Ask about this productRelated genes to: SND1 antibody
- Gene:
- SND1 NIH gene
- Name:
- staphylococcal nuclease and tudor domain containing 1
- Previous symbol:
- -
- Synonyms:
- TDRD11, p100
- Chromosome:
- 7q32.1
- Locus Type:
- gene with protein product
- Date approved:
- 2006-12-19
- Date modifiied:
- 2016-10-05
Related products to: SND1 antibody
Related articles to: SND1 antibody
- - Source: PubMed
Publication date: 2026/04/16
Li YingYang ChengruCui GuoliGui ShiliangJia LinlinChen YuNiu HonglinXin Hua - - Source: PubMed
Publication date: 2026/04/10
Zhan FuliangZhong YanyingQin YunnaLi LiangWu WenwenYao Meizhen - The protein-protein interaction (PPI) between metadherin (MTDH) and Staphylococcal nuclease domain-containing protein 1 (SND1) is a pivotal oncogenic driver in various cancers, yet the atomic-level details of their binding mechanism remain elusive, hindering targeted drug discovery. This study employs integrated computational approaches, including molecular dynamics (MD) simulations, binding free energy calculations, and residue interaction network analysis, to identify hotspot residues at the MTDH-SND1 interface and elucidate the binding mechanism. The results demonstrate that the MTDH-SND1 complex exhibits strong binding affinity, primarily driven by electrostatic and hydrophobic interactions. Structural stability analysis confirmed the complex's integrity during simulations, while dynamic cross-correlation and mutual information analyses revealed a key interaction region (R1) with correlated motions, which was further proved by contact probability analysis. Hydrogen bond analysis identified a stable network involving residues Arg239, Arg243, and Hie263, which were confirmed as hotspot residues by the alanine scanning mutagenesis method. Furthermore, the binding and interaction mechanisms between SND1 and 12 activity-known small molecule inhibitors were investigated and compared with that in the MTDH-SND1 complex. Energy decomposition highlighted that the conserved triad-Arg239, Arg243, and Hie263-is crucial across all systems. This work provides unprecedented atomic-level insights into the MTDH-SND1 interaction and offers a robust structural foundation for the rational design of high-affinity inhibitors against this oncogenic PPI. - Source: PubMed
Publication date: 2026/04/09
Zhu XiChang JiaruiFang MinWu XinyuYin ZhixiangZhang John Z HQi FenghuaZhu TongGao Ya - (CT) infection is one of the most prevalent sexually transmitted infections (STIs) worldwide and has been consistently associated with adverse reproductive outcomes, including female infertility. However, the molecular mechanisms underlying this association remain incompletely understood. This study aimed to investigate whether genes previously associated with female infertility display altered expression patterns in response to CT infection by reanalyzing publicly available transcriptomic data derived from a human in vitro infection model. : An integrative in silico approach was employed. A curated list of 106 genes associated with female infertility was compiled from publicly available databases and integrated with transcriptomic data from the Gene Expression Omnibus (GEO) dataset GSE109428, which profiles primary human fallopian tube mesenchymal cells infected in vitro with CT serovar L2. Gene expression changes were evaluated at two time points (24 and 48 h post-infection) by comparing infected cells with uninfected control samples, followed by functional and phenotype enrichment analyses. : One female infertility-associated gene () was consistently dysregulated at both 24 and 48 h post-infection. In addition, fourteen genes (, , , , , , , , , , , , , and ) became significantly dysregulated exclusively at 48 h post-infection, indicating a time-dependent host transcriptional response to CT infection. Functional and phenotype enrichment analyses revealed associations with biological processes related to embryonic development and meiosis, as well as phenotypes linked to female infertility. These enriched terms were supported by a small subset of genes and were therefore interpreted cautiously. Overall, these findings suggest that CT infection modulates the expression of several infertility-associated genes and may influence biological pathways critical for female reproductive function. While exploratory, this study provides a molecular context that aligns with previously reported associations between CT infection and female infertility. - Source: PubMed
Publication date: 2026/03/01
Rodrigues RafaelaSousa CarlosVale Nuno - Long noncoding RNA (lncRNA) small nucleolar RNA host gene 16 (Snhg16) has been confirmed to accelerate osteoarthritis (OA) progress. However, its regulatory mechanism has not been fully elucidated. - Source: PubMed
Publication date: 2026/02/15
Li QiangYe XiangyangYuan XiaoChen ShengtaoTang HaibinShen LimingHe Shangwen