Ask about this productRelated genes to: SNX4 antibody
- Gene:
- SNX4 NIH gene
- Name:
- sorting nexin 4
- Previous symbol:
- -
- Synonyms:
- ATG24B
- Chromosome:
- 3q21.2
- Locus Type:
- gene with protein product
- Date approved:
- 1999-02-16
- Date modifiied:
- 2014-02-12
Related products to: SNX4 antibody
Related articles to: SNX4 antibody
- In yeast and humans, the conserved DENN-domain (Differentially Expressed in Normal and Neoplastic tissue) protein Avl9 is thought to play roles in membrane traffic and secretion, but its precise function remains poorly defined. Since DENN-containing proteins are associated with Rab GTPase function, we sought to understand Avl9 function in the context of Rab regulation. Here, we show that Avl9 localizes to peripheral punctae that are consistent with secretory vesicles. Moreover, we demonstrate genetic interactions and co-localization between Avl9 and numerous Rabs in the secretory and endosomal pathways, suggesting a potential function at the interface of secretion and recycling. Consistent with this role, avl9▵ results in defective recycling of the endosomal cargo Snc1 but does not alter plasma membrane delivery of an endocytosis-defective Snc1EN- mutant, suggesting that Avl9 is not solely involved in secretory traffic from the trans-Golgi network to the plasma membrane. The avl9▵ recycling defect is exacerbated by additional loss of RCY1 or SNX4, but not VPS35. Each of these three genes contributes to a distinct endosomal recycling pathway, indicating that Avl9 acts in conjunction with multiple recycling pathways. - Source: PubMed
Publication date: 2026/07/16
Rioux Daniel JManj SamreenProsser Derek C - In this work, a series of model inverse coordination complexes composed of one aromatic azine molecule (pyrimidine, pyrazine, 1,2,4-triazine, 1,3,5-triazine, and 1,2,4,5-tetrazine) and two SnX (X = F, Cl, Br, I) molecules has been investigated using quantum chemical calculations. These 1:2 complexes demonstrate a rare structural motif─as evidenced by the Cambridge Structural Database (CSD)─in which a single "naked" azine center forms two N→Sn coordinate bonds simultaneously. Calculations reveal that the two bonds influence one another and, consequently, the 1:2 complexes exhibit longer N→Sn bonds and weaker interactions between the azine and SnX fragments than the corresponding 1:1 conventional complexes. Thus, the studied inverse coordination complexes are characterized by negative cooperative effects (or anticooperativity) between their N→Sn bonds. This conclusion is supported by an occurrence of the destabilizing three-body nonadditive contribution to the total interaction energy calculated at the CCSD(T)/CBS level of theory. The origin of the anticooperativity has been unveiled by the analysis of electron charge distribution and the fundamental physical nature of individual many-body contributions to the total interaction energy. Overall, this work shows how cooperative effects, together with the proper choice of azine center, can modulate the strength of N→Sn bonds in tin(IV) inverse coordination complexes. - Source: PubMed
Publication date: 2026/07/05
Matczak Piotr - Silver halides (AgX, X = Cl, Br, I) are promising materials for various applications, including optical, medical, and electronic technologies, due to their light sensitivity, high refractive index, and antiseptic properties. Silver halides are also important constituents of Pb-free photovoltaic materials such as rudorffites and double halide perovskites. This study presents atomic layer deposition (ALD) processes for the deposition of silver halide thin films using (2,2-dimethyl-6,6,7,7,8,8,8-heptafluorooctane-3,5-dionato)-silver-(I)-triethylphosphine (Ag-(fod)-(PEt)) as the silver precursor and different halide precursors, including TiX, SnX, GaX, and HX (X = Cl, Br, I). The films were deposited on Si substrate at temperatures ranging from 105 to 195 °C. Grazing incidence X-ray diffraction (GI-XRD) revealed the formation of crystalline phases of AgI, AgBr, and AgCl. The choice of the halide precursor significantly affected the film morphology and purity. Titanium tetrahalides led to the most consistent growth-per-cycle (GPC) over the studied temperature range, resulting in films with superior crystallinity and purity. In particular, TiI was identified as the most effective halide precursor which led to AgI films with superior continuity and purity. Although GaX, SnX, and HX precursors showed good performance in terms of GPC, the resulting films exhibited significant sensitivity to the deposition temperature and contained impurities. This study demonstrates that ALD is a robust technique for the controlled deposition of silver halides. - Source: PubMed
Publication date: 2025/11/14
Heidari AidaPopov GeorgiHatanpää TimoWeiß AlexanderChundak MykhailoMizohata KenichiroRitala MikkoKemell Marianna - The global aging population is increasingly inflicted with Alzheimer's disease (AD), but a cure is still unavailable. Neurotrophic factor-α1/carboxypeptidase E (NF-α1/CPE) gene therapy has been shown to prevent and reverse memory loss and pathology in AD mouse models. However, the mechanisms of action of NF-α1/CPE are not fully understood. We investigated if a non-enzymatic form of NF-α1/CPE-E342Q is efficient in reversing AD pathology and carried out a proteomic study to uncover the mechanisms of action of NF-α1/CPE in AD mice. - Source: PubMed
Publication date: 2025/11/26
Xiao LanSharma PranavYang XuyuAbebe DanielLoh Y Peng - During autophagy, the contents enclosed within autophagosomes are degraded, while the outer membrane components are recycled from autolysosomes by the recycler complex through the recently discovered autophagosomal components recycling (ACR) process. This recycling is essential for maintaining autophagic activity. However, the molecular machinery and upstream regulatory mechanisms driving this recycling process remain poorly understood. Here, we identify SNX16 as a key component of the recycler complex, which localizes to autolysosomes and is required for ACR. SNX16 functions in ACR by regulating recycler complex formation, facilitating cargo recognition, and mediating the connection between STX17-SNX4-SNX5 and dynein-dynactin complexes. In addition, SNX16-cargo interactions are regulated by two ACR-related small GTPases, Rab32 and Rab38. Importantly, mTORC1 phosphorylates SNX16 to regulate ACR by inhibiting its interactions with STX17 and other recycler components, thus preventing recycler complex formation. Taken together, our findings identify SNX16 as a recycler component and establish a link between mTORC1 and ACR. - Source: PubMed
Publication date: 2025/11/14
Que HuilinLiu FengpingChen YangTian WenminGao ShuaixinWong Catherine C LLi YanWang ShixuanMeng XianbinRong Yueguang