Ask about this productRelated genes to: SOX10 antibody
- Gene:
- SOX10 NIH gene
- Name:
- SRY-box 10
- Previous symbol:
- -
- Synonyms:
- DOM, WS4, WS2E
- Chromosome:
- 22q13.1
- Locus Type:
- gene with protein product
- Date approved:
- 1998-01-22
- Date modifiied:
- 2019-04-23
Related products to: SOX10 antibody
Related articles to: SOX10 antibody
- - Source: PubMed
Publication date: 2026/04/24
Tauziède-Espariat ArnaultCastel DavidAjlil YassineGrill JacquesSaffroy RaphaëlHasty LaurenMétais AliceBeccaria KevinBoddaert NathalieDangouloff-Ros VolodiaVarlet Pascale - Extra-uterine endometrial stromal sarcoma (EESS) is a rare mesenchymal tumour, and primary gastric involvement represents an exceptionally unusual presentation. Because such tumours present as ulcerated submucosal masses, they are easily misdiagnosed as gastrointestinal stromal tumours (GIST), making accurate, timely recognition critical for appropriate management. A 53-year-old woman presented with a five-day history of epigastric pain, low-grade fever, and malaise. Computed tomography (CT) imaging revealed an 11 cm vascular mass on the greater curvature of the stomach with splenic-hilum and transverse-colon contact, without evidence of local invasion. Upper gastrointestinal endoscopy revealed a friable ulcerated lesion, and biopsies suggested a spindle-cell neoplasm favouring GIST. At laparotomy, the tumour was found to infiltrate the stomach, splenic hilum, colon serosa, and omentum. An en bloc partial gastrectomy, splenectomy, segmental colectomy, cholecystectomy, and omentectomy were performed; final pathology showed microscopic involvement of the gastric radial soft-tissue margin. Histology demonstrated a primary gastric low-grade ESS with a vascular pattern and low mitotic index, while immunohistochemistry showed diffuse CD10/ER/PR positivity and absence of c-KIT, DOG-1, desmin, S100, SOX10, and STAT6, excluding GIST, leiomyosarcoma, PEComa, solitary fibrous tumour, and schwannoma. Targeted RNA-based sequencing identified a canonical JAZF1::SUZ12 fusion, confirming low-grade EESS. Given the tumour's low-grade, hormone-receptor-positive biology and microscopic radial margin involvement, adjuvant endocrine therapy with letrozole (2.5 mg daily) was initiated. At the six-month follow-up, the patient remained asymptomatic with no radiological evidence of recurrence. Primary gastric ESSS remains an exceptional finding and is easily mistaken for GIST. Accurate diagnosis and optimal management depend on comprehensive histology and immunohistochemistry, supported by fusion-gene testing, to guide individualised surgical and adjuvant management. Given the tumour's potential for very late relapse, prolonged surveillance is warranted despite the favourable short-term outcome. - Source: PubMed
Publication date: 2026/03/23
Mylonakis AdamKyros EleandrosKarakeke MariaKarakeke EleniPanagakis AndreasKastanaki PagonaKarydakis LysandrosPergaris AlexandrosSakellariou StratigoulaPapalampros Alexandros - Epithelioid-variant malignant peripheral nerve sheath tumours (EMPNST) are rare in veterinary medicine and typically have poor outcomes. Limb-sparing partial neurectomy is used for distal peripheral nerve sheath tumours but has not previously been described for epithelioid variants. - Source: PubMed
Publication date: 2026/04/08
Spencer-Taylor AlexanderYaffy DylanMarti JuanMiguel-Garcés MariaRaimondi Francesca - Primary dedifferentiated and undifferentiated melanomas are extremely rare and diagnostically challenging. A 55-year-old female patient referred to us with a slowly growing mass in her right popliteal region of 1 year duration, which, on biopsy, performed elsewhere, was diagnosed as a synovial sarcoma. Radio imaging revealed a 6.9-cm-sized intense lesion in the dermis. A review of the biopsy and a subsequent resection revealed malignant cells in the epidermis, exhibiting focal pigmentation (melanin) along with the dermis replaced by malignant spindle cells, arranged in intersecting fascicles. Immunohistochemically, the malignant cells in the epidermis were positive for S100, HMB45, Melan A, SOX10, and PRAME, while the spindle cells in the dermis were completely negative for all those immunostains. Additionally, the malignant spindle cells in the dermis showed diffuse p53 immunostaining (mutation-type) and high Ki67/MIB1. A diagnosis of dedifferentiated melanoma was offered on biopsy, as well as on the resection. On comprehensive genetic testing, the tumor revealed (c.1799T>A) ex11, (c.238C>T) ex2, T (c.722C>T) ex7, and (c.-124C>T) promoter mutations. Post-wide excision, the patient developed multiple pleural and mediastinal tumor deposits on radio imaging. Primary dedifferentiated melanomas are rare and often misdiagnosed as soft tissue sarcomas. A careful assessment of the tumor components, an index of suspicion, relevant immunohistochemical stains, and molecular testing is necessary for an exact diagnosis. These tumors are relatively aggressive and often associated with multiple mutations, including those associated with their aggressive clinical behavior. A review of similar reported tumors in the literature is discussed herewith. - Source: PubMed
Publication date: 2026/04/23
Rekhi BharatBapat PrachiAgaimy AbbasRamadwar MuktaShetty Omshree - Tumours harbouring FET::CREB fusions, particularly those involving EWSR1/FUS and CREM, represent an emerging group that is distinct from and unclassifiable into established categories such as angiomatoid fibrous histiocytoma, clear cell sarcoma of soft tissue, or malignant gastrointestinal neuroectodermal tumour. This study aims to further delineate the clinicopathological, immunohistochemical, and molecular features of these rare mesenchymal neoplasms with EWSR1/FUS::CREM fusions, focusing on diagnostic challenges and aggressive potential. - Source: PubMed
Publication date: 2026/04/23
Zhao MingXu JiayunZheng ShiyuYe LinWang Jian