Ask about this productRelated genes to: SH3RF1 antibody
- Gene:
- SH3RF1 NIH gene
- Name:
- SH3 domain containing ring finger 1
- Previous symbol:
- SH3MD2
- Synonyms:
- POSH, RNF142, KIAA1494
- Chromosome:
- 4q32.3-q33
- Locus Type:
- gene with protein product
- Date approved:
- 2003-12-01
- Date modifiied:
- 2018-02-13
Related products to: SH3RF1 antibody
Related articles to: SH3RF1 antibody
- The Gentile di Puglia is a local Italian Merino-type sheep breed of high historical and economic value, known for its fine wool, and whose conservation depends on an accurate assessment of its genomic diversity. Using a medium-density Single-Nucleotide Polymorphism (SNP) array, we analysed the population structure, homozygosity and heterozygosity patterns of 1 337 individuals genotyped for 45 869 autosomal SNPs, representing one of the largest datasets available for a local sheep breed. Genetic diversity indices highlighted moderate-to-high heterozygosity and low genomic inbreeding. Population structure analysis revealed clear differentiation among farms shaped by historical breeding origins and recent management practices. Runs of homozygosity (ROH) analysis showed that most segments were short (< 4 Mb), indicating predominantly ancient inbreeding, likely reflecting historical demographic processes rather than recent consanguineous matings. Several recurrent ROH islands were identified on ovine chromosomes (OAR) 2, OAR6, OAR10, and OAR19, harbouring genes associated with growth, fat metabolism, reproduction, immunity, and environmental adaptation. Heterozygosity-rich regions (HRRs) consisted of short segments (< 1 Mb), with two HRR islands harbouring genes of potential functional relevance (VPS13B, CLCN3, NEK1, SH3RF1), which may contribute to reproductive traits, disease resistance, or overall fitness. Partial overlap between ROH and HRR islands was observed, suggesting a nuanced genetic structure in which patterns of homozygosity and heterozygosity may contribute differently to shaping genetic diversity. Overall, this integrated genomic approach provides a comprehensive assessment of the current genetic status of the Gentile di Puglia breed and a solid scientific foundation for the design and implementation of effective conservation strategies. In this context, genomic data serve as a critical resource for informed decision-making. - Source: PubMed
Publication date: 2026/04/30
Chessari GLandi VRiggio SSardina M TCiani ECriscione APersichilli CSenczuk GMastrangelo S - Papillary thyroid carcinoma (PTC) represents the most prevalent sort of thyroid malignancy, and its incidence has been consistently increasing worldwide. Although most PTC cases exhibit indolent behavior, a subset demonstrates aggressive characteristics, leading to recurrence, metastasis, and poor clinical outcomes. This study aims to unveil the molecular mechanism of PTC and identify potential biomarkers for its early diagnosis and individualized treatment. - Source: PubMed
Publication date: 2026/03/24
Zhai XinyuGu XueZhang ShengcanHuang HanzhaoYe Hui - Idiopathic pulmonary fibrosis (IPF) is a deadly lung disease and currently has limited treatment options. E3 ubiquitin ligases play a role in multiple diseases; however, there are few studies involving them in the development of IPF. This study aimed to develop an E3 ubiquitin ligase gene-based risk signature model to predict the prognosis of patients with IPF. - Source: PubMed
Liu JunhuiZhu LongfeiLi GuirongChen Jingyu - Cancer-related fatigue is a multifactorial condition that affects most people undergoing chemotherapy. To elucidate potential biological underpinnings of fatigue, this study tested correlations between patient-reported fatigue and (1) functional measures and (2) transcriptomics of whole blood. - Source: PubMed
Publication date: 2025/06/05
Kleckner Amber SMocci EvelinaClingan Carin LYoungblood Shari MRosenblatt Paula YTkaczuk Katherine H RKleckner Ian RDorsey Susan G - During mammalian spermatogenesis, the cytoskeleton system plays a significant role in morphological changes. Male infertility such as non-obstructive azoospermia (NOA) might be explained by studies of the cytoskeletal system during spermatogenesis. - Source: PubMed
Publication date: 2025/01/25
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