Ask about this productRelated genes to: SLC27A2 antibody
- Gene:
- SLC27A2 NIH gene
- Name:
- solute carrier family 27 member 2
- Previous symbol:
- FACVL1
- Synonyms:
- FATP2, hFACVL1, VLACS, VLCS, HsT17226, ACSVL1
- Chromosome:
- 15q21.2
- Locus Type:
- gene with protein product
- Date approved:
- 1999-08-20
- Date modifiied:
- 2016-02-17
Related products to: SLC27A2 antibody
Related articles to: SLC27A2 antibody
- This study aimed to determine whether fatty acids (FAs) may affect the function of the early porcine placenta. First, the expression of FA transporters (CD36, SLC27A) in conceptuses and placentae of days 10-11, 12-13, 15-16, 18-20, 25, and 30 pregnant gilts (n = 5-8 per group) was examined using Real-time PCR, Western blot, and immunohistochemistry. Then, primary trophoblast (pTr) cells from days 15-16 conceptuses were exposed to n-6 and n-3 polyunsaturated FAs (PUFAs) to study prostaglandin (PG) synthesis and the expression of genes related to FA action, angiogenesis, steroidogenesis, and lipid transport. Furthermore, pTr cell proliferation and adhesion in response to PUFAs were determined colorimetrically. Increased mRNA expression of CD36, SLC27A1, and SLC27A2 was detected in days 18-25 placentae compared with days 10-13 conceptuses. SLC27A4 and SLC27A6 expression was greater in days 10-11 spherical than in days 15-16 elongated conceptuses. SLC27A1, SLC27A4, and SLC27A6 were localized at the placenta-endometrium interface. PUFAs of n-6 series elevated PGE2 and PGI2 synthesis, whereas n-3 PUFAs stimulated PGE2 but inhibited PGI2 output. All PUFAs up-regulated the mRNA expression of CPT1A, a rate-limiting enzyme of FA β-oxidation. Moreover, docosahexaenoic acid (DHA) increased FABP5, SLC27A4, LDLR (lipoprotein receptor), and proangiogenic ANGPT1 and ANGPTL4 mRNA expression. DHA and arachidonic acid stimulated pTr cell proliferation, while linoleic and eicosapentaenoic acids increased cell adhesion. These results are the first demonstrating dynamic changes of FA transporter expression in peri-implantation conceptuses and developing placentae of the pig and indicate FA uptake by the early placenta. Furthermore, PUFAs may support placenta development by modulating gene expression, increasing PGE2 level, and promoting trophoblast cell viability and adhesion. - Source: PubMed
Publication date: 2026/05/02
Blitek AgnieszkaSzymanska Magdalena - Lipid metabolism is crucial for the development of insulin resistance. Leucine supplementation enhances insulin sensitivity and lipid metabolism. Soybean oil has the potential to improve insulin sensitivity. A comprehensive investigation of the effects and potential mechanisms of leucine and soybean oil supplementation is warranted. This study aims to investigate the effects and underlying mechanisms of maternal soybean oil and leucine intake on lipid metabolism, insulin sensitivity in both dams and offspring. - Source: PubMed
Publication date: 2026/04/10
Sun YutongGan ZexuanLi XueyuanLin YuxinMa QingquanZhou Xinbo - Dysregulated fatty acid (FA) metabolism sustains tumour growth and metastasis, yet effective therapeutic interventions remain elusive. Fatty acid transport protein 2 (FATP2/SLC27A2) has emerged as a pivotal metabolic gatekeeper, coordinating the uptake and activation of long-chain fatty acids (LCFAs). Despite its established role in driving tumour-associated immune suppression and metabolic dependencies, FATP2-directed drug discovery is limited by the lack of high-resolution structural information. This review integrates recent biological insights with computational and structural informatics, assessing reported chemotypes against available homology and AlphaFold-derived models to propose a rational, structure-based framework for next-generation FATP2 inhibitor design and prioritization. - Source: PubMed
Publication date: 2026/04/22
