Ask about this productRelated genes to: SPA17 antibody
- Gene:
- SPA17 NIH gene
- Name:
- sperm autoantigenic protein 17
- Previous symbol:
- -
- Synonyms:
- SP17, CT22
- Chromosome:
- 11q24.2
- Locus Type:
- gene with protein product
- Date approved:
- 2000-05-02
- Date modifiied:
- 2015-08-26
Related products to: SPA17 antibody
Related articles to: SPA17 antibody
- Vascular tissue-resident macrophages (VRMs) maintain immune balance in blood vessels, but their role in abdominal aortic aneurysm (AAA) development remains unclear. Here we demonstrated that a specific group of VRMs located in the adventitia marked by expression of Lyve1, protected against AAA by secreting the extracellular matrix protein Sparcl1 (Sc1). Deletion of Sc1 in VRMs promoted dysfunctional lymphangiogenesis and led to the formation of tertiary lymphoid structures (TLSs), thereby accelerating AAA progression. Mechanistically, the calcium-binding domain of Sc1 acted as a trap for the growth factor FGF2, inhibiting FGF2-mediated dysfunctional lymphangiogenesis and expression of genes associated with TLS formation. A therapeutic peptide derived from Sc1 (Spa17) mitigated AAA progression in several AAA models. Our findings reveal that VRM-derived Sc1 has a protective role in AAA and identify a potential therapeutic approach. - Source: PubMed
Publication date: 2026/02/27
Chen Mei-HuaHua Yi-JieLi YanLei YuZhou Si-YuanHu Xi-DeHu Dong-HuaDong Zhi-HuiLu YanZhuang TaoRuan Cheng-Chao - Excessive dieting (ED), a common weight-control strategy, often causes neurological and emotional disturbances, yet its gut-brain interaction mechanisms remain unclear. Employing a short-term dietary (SDR) adult male rabbit model, we found that SDR can induced cerebral cortex up-regulation of the immune-related genes (e.g., C1QC, SAA3) enriched in NF-kappa B signaling pathways, contrasted with down-regulation of sex hormone-related genes (e.g., PRLR, SPA17) implicated in metabolic homeostasis. Furthermore, dysregulated expression of metabolic genes (e.g., PPM1J, GALNT18) in the cecum of the SDR group interacted to impair the immune protection pathways related to intestinal mucosa. Then, SDR significantly increased the cecal Firmicutes/Bacteroidetes ratio (from 3.38 to 5.57) and reduced microbial diversity. Specifically, beneficial bacteria involved in tryptophan metabolism and neurotransmitter synthesis (e.g., Bacteroidales_bacterium, Alistipes_indistinctus) decreased, whereas bile acid-metabolizing bacteria (e.g., Clostridium_sp._CAG:710, Ruminococcus_sp._Marseille-P6503) linked to increase energy metabolism. The top 20 genes from the brain-gut axis analysis (e.g., ITPR1, CAMK4, CDK5R1) were enriched in critical neural pathways like axon guidance, GABAergic synapse, and long-term potentiation. Notably, key neurodevelopmental genes (e.g., GPR37, GPX3) correlated with these microbial shifts, implicating oxidative stress, synaptic plasticity, and mitochondrial function in microbiota-host crosstalk. This study highlights a "microbial-metabolism-neural" axis in SDR, providing novel targets for future obesity intervention strategies. - Source: PubMed
Publication date: 2025/12/08
Li YanhongChen JianningQi XiaolanHe YanWang GuozeWei LiminHong Wei - We aimed to develop a predictive model integrating G2M-related genes to enhance the prognostication of colon cancer. - Source: PubMed
Publication date: 2025/08/10
Song XinDou YanShen Xiaoyong - Reproductive traits of cattle, especially the Nelore breed, have notable importance in the global economy and are recognized throughout the beef cattle production system. Therefore, we aimed to identify regulatory networks of transcription factors (TFs) and the most promising candidate genes for scrotal circumference (SC), testicular hypoplasia (HT), and sexual precocity (SP) that were previously identified in GWAS analysis. We identified 444 genes from a peer-reviewed systematic review related to male reproductive traits. Biological processes were then identified using DAVID 6.8, and a regulatory network of TFs was constructed. Enriched biological processes and seven candidate genes (BICC1, CDH1, FOXG1, GHR, OR52E4, SLC17A7, and ITGA2) were identified, which were associated with some biological processes linked to reproduction. Furthermore, gene-TF networks were obtained from TFs (GABPA, HNF1A, HNF4A, PAX2, and TFAP2A) associated with bovine reproduction, and the 22 most promising candidate genes (CDKN2C, CLPTM1L, GCSAM, GPR12, GTF3A, HSPBAP1, IL32, ILDR1, LOC100141258, LOC100336282, LOC107131530, LOC112449111, LOC618541, LOC781785, MIX23, MTIF3, PARP9, PCED1B, RNASE2, SLC39A2, SPA17 and TMEM253) were found to be specifically linked to sexual precocity. The identified candidate genes and transcription factors have significant potential to influence the evaluated traits in Nelore bulls. Future research and applications of these genetic factors may improve the breeding and enhancement of Nelore cattle. - Source: PubMed
Publication date: 2025/07/25
Silva Evandro NevesDos Santos Thaís Cristina FerreiraVerardo Lucas LimaMagalhães Ana Fabrícia BragaDos Santos Silva Danielly Beraldo - This study aims to summarize the similarities and differences in immune cell characteristics, and potential therapeutic targets between systemic sclerosis-associated interstitial lung disease (SSc-ILD) and idiopathic pulmonary fibrosis (IPF). - Source: PubMed
Shao ShuaiCao SiyuChen YushaZhang ZhijinZhaohui Tong