Ask about this productRelated genes to: SNPH antibody
- Gene:
- SNPH NIH gene
- Name:
- syntaphilin
- Previous symbol:
- -
- Synonyms:
- bA314N13.5
- Chromosome:
- 20p13
- Locus Type:
- gene with protein product
- Date approved:
- 2001-06-21
- Date modifiied:
- 2014-11-19
- Gene:
- SYBU NIH gene
- Name:
- syntabulin
- Previous symbol:
- -
- Synonyms:
- FLJ20366, GOLSYN, KIAA1472, OCSYN, SNPHL
- Chromosome:
- 8q23.2
- Locus Type:
- gene with protein product
- Date approved:
- 2010-04-29
- Date modifiied:
- 2015-11-09
Related products to: SNPH antibody
Related articles to: SNPH antibody
- Proper transport and distribution of mitochondria in axons and at synapses are critical for the normal physiology of neurons. Mitochondria in axons display distinct motility patterns and undergo saltatory and bidirectional movement, where mitochondria frequently stop, start moving again, and change direction. While approximately one-third of axonal mitochondria are mobile in mature neurons, a large proportion remains stationary. Their net movement is significantly influenced by recruitment to stationary or motile states. In response to the diverse physiological states of axons and synapses, the mitochondrial balance between motile and stationary phases is a possible target of regulation by intracellular signals and synaptic activity. Efficient control of mitochondrial retention (docking) at particular stations, where energy production and calcium homeostasis capacity are highly demanded, is likely essential for neuronal development and function. In this review, we introduce the molecular and cellular mechanisms underlying the complex mobility patterns of axonal mitochondria and discuss how motor adaptor complexes and docking machinery contribute to mitochondrial transport and distribution in axons and at synapses. In addition, we briefly discuss the physiological evidence how axonal mitochondrial mobility impacts synaptic function. - Source: PubMed
Publication date: 2009/03/31
Cai QianSheng Zu-Hang - The mouse ortholog of the human GOLSYN gene, termed the m-Golsyn gene, was isolated and mapped to the region on mouse chromosome 15B3.2 syntenic with human chromosome 8q23. Three mRNA species (type la, 1b, and type 2) were produced by use of alternative transcription initiation points and alternative splicing events. The type 1 mRNAs were expressed only in the brain, whereas the type 2 was detected in various tissues. m-Golsyn protein was expressed in various tissues including the brain. Immunohistochemical study of m-Golsyn protein showed its prominent expression in the neuronal cells in various regions of the brain and strong expression in the choroid plexus ependymal cells lining the ventricles. m-Golsyn protein was found to be homologous to syntaphilin, a regulator of synaptic vesicle exocytosis. These results indicate that the m-Golsyn protein may play an important role in intracellular protein transport in neuronal cells of the brain. - Source: PubMed
Funakoshi EishiHamano AyakoFukui MasakiNishiyama NoritoOgita KiyokazuShimizu NobuyoshiIto Fumiaki