Ask about this productRelated genes to: SLC17A1 antibody
- Gene:
- SLC17A1 NIH gene
- Name:
- solute carrier family 17 member 1
- Previous symbol:
- NPT1
- Synonyms:
- NAPI-1
- Chromosome:
- 6p22.2
- Locus Type:
- gene with protein product
- Date approved:
- 1994-05-25
- Date modifiied:
- 2016-02-17
Related products to: SLC17A1 antibody
Related articles to: SLC17A1 antibody
- , which encodes for a transcriptional repressor, is associated with fasting blood glucose (FBG) levels and increased type 2 diabetes (T2D) risk but its role in cell types involved in glucose metabolism is not well understood. Here, we show that the deletion of in the human pancreatic β-cell line EndoC-βH1 did not impair glucose-stimulated insulin secretion (GSIS) nor perturb its transcriptome. On the other hand, we found that ZHX3 represses the expression of gluconeogenic genes and in the human hepatoma line HepG2. Transcriptomic analysis of -deficient HepG2 cells revealed that the uric acid transporter gene was up-regulated, which consequentially led to increased uric acid secretion. High levels of uric acid could then impair GSIS in EndoC-βH1 cells. Subsequently, in-depth co-immunoprecipitation followed by mass spectrometry analysis of ZHX3 in HepG2 cells identified transcription factor CEBPB as its binding partner, required to repress the transcription of , , and partially in HepG2 cells. Overall, our study uncovered the role of ZHX3 in regulating glucose metabolism in hepatocytes, thereby influencing FBG levels and their association with T2D risk. - Source: PubMed
Publication date: 2024/12/20
Tan Wei XuanLim Lillian YuxianAfsha NeshaChan Gloria Mei EnChing CarmenOguz GokceNeo Suat PengMohamed Ali SafiahRamasamy AdaikalavanGunaratne JayanthaHunziker WalterKhoo Chin MengTeo Adrian Kee Keong - To summarize the effects of single nucleotide polymorphisms (SNPs) on the pharmacokinetics of allopurinol to control uric acid levels. A comprehensive search was conducted in PubMed, Web of Science and Scopus databases from inception to January 2024, includes 17 articles focusing on SNPs and pharmacokinetics of allopurinol and oxypurinol. A total of 11 SNPs showed a significant association with pharmacokinetics of allopurinol and oxypurinol, as well as their potential clinical implications. SNPs in ATP-binding cassette super-family G member 2 (), solute carrier family 2 member 9 (), solute carrier family 17 member 1 (), solute carrier family 22 member 12 (), solute carrier family 22 member 13 () and PDZ domain containing 1 () genes were associated with allopurinol clearance, while SNPs in aldehyde oxidase 1 () genes involved in metabolism of allopurinol. SNPs in gremlin 2, DAN family BMP antagonist () gene impacted uric acid control, but the specific mechanism governing the expression of remains unknown. Our study indicated that the identified SNPs show contradictory effects, reflecting inconsistencies and differences observed across various studies. - Source: PubMed
Publication date: 2024/09/30
A Zairol Azwan Farah AidaTeo Yi YingMohd Tahir Nor AsyikinSaffian Shamin MohdMakmor-Bakry MohdMohamed Said Mohd Shahrir - The minor allele of the common rs2231142 ABCG2 variant predicts inadequate response to allopurinol urate lowering therapy. We hypothesize that additional variants in genes encoding urate transporters and allopurinol-to-oxypurinol metabolic enzymes also predict allopurinol response. - Source: PubMed
Fanning Niamh CCadzow MurrayTopless Ruth KFrampton ChrisDalbeth NicolaMerriman Tony RStamp Lisa K - N-lactoyl-phenylalanine (Lac-Phe) is a lactate-derived metabolite that suppresses food intake and body weight. Little is known about the mechanisms that mediate Lac-Phe transport across cell membranes. Here we identify SLC17A1 and SLC17A3, two kidney-restricted plasma membrane-localized solute carriers, as physiologic urine Lac-Phe transporters. In cell culture, SLC17A1/3 exhibit high Lac-Phe efflux activity. In humans, levels of Lac-Phe in urine exhibit a strong genetic association with the SLC17A1-4 locus. Urine Lac-Phe levels are increased following a Wingate sprint test. In mice, genetic ablation of either SLC17A1 or SLC17A3 reduces urine Lac-Phe levels. Despite these differences, both knockout strains have normal blood Lac-Phe and body weights, demonstrating SLC17A1/3-dependent de-coupling of urine and plasma Lac-Phe pools. Together, these data establish SLC17A1/3 family members as the physiologic urine Lac-Phe transporters and uncover a biochemical pathway for the renal excretion of this signaling metabolite. - Source: PubMed
Publication date: 2024/08/12
Li Veronica LXiao ShukeSchlosser PascalScherer NoraWiggenhorn Amanda LSpaas JanTung Alan Sheng-HwaKaroly Edward DKöttgen AnnaLong Jonathan Z - Phthalates, or dieters of phthalic acid, are a ubiquitous type of plasticizer used in a variety of common consumer and industrial products. They act as endocrine disruptors and are associated with increased risk for several diseases. Once in the body, phthalates are metabolized through partially known mechanisms, involving phase I and phase II enzymes. - Source: PubMed
Publication date: 2024/06/23
Bustamante MarionaBalagué-Dobón LauraBuko ZsanettSakhi Amrit KaurCasas MaribelMaitre LeaAndrusaityte SandraGrazuleviciene ReginaGützkow Kristine BBrantsæter Anne-LiseHeude BarbaraPhilippat ClaireChatzi LedaVafeiadi MarinaYang Tiffany CWright JohnHough AmyRuiz-Arenas CarlosNurtdinov Ramil NEscaramís GeòrgiaGonzález Juan RThomsen CathrineVrijheid Martine