Ask about this productRelated genes to: SPAG6 antibody
- Gene:
- SPAG6 NIH gene
- Name:
- sperm associated antigen 6
- Previous symbol:
- -
- Synonyms:
- Repro-SA-1, pf16, CT141
- Chromosome:
- 10p12.2
- Locus Type:
- gene with protein product
- Date approved:
- 1999-04-23
- Date modifiied:
- 2016-10-05
Related products to: SPAG6 antibody
Related articles to: SPAG6 antibody
- The human endogenous retrovirus W envelope protein syncytin-1 (syncytin-a in mus) can be involved in fetal development and tumorigenesis. The role of syncytin-1 in male infertility has not been identified. In this study, the prostatic epithelial-specific syncytin-a knockout (syna CKO) mouse model was constructed. First, male infertility, abnormal testicular seminiferous tubule, and prostate gland were discovered in syna CKO mice. Then, irregular sperm motility, morphology, and MMAF-associated gene expression (AKAP3, SPAG6) were detected in syna CKO mice. Increased prostaglandin E2 (PGE2) and prolactin (PRL) modulate the lipid metabolism of the testis in syna CKO mice. Syna CKO with inhibitor or activator treatment identified that syna knockout could inhibit the PI3K/AKT/mTOR pathway, Ca levels, and elevate caspase 3 expression. Therefore, we propose a hypothesis that syna deficiency exacerbates testicular lipid accumulation and apoptosis by suppressing the PI3K/AKT/mTOR and Ca pathway, ultimately leading to spermatogenic dysfunction and male infertility. - Source: PubMed
Publication date: 2026/04/12
Wang QianqianWang ZhenweiLi ZhenpengLiu DongleYan XiaotongZhang YanChi NingBian QiangZhao ZhankuiYu Honglian - The study characterized the sperm proteins of Kokok Balenggek roosters based on molecular weight patterns to investigate the relationship between sperm composition and semen quality. - Source: PubMed
Publication date: 2025/12/30
Jaswandi JaswandiGusdinal HarifMaulana TulusKaiin Ekayanti MulyawatiRusfidra RusfidraAnanda Ananda - [This corrects the article DOI: 10.1371/journal.pone.0333202.]. - Source: PubMed
Publication date: 2026/03/13
Wu TianyuJi XingYun YongyangWang XiaofeiGan YingFan YuZhang Qian - Sperm‑associated antigen 6 (SPAG6) belongs to the cancer/testis antigen family. It is a microtubule‑binding protein located on chromosome 10p12.2 and it plays an important role in various physiological processes, including ciliary movement, immune synapse formation and neurodevelopment. Abnormal SPAG6 expression occurs in multiple malignancies and developmental disorders; however, its underlying molecular mechanisms in tumorigenesis, tumor progression, clinical outcomes and therapeutic response have not been presented. This review provides a comprehensive overview of the physiological functions of SPAG6 and its mechanisms in disease, with a focus on its expression profile, function and association with disease progression and treatment response in hematologic malignancies (e.g., myelodysplastic syndrome, acute myeloid leukemia and B‑cell acute lymphoblastic leukemia) and solid tumors (e.g., breast cancer, lung cancer and osteosarcoma). SPAG6 promotes tumor progression and drug resistance by attenuating the cell cycle and through epigenetic modifications and remodeling of the tumor immune microenvironment. In addition, it may serve as a diagnostic and prognostic marker for various diseases as well as a therapeutic target. - Source: PubMed
Publication date: 2026/02/13
Luo YuYan QibingZhang PohaoXu HuiZhang RongWang RuiheWu Yongkang - Understanding the role and molecular regulation of genes associated with tumour cell motility may be informative for future cancer therapy development. Sperm-associated antigen 6 (SPAG6) gene, encoding an evolutionarily highly conserved flagellar motility protein, is regulated by promoter hypermethylation in breast cancer. Our in silico analysis of healthy and breast cancer tissues from The Cancer Genome Atlas (TCGA) showed tumour-specific SPAG6 promoter hypermethylation in all molecular subtypes. Immunohistochemistry on the independent WSG PlanB breast cancer cohort (n = 2241) confirmed comprehensive down-regulation of SPAG6 on the protein level. In vitro models demonstrated that SPAG6 overexpression in luminal cells exhibited strongly increased migration capacity (p < 0.0001) and characteristics of epithelial-mesenchymal transition (EMT) with actin and E-cadherin displacement. We propose that SPAG6 may have an important role in triggering the EMT program in luminal breast cancer cells, driving tumour progression and metastasis. Trial Registration: ClinicalTrials.gov identifier: NCT01049425. - Source: PubMed
Sechi AntonioMijnes JoleinVillwock SophiaRose MichaelSteib FlorianBringezu SarahBerger JonasSchalla Carmenvon Serenyi SonjaDietrich JanaOrtiz-Brüchle NadinaHeij LaraBednarsch JanGluz OlegNitz UlrikeHarbeck NadiaGraeser MonikaZu Eulenburg ChristineMohammadian Mohammad ParsaJóźwiak KatarzynaKreipe Hans-HeinrichChristgen MatthiasRadner MartinJonigk DannyDahl Edgar