Ask about this productRelated genes to: SIX1 antibody
- Gene:
- SIX1 NIH gene
- Name:
- SIX homeobox 1
- Previous symbol:
- DFNA23
- Synonyms:
- -
- Chromosome:
- 14q23.1
- Locus Type:
- gene with protein product
- Date approved:
- 1995-09-29
- Date modifiied:
- 2015-09-02
Related products to: SIX1 antibody
Related articles to: SIX1 antibody
- Craniofacial development requires precise coordination of epithelial patterning and morphogenesis. However, the molecular mechanisms governing olfactory epithelium development remain incompletely understood. Retinoic acid (RA) signaling and Gata3 have each been independently implicated in craniofacial morphogenesis, particularly in the formation of the primitive choanae, which constitute the opening between the nasal cavity and the oral cavity. Here, we generated a tamoxifen-inducible, genetically controlled compound mutant mouse model to simultaneously disrupt Rdh10, a rate-limiting enzyme for RA signaling, and Gata3 during early craniofacial development. We show that while deletion of Rdh10 following tamoxifen administration at E8.5 does not result in obvious craniofacial abnormalities, combined loss of Rdh10 and Gata3 leads to fully penetrant bilateral choanal atresia and severe defects in olfactory epithelium morphogenesis. Immunohistochemical analyses revealed a marked reduction in PAX6 and SIX1 positive cells and a concomitant expansion of SOX2 positive cells in compound mutant embryos. These results demonstrate that RA-Gata3 signaling cooperatively regulates olfactory epithelium development by controlling the balance between progenitor maintenance and lineage specification. We propose that the RA-Gata3 signaling pathway orchestrates a transcriptional network involving Pax6, Six1, and Sox2 to ensure proper epithelial patterning, branching morphogenesis, and choanae formation during early craniofacial development. - Source: PubMed
Matsushita AyakaTsujimoto TakayukiXiuping NieOmi-Sugihara MaikoXu LinMithun SahaNatsuyama ShotaOhara HarukaKoga SatoshiInubushi ToshihiroSandell Lisa LTrainor Paul AYamashiro TakashiKurosaka Hiroshi - The molecular and histologic characteristics associated with the development of post-traumatic capsular fibrosis of the shoulder joint following open reduction and internal fixation (ORIF) of proximal humerus fractures (PHF) remain incompletely understood. To help elucidate these mechanisms, this hypothesis-generating pilot study aimed to examine gene expression and histological changes in the joint capsule of patients undergoing implant removal and adhesiolysis for post-traumatic stiffness after surgical fixation of PHF. - Source: PubMed
Publication date: 2026/05/08
Henssler LeopoldDrenkard DanielaRiedl MoritzKlute LisaKeil FelixAlt VolkerRiool MartijnKerschbaum Maximilian - The Six1 (SIX homeobox 1) gene is pivotal in renal and pulmonary development and differentiation. Its dysregulation is implicated in oncogenesis and tumor progression via enhancing cell proliferation and delaying senescence. However, whether or how it functions in the natural aging have not been investigated. To answer this question, we generated Six1 gene knockout mice using CRISPR-Cas9 technology. All Six1 biallelic knockout mice died at birth since the underdeveloped lungs. In Six1 mice, the developmental deficiencies in kidneys with vacuolar degeneration and epithelial disruption in renal tubules, as well as hematopoietic interstitial infiltration and lungs with interstitial condensation and alveolar hypoplasia were observed. These developmental deficiencies persist with age and age-dependent phenotypes become more pronounced in Six1 mice compared to the wild-type, with upregulation of senescence markers (p16, p53) and senescence-associated secreted factors (e.g., TNF-α, TIMP-2), increased α-SMA expression and collagen deposition, as well as susceptibility to pulmonary fibrosis. Transcriptomic sequencing coupled with bioinformatics analysis indicated that genes with altered expression in Six1 mouse lungs showed enrichment in pathways associated with senescence, including the NF-κB and TNF signaling pathways. These transcriptional patterns were also associated with gene sets involved in mitochondrial metabolic processes. Collectively, these findings suggest that Six1 haploinsufficiency is associated with transcriptional signatures linked to aging-related pathways under physiological conditions in mice, providing potential clues for future studies exploring mechanisms of aging. - Source: PubMed
Publication date: 2026/05/06
Guo TianxuLiu HanMa JunjunYan HuanyuChen YanglinZhao LihuaGuo XiyunLv LiminWang YixiCheng LinxinYang GuangZhang YuYu JinboWang XiDuo ShuguangLi XiheLi Rongfeng - Congenital anomalies of the kidney and urinary tract (CAKUT) comprise a heterogeneous group of developmental disorders with diverse genetic etiologies. However, it remains unclear whether these genetic factors converge on shared cellular programs across development and tissues. - Source: PubMed
Publication date: 2026/04/27
Pflugfelder MaraEberts AntoniaKoch VeraMartynov IllyaMaj CarloSeitz GuidoSchumacher JohannesVahdad Mohammad RezaDasmeh Pouria - - Source: PubMed
Publication date: 2026/04/10