Wang YuanyuanZhang YunjiaoZhang BoKhan Faez Iqbal - This experiment investigated the effects of dietary Krasch. (AOK) supplementation on the n3-polyunsaturated fatty acid (n3-PUFA) profile of subcutaneous adipose tissue (SADT) in Arbas cashmere goats and explored the underlying transcriptional mechanisms. Forty healthy, weaned kids (120 ± 10 days of age; similar body weight) were randomly allocated to two groups ( = 20): a control group (CON, basal diet) and an AOK group (AOK, basal diet with 3% of the roughage replaced by AOK). The feeding trial spanned 104 days, consisting of a 14-day adaptation period and 90 days of data acquisition. Compared with the CON group, AOK significantly reduced the content of saturated fatty acids (SFAs) and n6-polyunsaturated fatty acids (n6-PUFAs)/n3-PUFAs (n6/n3). In contrast, the levels of n3-PUFAs in the SADT of cashmere goats increased markedly ( < 0.05). Compared with the CON group, AOK exhibited significantly higher activities of hormone-sensitive lipase (HSL) ( = 0.027), adenylyl cyclase 2 (ADCY2) ( = 0.010), adenylyl cyclase 5 (ADCY5) ( = 0.046), cluster of differentiation 36 (CD36) ( = 0.013), solute carrier family 27 member 4 (SLC27A4) ( = 0.021), and fatty acid binding protein 4 (FABP4) ( = 0.040), along with significantly lower activities of fatty acid synthase (FAS) ( = 0.002), lipoprotein lipase (LPL) ( = 0.048), and stearoyl-coa desaturase (SCD) ( = 0.026) in SADT. Compared with the CON group, the activities of superoxide dismutase (SOD) ( = 0.032), catalase (CAT) ( = 0.010), glutathione peroxidase (GSH-PX) ( = 0.029), and total antioxidant capacity (T-AOC) ( = 0.002) were significantly increased in the AOK group. Transcriptomic profiling revealed that AOK supplementation downregulated mRNA levels of , 5, , , , 1 (1), stearoyl- 2 (2), 1 (1), 1 (1), (), 1 (1), 1 (1), 27 2 (272), 4 (4), and 1 (1) ( < 0.05). It also markedly induced 4 (4) ( < 0.01) in SADT. Genes significantly enriched in the adenosine-monophosphate-activated protein kinase (AMPK) signaling pathway included , 1, 1, and 1 ( = 0.010). Genes significantly enriched in the phosphatidylinositol 3-kinase-akt (PI3K-Akt) signaling pathway included 1 and 4 ( = 0.015). 1, 2, and 1 were identified as the genes significantly enriched in the insulin resistance signaling pathway ( = 0.048). was the only gene significantly enriched in the cholesterol metabolism pathway ( = 0.049). Genes showing a tendency toward significant enrichment in the peroxisome-proliferator-activated receptor (PPAR) signaling pathway included 4, 1, 1, and ( = 0.051). These interconnected cascades improve insulin sensitivity, stimulate triglyceride (TG) hydrolysis, and modulate n3-PUFA levels. Supplementation with AOK enhances n3-PUFA content by accelerating TG breakdown while simultaneously restraining FA oxidation in SADT. Consequently, AOK supplementation can be effectively used to enhance the nutritional value of cashmere goat meat through improved n3-PUFA deposition in SADT. - Source: PubMed
Publication date: 2026/04/02
Jiang LianguangZhao YanliZhang QingyueZhang ShangxiongGuo XiaoyuGuo YongmeiYan Sumei - Pine nut oil (PNO) is a candidate alternative to corn oil (CO) owing to comparable unsaturated fatty-acid profiles and enrichment in pinolenic acid (Δ5-18:3) and lipid-soluble micronutrients. We systematically compared extraction routes (solvent, supercritical CO₂, pressing), established solvent extraction as the optimal balance of yield and bioactive retention, and then characterized solvent-extracted oils from eight provenances using a weighted composite score to nominate Pinus tabuliformis for in vivo testing. In diet-induced obese mice (12-week Western diet, then 12-week intervention, n = 10 per group), replacing CO with PNO lowered body-mass gain and liver weight and improved serum lipids (triglycerides ↓ ∼ 28 %, total cholesterol ↓ ∼ 15 %, LDL-C ↓ ∼ 20 %) without affecting HDL-C or glucose; ALT and AST fell by ∼30 %, indicating hepatoprotection. Hepatic multi-omics revealed coherent remodeling toward PUFA-rich phospholipid species, activation of PPAR-centered peroxisomal/mitochondrial fatty-acid degradation and circadian pathways, and integrative correlations implicating Cyp4a10/14, Ehhadh, Slc27a2, Fgf21, Angptl4, and Plin5. Collectively, PNO reoriented hepatic lipid flux toward oxidation and membrane remodeling, supporting its development as a nutritionally advantaged culinary oil. - Source: PubMed
Publication date: 2025/12/26
Zhang YirenZeng WeiLiu YuanfaWang Xingguo