Ask about this productRelated genes to: SNX4 antibody
- Gene:
- SNX4 NIH gene
- Name:
- sorting nexin 4
- Previous symbol:
- -
- Synonyms:
- ATG24B
- Chromosome:
- 3q21.2
- Locus Type:
- gene with protein product
- Date approved:
- 1999-02-16
- Date modifiied:
- 2014-02-12
Related products to: SNX4 antibody
Related articles to: SNX4 antibody
- Silver halides (AgX, X = Cl, Br, I) are promising materials for various applications, including optical, medical, and electronic technologies, due to their light sensitivity, high refractive index, and antiseptic properties. Silver halides are also important constituents of Pb-free photovoltaic materials such as rudorffites and double halide perovskites. This study presents atomic layer deposition (ALD) processes for the deposition of silver halide thin films using (2,2-dimethyl-6,6,7,7,8,8,8-heptafluorooctane-3,5-dionato)-silver-(I)-triethylphosphine (Ag-(fod)-(PEt)) as the silver precursor and different halide precursors, including TiX, SnX, GaX, and HX (X = Cl, Br, I). The films were deposited on Si substrate at temperatures ranging from 105 to 195 °C. Grazing incidence X-ray diffraction (GI-XRD) revealed the formation of crystalline phases of AgI, AgBr, and AgCl. The choice of the halide precursor significantly affected the film morphology and purity. Titanium tetrahalides led to the most consistent growth-per-cycle (GPC) over the studied temperature range, resulting in films with superior crystallinity and purity. In particular, TiI was identified as the most effective halide precursor which led to AgI films with superior continuity and purity. Although GaX, SnX, and HX precursors showed good performance in terms of GPC, the resulting films exhibited significant sensitivity to the deposition temperature and contained impurities. This study demonstrates that ALD is a robust technique for the controlled deposition of silver halides. - Source: PubMed
Publication date: 2025/11/14
Heidari AidaPopov GeorgiHatanpää TimoWeiß AlexanderChundak MykhailoMizohata KenichiroRitala MikkoKemell Marianna - The global aging population is increasingly inflicted with Alzheimer's disease (AD), but a cure is still unavailable. Neurotrophic factor-α1/carboxypeptidase E (NF-α1/CPE) gene therapy has been shown to prevent and reverse memory loss and pathology in AD mouse models. However, the mechanisms of action of NF-α1/CPE are not fully understood. We investigated if a non-enzymatic form of NF-α1/CPE-E342Q is efficient in reversing AD pathology and carried out a proteomic study to uncover the mechanisms of action of NF-α1/CPE in AD mice. - Source: PubMed
Publication date: 2025/11/26
Xiao LanSharma PranavYang XuyuAbebe DanielLoh Y Peng - During autophagy, the contents enclosed within autophagosomes are degraded, while the outer membrane components are recycled from autolysosomes by the recycler complex through the recently discovered autophagosomal components recycling (ACR) process. This recycling is essential for maintaining autophagic activity. However, the molecular machinery and upstream regulatory mechanisms driving this recycling process remain poorly understood. Here, we identify SNX16 as a key component of the recycler complex, which localizes to autolysosomes and is required for ACR. SNX16 functions in ACR by regulating recycler complex formation, facilitating cargo recognition, and mediating the connection between STX17-SNX4-SNX5 and dynein-dynactin complexes. In addition, SNX16-cargo interactions are regulated by two ACR-related small GTPases, Rab32 and Rab38. Importantly, mTORC1 phosphorylates SNX16 to regulate ACR by inhibiting its interactions with STX17 and other recycler components, thus preventing recycler complex formation. Taken together, our findings identify SNX16 as a recycler component and establish a link between mTORC1 and ACR. - Source: PubMed
Publication date: 2025/11/14
Que HuilinLiu FengpingChen YangTian WenminGao ShuaixinWong Catherine C LLi YanWang ShixuanMeng XianbinRong Yueguang - Type 2 diabetes (T2D) is a complex metabolic disorder strongly influenced by genetics. Most genetic studies, including expression quantitative trait loci (eQTL) analyses, use bulk pancreatic tissue, masking cell-specific mechanisms. Here, by integrating single-cell RNA sequencing, chromatin accessibility, and genome-wide association studies (GWAS) data, we systematically identified 328 pancreatic cell-type-specific cis-eQTLs associated with T2D. We pinpointed nine key genes (including STIL in beta and delta cells; ZSWIM5 in alpha, delta, and ductal cells; IL1RN, ANP32E, IPP, MLLT11, and SLC23A3 in delta cells; SNX4 in gamma cells; and RBMS1 in beta cells) whose SNPs overlapped with chromatin accessibility peaks. These genes highlight regulatory pathways in beta-cell dysfunction, metabolic stress responses, and disrupted pancreatic homeostasis. A public database, CTPeQTLs (https://ctpeqtls.netlify.app/), was developed to explore cis-eQTLs across diabetic and non-diabetic cohorts, revealing distinct regulatory patterns in both endocrine and exocrine cells, as well as disease-associated transcriptional dysregulation. Our findings uncover cell-specific genetic mechanisms in diabetes and provide potential therapeutic targets, supporting precision medicine strategies. - Source: PubMed
Miao Xiao-CaoLi HuiLi QingZhu LeiYu Yan-QiuJi Jian-GuangChen TaoZhang Zhi-GangLi Dong-Xue - High-altitude polycythemia (HAPC) is a prevalent chronic condition affecting individuals at high altitudes, including both highland and plains populations. This study, involving 2248 participants, explored genetic susceptibility to HAPC among ethnic groups, with 898 HAPC patients (450 Han, 448 Tibetan). The Genome-wide Association Study, encompassing 198 cases (100 Han, 98 Tibetan), identified eight Tibetan HAPC-susceptibility single-nucleotide polymorphisms and four in Han individuals. The common polymorphism locus rs7618658 (, < 5 × 10) was validated in both populations. The investigation of Tibetan revealed the rs1374749 locus, along with linked loci, as a potential prevalence factor for HAPC. The GGTAC haplotype containing this locus emerged as a Protect haplotype for HAPC ( = 2.461 × 10, OR = 0.344). Enrichment analysis revealed that Tibetans exhibited susceptibility in oxygen-sensing pathways, such as EPAS1, associated with phenotypes like hemoglobin and platelets. In contrast, Han Chinese showed significant sensitivity in cell differentiation and angiogenesis, closely linked to hemoglobin, hematocrit, and platelets. - Source: PubMed
Publication date: 2025/02/15
Basang ZhuomaZhang ShixuanKe XianweiDuoji ZhuomaYang LaQiangba DanzengDe YangGesang DejiHu ZixinMa YanyunHao MengFan RuidongHan LiLin ZeshanLi YiWang JiucunWu Juan