Ask about this productRelated genes to: SMARCA5 antibody
- Gene:
- SMARCA5 NIH gene
- Name:
- SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5
- Previous symbol:
- -
- Synonyms:
- hSNF2H, hISWI, ISWI
- Chromosome:
- 4q31.21
- Locus Type:
- gene with protein product
- Date approved:
- 1998-10-01
- Date modifiied:
- 2016-10-05
Related products to: SMARCA5 antibody
Related articles to: SMARCA5 antibody
- S. Tong, "Circular RNA SMARCA5 May Serve as a Tumor Suppressor in Non-Small Cell Lung Cancer," Journal of Clinical and Laboratory Analysis 34, no. 5 (2020): e23195, https://doi.org/10.1002/jcla.23195. The above article, published online on 16 January 2020 in Wiley Online Library (wileyonlinelibrary.com), has been retracted by agreement between the journal Editor-in-Chief, Rong Fu; and Wiley Periodicals, LLC. The retraction has been agreed due to concerns raised by a third party, which identified compromised data and systematic issues in the published article. Particularly, during the investigation, relevant inconsistencies regarding the patient data was identified. The authors and their institutes were unresponsive when these concerns were brought to their attention. Accordingly, the article is retracted as the editors have lost trust in the reliability of the data and the results presented. - Source: PubMed
Publication date: 2026/04/13
- The study analyzed the expression of remodeling and spacing factor-1 (RSF-1) and human sucrose nonfermenting protein 2 homologue (hSNF2H) in adenoid cystic carcinoma (ACC) of the salivary gland and their relationship with clinicopathological factors. Immunohistochemical methods were used to detect the expression of RSF-1 and hSNF2H in ACC. Immunofluorescence assay was used to verify the relationship between the expression of RSF-1 and hSNF2H. The effects of RSF-1 and hSNF2H on the proliferation and migration of ACC cells were evaluated by using colony formation assay and wound healing assay. Significant differences in the expression of RSF-1 and hSNF2H in various tissue types of ACC were revealed by immunohistochemical methods. The immunofluorescence experiment results showed that RSF-1 and hSNF2H were co-localized in the nucleus. Knockout of RSF1 or hSNF2H suppressed proliferation and migration of ACC cells. In addition, simultaneous knockout of RSF1 and hSNF2H further reduced viability of ACC cells and prevented cell metastasis. The expression of RSF-1 and hSNF2H was high in ACC, which was closely related to tumor tissue type. RSF-1 and hSNF2H can promote proliferation and migration of ACC cells. - Source: PubMed
Publication date: 2026/04/08
Wang XiaorongGao AichaoLiu XingdongYang Zhe - The solar radiation spectrum, which reaches the Earth's surface, spans from infrared to ultraviolet. In the present study, human skin response to solar-stimulation radiation was assessed via directed protein-protein interaction (PPI) network analysis. Data were extracted from the Gene Expression Omnibus (GEO) database. The gene expression profiles of human skin after exposure to 100J/M versus the control were selected from GSE22083. The data were evaluated via box plot analysis and Uniform Manifold Approximation and Projection (UMAP) plot assessment. The differentially expressed genes (DEGs) were visualized via a Venn diagram. After cleaning the data, the queried DEGs were assessed via the directed PPI network by the application of the CluePedia plugin of Cytoscape software. The critical DEGs were pointed out based on out-degree value. Key actor genes were searched in GeneCards to find a suitable description of them. Among 1482 significant DEGs, AURKA, CENPA, PP2R1B, UBE2O, RPA3, YKT6, SMARCA5, and SMAD3 were identified and highlighted as the critical actor genes in response to solar-stimulated radiation in human skin. In conclusion, AURKA appeared as the top-ranked DEGs in response to solar radiation in the human skin. Based on the findings, AURKA was pointed out as a suitable target against photoaging. The relationship between solar-stimulated radiation and photoaging, cancer promotion, innate immune system, DNA replication, repair of UV damage-induced, vesicular trafficking between the Golgi apparatus and the endoplasmic reticulum, exocytosis of neurotransmitter, exosome production, autophagy, maintenance of nucleosome spacing, and process of progressive fibrosis were established. - Source: PubMed
Publication date: 2025/10/08
Hossein-Khannazer NikooArjmand BabakAsri NastaranRazzaghi ZahraRazi FaridehBandarian FatemehRobati Reza MRezaei MitraAhmadzadeh AlirezaRezaei-Tavirani Mostafa - Ultraviolet (UV) radiation is a major environmental factor that induces DNA lesions. Cells have evolved repair pathways, in which the transcription-coupled nucleotide excision repair (TC-NER) has a central role in removing the lesions. Here we demonstrate that DGCR8, known as a crucial component in microRNA biogenesis, coordinates the UV-induced formation of the TC-NER complex by interacting with TC-NER factors. These interactions could depend on the phosphorylation of Serine 153 of DGCR8, potentially serving as a functional switch from miRNA biogenesis to the TC-NER process. Interestingly, DGCR8 is also involved in recruiting chromatin remodelers, SPT16 and SMARCA5, for the TC-NER initiation, regulating UV-induced DNA/RNA hybrids (R-loops), and modulating DNA replication through the ATR-CHK1 checkpoint pathway. These findings reveal a novel essential regulator of TC-NER independently of miRNA processing and provide new insights into the relevant biological processes and pathological mechanisms. - Source: PubMed
Publication date: 2026/02/03
Watanabe TakaakiYoshinami DaiyuYamasaki HiroyukiTanaka YukikoOhtsuka MasatoTaniguchi Toshiyasu - - Source: PubMed