Ask about this productRelated genes to: SLC3A2 antibody
- Gene:
- SLC3A2 NIH gene
- Name:
- solute carrier family 3 member 2
- Previous symbol:
- MDU1
- Synonyms:
- 4T2HC, 4F2, NACAE, CD98, CD98HC, 4F2HC
- Chromosome:
- 11q12.3
- Locus Type:
- gene with protein product
- Date approved:
- 1994-02-15
- Date modifiied:
- 2016-02-17
Related products to: SLC3A2 antibody
Related articles to: SLC3A2 antibody
- PTDSS1 is an emerging oncogenic protein associated with poor survival rates across various cancer types, including esophageal squamous cell carcinoma (ESCC). However, its regulatory mechanisms and therapeutic potential in ESCC remain incompletely understood. Through single-cell RNA sequencing (scRNA-seq) analysis, we identified a PTDSS1-high malignant epithelial subpopulation characterized by resistance to ferroptosis and mitophagy. Our investigations demonstrated that PTDSS1 regulates glutathione (GSH) synthesis and coordinates mitophagy in ESCC cells. Mechanistically, PTDSS1 knockdown promotes interaction between TRIM21 and SLC3A2, leading to diminished SLC3A2 protein expression and subsequent reduction in GSH synthesis. This elevates cellular oxidative stress, thereby triggering PINK1/Parkin mitophagy pathway and ultimately inducing apoptosis and ferroptosis. Furthermore, at the mitochondrial level, the knockdown of PTDSS1 decreases phosphatidylserine (PS) and facilitates mitochondrial fusion protein 2 (MFN2) translocation, providing substrates for mitophagy. Collectively, our findings elucidate a novel mechanism by which PTDSS1 protects ESCC cells from death and offer new perspectives for therapeutic strategies that target PTDSS1 to induce mitophagy and ferroptosis in ESCC. - Source: PubMed
Publication date: 2026/04/23
Zhang XiaoCao ShuruiZhou ChenchenJiang WenWang HongshunHui BingqingDeng XiahengGu Yanhong - Osteoarthritis (OA) represents the most common degenerative joint disease, with emerging evidence linking it to lysosomal dysfunction and ferroptotic cell death. This study aimed to identify candidate biomarkers associated with lysosomal function and ferroptosis in OA, thereby providing a theoretical basis for subsequent experimental research. - Source: PubMed
Publication date: 2026/04/21
Fan YuFan FurongXie JunhaoChen GuoliangXu JingzheYang Chengbin - Endothelial dysfunction under high-glucose conditions is a key pathological process contributing to the development and progression of diabetic osteoporosis (DOP). High glucose-induced damage to H-type vascular endothelial cells (H-type ECs), including mitochondrial dysfunction, increased lipid peroxidation, and activation of ferroptosis, is considered a potential mechanism underlying bone loss and dysregulated bone metabolism in DOP. Diabetic osteoporosis is a common and severe complication in patients with diabetes, and current clinical treatment options remain limited. Ginsenoside Rg1 (Rg1), one of the main active components of ginseng, has been shown to possess antioxidant and anti-osteoporotic effects, but its underlying mechanisms in DOP remain unclear. - Source: PubMed
Publication date: 2026/03/17
Chen MiZheng HongxiangBai RuiHuang YingjiePang GuoyuZhu HaixiaYi ZhuoxinChen Wenhui - Airway inflammation is one of the primary pathological characteristics of asthma. Soufeng Yuchuan (SFYC) decoction, a compound formula derived from multiple traditional Chinese medicine prescriptions, is widely applied clinically and exhibits significant therapeutic efficacy against asthma. However, its anti-asthmatic mechanisms remain incompletely understood. - Source: PubMed
Publication date: 2026/03/30
Zhang YujingLiang LeiZhang XinxinYan Yongbin - Diabetic nephropathy is a leading complication of diabetes mellitus and poses a significant public health challenge. Ferroptosis has emerged as a critical pathological factor that exacerbates the progression of diabetic nephropathy. While previous studies have demonstrated the antiferroptotic effects of curcumol (Cur), its therapeutic potential in treating diabetic nephropathy, along with the underlying mechanisms, remains to be fully elucidated. - Source: PubMed
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