Ask about this productRelated genes to: SLC44A1 antibody
- Gene:
- SLC44A1 NIH gene
- Name:
- solute carrier family 44 member 1
- Previous symbol:
- CDW92
- Synonyms:
- CDw92, CTL1, CHTL1, CD92
- Chromosome:
- 9q31.1-q31.2
- Locus Type:
- gene with protein product
- Date approved:
- 2004-02-06
- Date modifiied:
- 2018-02-13
Related products to: SLC44A1 antibody
Related articles to: SLC44A1 antibody
- To investigate the clinicopathological and genetic characteristics of papillary glioneuronal tumor (PGNT) and to reclassify cases according to the integrated pathologic-molecular diagnosis with the 2021 World Health Organization (WHO) classification of tumors of central nervous system (CNS). Six tumors diagnosed as PGNT at the Sanbo Brain Hospital, Capital Medical University from January 2010 to August 2025 were collected. Their clinical, imaging, histopathological, and molecular data were retrospectively analyzed. Comprehensive profiling was conducted using hematoxylin and eosin staining, immunohistochemistry, targeted next-generation sequencing, RNA sequencing, and DNA methylation analyses. All tumors were located in the supratentorial cerebral hemispheres. Among the 6 patients, there were 4 males and 2 females, aged 17.0 (10.0, 25.5) years old. Histology revealed a characteristic papillary structure. In four cases, focal and sheet-like neurocytic cells were observed in interpapillary regions, meanwhile two cases showed scattered suspicious ganglion or neuronal cells. Mitoses were rare. The case 4 exhibited focal anaplasia features within the tumor. The papillary-forming cells showed diffuse immunoreactivity for GFAP, OLIG2, S-100, and SOX10. Cells in the interpapillary areas exhibited diffuse or partial synaptophysin positivity, with focal and diffuse positivity for NeuN and calretinin in four cases. The Ki-67 proliferation index was mostly<5% (only one case showed a focal increase to 8%). All cases were negative for IDH1-R132H, H3K27M, and BRAF V600E. Cases 3 to 6 harbored SLC44A1::PRKCA fusions. Cases 1 and 2 had KIAA1549::BRAF and STRIP2::BRAF fusions, respectively. Based on the integrated pathologic-molecular diagnosis, the cases 3 to 6 were definitively classified as PGNT, CNS WHO grade 1, while the case 4 showed focal anaplasia. By integrated with DNA methylation profiling, the case 1 and 2 were reclassified as low-grade glioma/low-grade glioneuronal tumor, not elsewhere classified. The 6 patients underwent craniotomy with gross total or subtotal tumor resection. One of them also received local radiotherapy. At the last follow-up (July 2025), all patients were alive without recurrence or progression. The overall survivals were 105, 50, 66, 64, 12, and 6 months, respectively. PGNT is a rare glioneuronal tumor characterized by a biphasic pattern with pseudopapillary glial architectures and interpapillary neuronal components. The presence of focal and sheet-like NeuN-positive neurocytic cells in the interpapillary regions is a significant diagnostic clue for PGNT. Integrated pathologic-molecular analysis is essential for accurately classifying supratentorial papillary glioneuronal tumors. Classic PGNTs are molecularly defined by recurrent PRKCA fusions, while BRAF-altered cases warrant reclassification. - Source: PubMed
Duan Z JYang J JFeng JMa ZZhang X FHu Z JXiang LQi X L - Nasopharyngeal carcinoma (NPC) is associated with aberrant cellular metabolism and interactions between tumor and stromal cells. This study aims to elucidate the role of glycerophospholipid metabolism in NPC, particularly focusing on the interplay between malignant epithelial cells and fibroblasts. - Source: PubMed
Publication date: 2026/05/20
Wang LipingWang DujuanLi ShuangLiu GuohongLi YirongPan Yunbao - Hyperuricemia is a common metabolic disorder and has become a global health concern. This study investigated the association between DNA methylation (DNAm) and serum uric acid (SUA) by conducting an epigenomewide association study (EWAS) in Chinese monozygotic (MZ) twins. Genomewide DNAm of 50 MZ twin pairs was profiled using the Infinium MethylationEPIC v2.0 BeadChip (935K). Generalized estimating equations (GEE) were used to examine the association between DNAm and SUA. Causal relationships between DNAm and SUA were assessed using ICE FALCON approach. Associations between mRNA expression and SUA were further assessed. Finally, candidate genes identified through epigenomewide association study (EWAS), causal inference, and gene expression analyses were validated in a longitudinal twin study. We identified 70 CpGs, mapping to genes such as and , significantly associated with SUA (Bonferroni correction < 5.8 × 10). Causal analyses revealed one CpG with a causal effect of DNAm on SUA, 22 CpGs with causal effects of SUA on DNAm, and 33 CpGs showing bidirectional causality. Eleven genes displayed expression levels associated with SUA. , , , and were selected as candidate genes, all of which showed unidirectional causal effect of SUA on DNAm. In the longitudinal analysis, baseline SUA levels (2012-13) were associated with subsequent DNAm levels in and genes (2023-24). In conclusion, we found that SUA levels may influence DNAm variations, particularly at CpG loci within the and genes. These findings provide key clues for future investigations into the mechanisms linking SUA with its epigenetic regulatory pathways. - Source: PubMed
Publication date: 2026/05/21
Yang RunshengLuo JiaZhang DongfengTian XiaocaoWang Weijing - The organic cation choline is essential for eukaryotic metabolism. Recently, the feline leukemia virus subgroup C receptor-related (FLVCR, SLC49) family was demonstrated as central for basal choline transport, questioning the role of the choline transporter-like (CTL, SLC44) family in this capacity. Here, we use oocytes to confirm that FLVCR1 (SLC49A1) and FLVCR2 (SLC49A2) proteins are choline transporters. CTL1 (SLC44A1) does not transport choline under the same conditions, supported by other CTL proteins, CherI and PNS1, which also display no choline transport activity. We present the atomic structures of FLVCR2, CTL1, and PNS1. The 3.4 Å cryo-EM structure of FLVCR2 has choline in the binding pocket. The 3.3 Å cryo-EM structure of CTL1 and the 2.7 Å crystal structure of PNS1 reveal an unusual protein fold, weakly related to the mitochondrial carrier family (SLC25). The unusual fold appears incompatible with transmembrane transport and implies a different and, so far, unknown function for CTL proteins. Our results support FLVCR proteins as choline transporters and suggest a nontransport role for CTL proteins. - Source: PubMed
Publication date: 2026/05/11
Nel LynetteDriller Jan HDriller RonjaFrain Kelly MPedersen Bjørn P - Multiple myeloma (MM) remains incurable despite effective therapies, with most patients eventually relapsing. Chimeric antigen receptor (CAR) T-cell therapy has improved treatment options but is limited by antigen escape and lack of durable responses. To expand the spectrum of actionable antigens, we sought to identify novel CAR-T actionable targets. - Source: PubMed
Publication date: 2026/01/13
Garofano FrancescaCorsale Anna MariaBiondo MartaRomano AndreaSchmidt-Wolf IngoGullà Anna MariaSiragusa SergioBotta Cirino