunzhouZhai ShaojiaLiu HaodongWang HuiyingHe Daqian - Dysregulation of microRNAs (miRNAs) is closely linked to the progression of diverse human diseases. However, the lack of a standardized, fine-grained dataset of miRNA-disease regulatory interactions and the limited ability of existing methods to capture multi-level regulatory relations hinder full understanding of these mechanisms. - Source: PubMed
Publication date: 2025/11/27
Shi JiangchengWang LijunLiu LixueSu Jinhao - Intracytoplasmic spermatid injection into oocytes has limited efficiency in cattle, with no offspring generated so far, partly due to ambiguous spermatid identification. This study aimed to develop and validate a method for isolating and characterizing bovine spermatids to improve the efficiency of spermatid intracytoplasmic injection. First, we optimized a protocol for spermatid isolation from bull testis using a discontinuous Percoll gradient and 10 μm mesh cell strainers. Next, we established a stage-specific separation strategy based on DNA content, size, and granularity using flow cytometry to distinguish round and elongating/elongated spermatids suitable for molecular analysis. Morphological assessment confirmed that 72.5% of isolated cells were at the spermatid stage, supported by a high haploidy rate, spermatid-specific transcript expression (, , , ), and SPERT protein detection. Viability assays showed that spermatids maintained intact DNA at 0 and 24 h at 4°C and 37°C, though mitochondrial activity and ROS levels increased over time, suggesting oxidative stress. When spermatids were injected into oocytes (n = 82), only 13.4% formed two pronuclei, whereas 46.3% exhibited a single pronucleus and a condensed chromatin spot, indicating incomplete activation or fertilization failure. This work contributes to refining bovine intracytoplasmic injection protocols. Future applications of this approach, particularly if functional spermatids can be derived from spermatogonia or embryonic cells, could help shorten the generational interval in cattle breeding. - Source: PubMed
Publication date: 2025/05/16
Pasquariello RolandoDi Filippo FrancescaBonumallu Sai Kamal NagFagali Franchi FernandaPistucci RamonaFranciosi FedericaLodde ValentinaIannuzzi AlessandraLuciano Alberto MariaBrevini Tiziana A LGandolfi Fulvio - Biological parenthood in men with azoospermia can be achieved only by successful surgical spermatozoa retrieval and utilising these spermatozoa to perform intracytoplasmic spermatozoon injection. Spermatozoa retrieval from testes (SPERT) involves removing seminiferous tubules in an attempt to retrieve spermatozoa in men with non-obstructive azoospermia (NOA). Testicular volume and serum follicle-stimulating hormone (FSH) levels are considered to be markers for predicting the success of spermatozoa retrieval from the testes. - Source: PubMed
Publication date: 2025/03/29
Thanikachalam PuvithraRavikuppan GayatriArunkumar SowbarnikaPandiyan RadhaNatarajan Pandiyan - To construct an Alzheimer's Disease Knowledge Graph (ADKG) by extracting and integrating relationships among Alzheimer's disease (AD), genes, variants, chemicals, drugs, and other diseases from biomedical literature, aiming to identify existing treatments, potential targets, and diagnostic methods for AD. - Source: PubMed
Publication date: 2025/04/29
Yang YueYu KaixianGao ShanYu ShengXiong DiQin ChuanyangChen HuiyuanTang JiaruiTang NianshengZhu Hongtu